Be confident in your diagnostic decisions about
prostate cancer.

Is biopsy the next step? Find out with Prostate Health Index from ARUP Laboratories.

Prostate Health Index (phi) is a simple, FDA-approved blood test that helps determine the probability of detecting prostate cancer with a biopsy. This test uses an algorithm to assess total PSA, free PSA, and p2PSA, and is recommended by the National Comprehensive Cancer Network (NCCN) guidelines for early cancer detection prior to biopsy.

Evidence suggests phi is more efficient at prostate cancer detection than testing for total and free PSA alone. The test may be useful as part of a multivariable approach to reduce prostate biopsies and over-diagnosis.1 In fact, a recent multi-center study of 506 men who received phi testing and 683 men who were not tested with phi showed a significant reduction in biopsy procedures performed (36.4% vs. 60.3% respectively).2


 

 
 
 

ORDERING RECOMMENDATION

 
  • Men aged 50 or older
  • Total PSA between 4 and 10 ng/mL
  • DRE not suspicious for cancer
    (specimens for testing should be drawn prior to DRE or other prostate manipulations)
 
  • Men aged 40-80
  • No DRE in previous 4 days
  • No previous prostate cancer diagnosis
  • No treatment of BPH, invasive urologic procedure with secondary PSA eval, or 5-ARI therapy in past 6 months
 

SPECIMEN TYPE

 

1.5 mL serum (critical frozen)

 

4 mL serum (refrigerated or frozen)


 

TESTING LOCATION

 

In-house at ARUP, under standardized conditions in a CLIA- and CAP-certified lab

 

Sendout


TURNAROUND TIME

 

Results within 24 hours of scheduled run

 

3–6 days


FDA APPROVAL

 

YES

 

NO


For pricing information, please contact your ARUP Account Executive.
For more information about prostate cancer screening, visit ARUP Consult Prostate Cancer.


References

1. Loeb S, et al. The prostate health index selectively identifies clinically significant prostate cancer. ncbi.nlm.nih.gov/pubmed/25463993 (accessed April 2019)

2. White J, et al. Clinical utility of the Prostate Health Index (phi) for biopsy decision management in a large group urology practice setting. ncbi.nlm.nih.gov/pubmed/29158509 (accessed March 2019).