ARUP's Laboratory Test Directory

Cardiolipin Antibodies, IgG & IgM : 0099344

Mnemonic: ANTI-CARD

Methodology: Enzyme-Linked Immunosorbent Assay
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect:  One 4 mL serum separator tube.

Transport:  1 mL serum at 2-8°C. (Min: 0.5 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport:  0.15 mL serum at 2-8°C.

Remarks:  Separate serum from cells ASAP.

Unacceptable Conditions:  Plasma and other body fluids.  Heat-inactivated, hemolyzed, lipemic, or contaminated specimens.

Stability:  After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
 
Test Number Components Reference Interval
0050901Cardiolipin Antibody, IgG < 15 GPL: Absent or none detected
15-19 GPL: Inconclusive
20-79 GPL: Moderate positive
³ 80 GPL: High positive 
0050902Cardiolipin Antibody, IgM < 12 MPL: Absent or none detected
12-19 MPL: Inconclusive
20-79 MPL: Moderate positive
³ 80 MPL: High positive

Interpretive Data: Results in the inconclusive range and positive results for IgM only should be carefully interpreted.  Most patients with "antiphospholipid antibody syndrome" (Br J Rheumatol 26:324-326, 1987) have moderate or high levels of cardiolipin antibodies and are positive for IgG only, or IgG and IgM. 
Note: GPL = IgG phospholipid units; MPL = IgM phospholipid units
CPT Code(s): 86147 x2
 
 

 

 

 
All ARUP Sites:        www.aruplab.com     ·     www.arupconsult.com     ·     www.arup.utah.edu     ·     www.childx.org     ·     www.utahblood.org