Testing at ARUP Laboratories  Testing at ARUP Laboratories

LipoFit by NMR

LipoFit by NMR is a competitive alternative to lipid particle analysis tests. High-resolution nuclear magnetic resonance (NMR) technology is used to measure a patient’s lipoprotein particle number and size.

When to order testing?

Lipid particle analysis testing may be useful to guide therapy in appropriate high- risk patients:

  • Type 2 diabetes mellitus
  • Metabolic syndrome
  • Elevated triglycerides

It is not recommended to routinely order lipid particle analysis as screening tests for cardiovascular disease.

Benefits of Lipid Particle Analysis Testing at ARUP?

  • Testing performed seven days per week
  • Enhanced graphical reports available for both tests
  • Extended refrigerated specimen stability (stable 30 days) for ARUP test code 2013715

Three Easy Steps for Quality Results

  1. Patient fasting is required.
    • 12-hour fasting recommended
      Why?
      Elevated triglycerides can interfere with accurate measurements of lipoprotein particle size and number by NMR.
  2. Use the appropriate collection tube.
    • Greiner Bio-One Clot Activator Tubes (ARUP supply #54325) or plain red top serum tubes (BD or Greiner) are acceptable.
    • BD serum separator tubes are not acceptable.
      Why?
      Use of incompatible tubes can lead to quantitative interferences and/or inability to report results.
    • Tube type compatibility for LipoFit is similar to alternative NMR-based assays.
  3. Transfer 4 mL serum to an ARUP Standard Transport Tube (minimum 2 mL required).

Ordering Information & Specimen Requirements

  • Please contact your hospital or reference laboratory to inquire about pricing, test-request forms, and billing for this test.
  • Patient preparation – Patient required to fast prior to specimen collection.
  • Specimen collection – Greiner Bio-One Clot Activator Tube with NMR labeled transport tube (ARUP supply #54325) available online through eSupply using ARUP Connect™ or by contacting ARUP Client Services at 800-522-2787. Also acceptable: Plain Red. For clients using their own specimen transport tubes, "ARUP NMR Serum" labels (ARUP supply #55652) are available.
  • Transport temperature – Refrigerated.

Featured Article

Tube Interference with NMR lipoprotein analysis

Additional Resources

Nontraditional Cholesterol Test: Faster Results In-house

ARUP Consult

Atherosclerotic Cardiovascular Disease  Risk Markers 

References

1. DC Heart Disease Facts www.cdc.gov/heartdisease/facts.htm (accessed on July 7, 2017).

2. Atherosclerotic Cardiovascular Disease (ASCVD) Traditional Risk Markers—Cardiovascular Disease Risk Markers (Traditional) www.arupconsult.com (accessed on August 8, 2017).

3. Low-density lipoprotein particle number and risk for cardiovascular disease. www.ncbi.nlm.nih.gov/pubmed/15296705 (accessed on July 7, 2017).