ARUP's Laboratory Test Directory

Streptococcus pneumoniae Antibodies, IgG (23 Serotypes) : 2005779

Mnemonic: PNEUMO 23

Methodology: Quantitative Multiplex Bead Assay
Performed: Tue
Reported: 1-4 days
Specimen Required: Collect: Serum separator tube. Post-immunization specimen should be drawn 30 days after immunization and, if shipped separately, must be received within 60 days of pre-immunization specimen.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL) MARK SPECIMENS CLEARLY AS "PRE" OR "POST" SO SPECIMENS WILL BE SAVED AND TESTED SIMULTANEOUSLY.

Storage/Transport Temperature: Refrigerated. "Pre" and "post" pneumococcal vaccine specimens can be submitted separately or together for testing.

Unacceptable Conditions: Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles).
Interpretive Data: A post-immunization antibody concentration of 1.30 µg/mL or greater indicates adequate immune response. When comparing to pre-immunization concentrations that are 1.30 µg/mL or greater, a fourfold or greater increase in post-immunization concentration indicates adequate response; however, a high pre-immunization antibody concentration may preclude a fourfold increase.

Indication of immune system competence is demonstrated by an adequate immune response to at least 50 percent of the serotypes included in the vaccine challenge.

See Compliance Statement B: www.aruplab.com/CS
Note: Includes Serotypes 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F. (Conjugated Serotypes: 1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F.).

This assay is designed to use both pre- and post-immunization specimens to assess immune responsiveness to pneumococcal vaccine. This test is not designed to determine protection to Streptococcus pneumoniae based on a single specimen.
CPT Code(s): 86317 x23