| Ordering Recommendation: |
Order in cases of Philadelphia chromosome positive (Ph+) lymphoblastic leukemia to quantify the BCR-ABL1 p190 fusion form. For CML, use BCR-ABL1, Major (p210), Quantitative, (2005017).
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| Methodology: |
Quantitative Reverse Transcription Polymerase Chain Reaction
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| Performed: |
RNA isolation: Sun-Sat
Assay: Varies
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| Reported: |
5-7 days
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| Specimen Required: |
Collect: Lavender (EDTA) or bone marrow (EDTA).
Specimen Preparation: Transport 5 mL whole blood or 3 mL bone marrow. (Min: 1 mL whole blood or 1 mL bone marrow) Specimens must be received within 48 hours of collection due to lability of RNA.
Storage/Transport Temperature: Refrigerated.
Unacceptable Conditions: Serum or plasma. Specimens collected in anticoagulants other than EDTA. Severely hemolyzed specimens. Frozen or clotted specimens.
Stability (collection to initiation of testing): Ambient: 1 hour; Refrigerated: 48 hours; Frozen: Unacceptable
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