ARUP's Laboratory Test Directory

Cytomegalovirus Antiviral Drug Resistance by Sequencing : 2004760

Mnemonic: CMV RESIST

Methodology: Polymerase Chain Reaction/Sequencing
Performed: Sun-Sat
Reported: 2-3 days
Specimen Required: Collect: Lavender (EDTA), pink (K2EDTA) or plasma preparation tube.

Specimen Preparation: Separate plasma from cells within 8 hours. Transfer 4 mL plasma to an ARUP Standard Transport Tube. (Min: 2.5 mL)

Storage/Transport Temperature: Frozen.

Remarks: Please submit most recent viral load and test date, if available.

Unacceptable Conditions: Serum. Heparinized specimens.

Stability (collection to initiation of testing): Ambient: 8 hours; Refrigerated: 72 hours; Frozen: 1 month
Interpretive Data: Codons 457-630 of the UL97 gene and codons 393-1000 of the UL54 gene are sequenced. Mutations associated with resistance to ganciclovir, cidofovir, and foscarnet are reported. Mutations in viral sub-populations below 20 percent of total may not be detected.

See Compliance Statement B: www.aruplab.com/CS
Note: This test may be unsuccessful if the plasma CMV DNA viral load is less than 1,500 CMV DNA copies per mL of plasma.
CPT Code(s): 87910
Cross References: CMV (Cytomegalovirus Antiviral Drug Resistance by Sequencing), CMV Genotype (Cytomegalovirus Antiviral Drug Resistance by Sequencing), CMV Resistance (Cytomegalovirus Antiviral Drug Resistance by Sequencing), Cytomegalovirus Resistance (Cytomegalovirus Antiviral Drug Resistance by Sequencing)