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Allie H. Grossmann, MD, PhD
Pathologist
Subspecialties: Sarcoma pathology and solid tumor molecular pathology
Associate Professor, University of Utah School of Medicine
Specialties
Molecular Oncologic Pathology
Sarcoma
Education
Doctorate Degree—Oregon Health Sciences University
Medical Degree—Oregon Health Sciences University
Residency—Anatomic Pathology, University of Utah School of Medicine
Fellowship—Molecular Medicine, University of Utah School of Medicine
Fellowship—Molecular Genetic Pathology, University Of Utah School of Medicine
Certification/Affiliations
American Board of Pathology (Molecular Genetic Pathology, Anatomic)
Research Interests
Mechanisms of tumorigenesis, metastasis, and the development of targeted and immunotherapies for cancer treatment
Awards
Harry J. Lloyd Charitable Trust Career Development Award (2015–17)
NCI K08 Mentored Clinical Scientist Award (2015–20)
American Cancer Society Research Scholars Grant (2019–23)
Recent Publications
Yoo JH, et al. The small GTPase ARF6 activates PI3K in melanoma to induce a prometastaticstate . Cancer Res . 2019 Jun 1;79(11):2892–908.
Kircher DA, et al. AKT1E17K activates focal adhesion kinase andpromotes melanoma brain metastasis . Mol Cancer Res . 2019 Sep;17(9):1787–1800.
Ekiz HA, et al. MicroRNA-155 coordinates the immunological landscape within murinemelanoma and correlates with immunity in human cancers . JCI Insight . 2019 Mar 21;4(6).
Barrott JJ, et al. Paracrine osteoprotegerin and β-catenin stabilization support synovialsarcomagenesis in periosteal cells . J Clin Invest . 2018 Jan 2;28(1):207–18.
Yang H, et al. Activated MEK cooperates with Cdkn2a and Pten loss to promote the developmentand maintenance of melanoma . Oncogene . 2017 Jul 6;36(27):3842–51.
Yoo JH, et al. ARF6 is an actionablenode that orchestrates oncogenic GNAQ signaling in uveal melanoma . Cancer Cell . 2016 Jun 13;29(6):889–904.
Cho JH, et al. AKT1 activation promotesdevelopment of melanoma metastases . Cell Rep . 2015 Nov 3;13(5):898–905.
Barrott JJ, et al. β-catenin stabilization enhancesSS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition . Oncotarget . 2015 Sep 8;6(26):22758–66.
Sant DW, et al. Evaluation of somatic mutations intibial pseudarthrosis samples in neurofibromatosis type 1 . J Med Genet. 2015 Apr;52(4):256–61.
Shin CH,et al. The BRAF kinase domain promotes the development of gliomas in vivo . Genes Cancer . 2015 Jan;6(1–2):9–18.
Gibson CC, et al. Strategy for identifying repurposed drugs for thetreatment of cerebral cavernous malformation . Circulation . 2015 Jan 20;131(3):289–99.
Chaturvedi A, et al. Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma .Mol Biol Cell . 2014 Sep 15;25(18):2695–709.
Abel HJ, et al. Detection of gene rearrangements in targeted clinical next-generation sequencing .J Mol Diagn . 2014 Jul;16(4):405–17.
Goodwin ML, et al. Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment . Cancer Cell . 2014 Dec 8;26(6):851–62.