Timely detection of in utero drug exposure is critical for effective detection and management of intoxication, withdrawal syndrome, and long-term needs (social and medical) for exposed neonates. Two modes of testing are available: umbilical cord tissue and meconium.

Chain-of-custody may not be required:

Umbilical cord and meconium drug tests are performed to support clinical and social management decisions, and do not usually require chain-of-custody.

If chain-of-custody is required, ARUP can provide a specimen tracking form to help authenticate the specimen collection and transport process, if desired. Contact ARUP Client Services for more information.

Meconium

Meconium is the traditional specimen to detect and document maternal drug use during pregnancy, approximately the last trimester of a full-term birth. ARUP’s neonatal drug testing in meconium is a qualitative immunoassay screen for nine drug classes. Specimens testing positive for one or more drugs are reflexed to highly sensitive and specific mass spectrometry technology for confirmation.

Drugs and Drug Metabolites Reported

Opioids Stimulants Sedatives/Hypnotics Other

buprenorphine
norbuprenorphine
methadone
methadone metabolite (EDDP)
heroin metabolite
(6-acetylmorphine)
morphine
codeine
hydromorphone
hydrocodone
oxycodone
oxymorphone

methamphetamine
amphetamine
MDA
MDEA (Eve)
MDMA (Ecstasy)
cocaine
cocaine metabolites:
benzoylecgonine
m-hydroxybenzoylecgonine
cocaethylene

alprazolam
a-hydroxyalprazolam
butalbital
clonazepam
7-amino clonazepam
diazepam
nordiazepam
oxazepam
temazepam
lorazepam
midazolam
phenobarbital

cannabis (THC) metabolite
phencyclidine (PCP)

Umbilical Cord Tissue

Umbilical cord tissue is a relatively new specimen to detect and document maternal drug use during pregnancy, approximately the last trimester of a full term birth. ARUP’s neonatal drug testing in umbilical cord tissue is based on highly sensitive and specific qualitative liquid chromatography and tandem mass spectrometry (LC-MS/MS) .

For additional information regarding testing strategies, refer to our Laboratory Test Directory.

Drugs and Drug Metabolites Reported in Drug Detection Panel, Umbilical Cord Tissue, Qualitative (2006621)

Opioids Stimulants Sedatives/Hypnotics Other

​buprenorphine
norbuprenorphine
methadone
methadone metabolite (EDDP)
heroin metabolite
(6-acetylmorphine)
morphine
codeine
dihydrocodeine
hydrocodone
norhydrocodone
hydromorphone
oxycodone
noroxycodone
oxymorphone
noroxymorphone
tramadol
n-desmethyl tramadol
o-desmethyl-tramadol
tapentadol
meperidine
fentanyl
propoxyphene
naloxone​

methamphetamine
amphetamine
MDMA (Ecstasy)
cocaine
cocaine metabolites:
benzoylecgonine
m-hydroxybenzoylecgonine
cocaethylene
phentermine

7-amino clonazepam
a-hydroxyalprazolam
a-hydroxymidazolam
alprazolam
butalbital
clonazepam
diazepam
lorazepam
midazolam
nordiazepam
oxazepam
phenobarbital
temazepam
zolpidem

phencyclidine (PCP)
gabapentin

 

Additional Resources