ARUP's Laboratory Test Directory

BCR-ABL1, Qualitative with Reflex to BCR-ABL1 Quantitative : 2005010
[ image for: Time Sensitive]
Time Sensitive
  


Mnemonic: BCR RFLX

Ordering Recommendation: For use in detecting the presence of a BCR-ABL1 fusion, for determining breakpoint status, and for baseline quantitation.
Methodology: Reverse Transcription Polymerase Chain Reaction
Performed: RNA isolation: Sun-Sat
Assay: Varies
Reported: 7-10 days
Specimen Required: Collect: Lavender (EDTA) or bone marrow (EDTA).

Specimen Preparation: Transport 5 mL whole blood or 3 mL bone marrow. (Min: 1 mL whole blood or 1 mL bone marrow) Specimens must be received within 48 hours of collection due to lability of RNA.

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Serum or plasma. Specimens collected in anticoagulants other than EDTA. Severely hemolyzed specimens. Frozen or clotted specimens.

Stability (collection to initiation of testing): Ambient: 1 hour; Refrigerated: 48 hours; Frozen: Unacceptable
Interpretive Data: Refer to report.

See Compliance Statement B: www.aruplab.com/CS
Note: This reflex assay is recommended when the BCR-ABL1 fusion form is not known or unclear.  This reflex assay detects the presence of either the p210 (major breakpoint) or p190 (minor breakpoint).  If the presence of either the p210 or p190 BCR-ABL1 fusion is detected, then the appropriate quantitative test will be performed.

If the fusion form is known, refer to BCR-ABL1, Major (p210), Quantitative  (ARUP test code 2005017) or BCR-ABL1, Minor (p190), Quantitative (ARUP test code 2005016).
CPT Code(s): 81206, 81207, G0452;
If reflexed, add 81206 or 81207