ARUP Minimal Residual Disease (MRD) Test Offerings

Minimal (or measurable) residual disease (MRD) findings have been shown in numerous studies to correlate strongly with clinical outcomes in the posttherapy setting. In addition, MRD results provide early insights into the depth of response to therapy and actionable data for providers to use in deciding whether to end or escalate therapy. ARUP’s MRD test offerings are based on the specific clinical indication and thus offer excellent sensitivity.

Benefits of Testing at ARUP

In addition to the MRD test offerings, ARUP offers a broad menu of oncology testing to aid in the diagnosis and treatment of your patients. We also provide consistent reporting with expert consultations from top industry medical directors and scientists.


ARUP uses a variety of testing methods, including flow cytometry for MRD testing, which offers faster turnaround time and lower cost compared with MRD testing via next generation sequencing (NGS). Also, MRD testing using flow cytometry does not require sequencing of the original tumor. Additional tests for specific subtypes of acute myeloid leukemia (AML) and B-cell acute lymphocytic leukemia (B-ALL) using reverse-transcriptase polymerase chain reaction (RT-PCR) are also available.

Available Testing

Clinical Indication Test Name Test Code Limits ARUP Consult Topic
PML-RARA Detection by RT-PCR, Quantitative 2002871 LOQ: 0.01% Acute Myeloid Leukemia - AML
NPM1 Mutation Detection by RT-PCR, Quantitative 3000066 LOQ: 0.001%
RUNX1-RUNX1T1 (AML1-ETO) t(8;21) Detection, Quantitative 2010138 LOQ: 0.001%
CBFB-MYH11 inv(16) Detection, Quantitative 2011114 LOQ: 0.001%
Quantitative Detection of BCR-ABL1, Major Form (p210) 3005840 LOQ: %IS=0.0032
B-Cell Acute Lymphocytic Leukemia (B-ALL) Minimum Residual Disease Detection by Flow Cytometry (COG Protocol) 3000724 LOD/LOQ: 0.01% Acute Lymphoblastic Leukemia - ALL
BCR-ABL1, Minor (p190), Quantitative 2005016 LOQ: 0.0008%
CML Quantitative Detection of BCR-ABL1, Major Form (p210) 3005840 N/A Chronic Myelogenous Leukemia - CML
CLL/SLL Chronic Lymphocytic Leukemia Minimum Residual Disease by Flow Cytometry 3003142 LOD: 0.0039% LOQ: 0.01% Chronic Lymphocytic Leukemia - CLL
Multiple Myeloma Multiple Myeloma Minimum Residual Disease by Flow Cytometry 3002069 LOD/LOQ: 0.001% Plasma Cell Dyscrasias
B-LBL, B-cell lymphoblastic leukemia/lymphoma; LOD, limit of detection; LOQ, limit of quantification