ARUP's Laboratory Test Directory

Porphyrins, Fractionation and Quantitation, Urine : 2002058

Mnemonic: PORURINE

Methodology: Quantitative High Performance Liquid Chromatography
Performed: Sun-Fri
Reported: 1-4 days
Specimen Required: Collect: 24-hour or random urine. Refrigerate 24-hour specimens during collection.

Specimen Preparation: Protect from light. Transfer 4 mL aliquot of urine to an ARUP Amber Transport Tube. (Min: 2 mL) Record total volume and collection time interval on transport tube and test request form.

Storage/Transport Temperature: Frozen.

Unacceptable Conditions: Body fluids other than urine.

Stability (collection to initiation of testing): Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month
Reference Interval:
 
Test Number Components Reference Interval
 Uroporphyrin 0-4 µmol/mol crt
 Heptacarboxylate Porphyrin 0-2 µmol/mol crt
 Coproporphyrin I 0-6 µmol/mol crt
 Coproporphyrin III 0-14 µmol/mol crt
0020473Creatinine, 24-Hour Urine  
 
Age Male Female
3-8 years 140-700 mg/d 140-700 mg/d
9-12 years 300-1300 mg/d 300-1300 mg/d
13-17 years 500-2300 mg/d 400-1600 mg/d
18-50 years 1000-2500 mg/d 700-1600 mg/d
51-80 years 800-2100 mg/d 500-1400 mg/d
81 years and older 600-2000 mg/d 400-1300 mg/d

Interpretive Data: Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine).
Note: Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias such as acute intermittent porphyria (AIP) requires urine porphobilinogen (PBG) testing. Refer to Porphobilinogen (PBG), Urine (ARUP test code 0080260). 
CPT Code(s): 84120
Cross References: Porphyria Cutanea Tarda (PCT) (Porphyrins Profile, Plasma), Porphyrins, Fractionated, Quantitative, 24-Hour (Porphyrins, Fractionation & Quantitation, Urine)