ARUP's Laboratory Test Directory

Felbamate : 0094030

Mnemonic: FELBAMA

Methodology: Quantitative High Performance Liquid Chromatography
Performed: Mon, Wed, Fri
Reported: 1-4 days
Specimen Required: Patient Prep: Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect: Plain red. Also acceptable: Lavender (EDTA), pink (K2EDTA), green (sodium heparin), gray (sodium fluoride/potassium oxalate). Avoid use of separator tubes and gels.

Specimen Preparation: Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 1 month; Frozen: 6 months

Reference Interval:
Effective February 19, 2013
 
Therapeutic Range Not well established.
Toxic Level Greater than 200 µg/mL

Interpretive Data: The proposed therapeutic range for seizure control is 30-60 µg/mL. Pharmacokinetics vary widely, particularly with co-medications, age and/or compromised renal function. Felbamate use is associated with an increased incidence of liver failure and aplastic anemia.
CPT Code(s): 80299
Cross References: Felbatol (Felbamate)