ARUP's Laboratory Test Directory

Nicotine and Metabolites, Urine : 0092356

Mnemonic: NICOTINEUR

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed: Sun-Sat
Reported: 1-4 days
Specimen Required: Collect: Random urine.

Specimen Preparation: Transfer 4 mL with no additives or preservatives urine to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature: Room temperature.

Unacceptable Conditions: Specimens exposed to repeated freeze/thaw cycles.

Stability (collection to initiation of testing): Ambient: 10 days; Refrigerated: 10 days; Frozen: 8 months
Reference Interval:
Unexposed non-tobacco user Passive exposure Abstinent user for greater than 2 weeks Active tobacco product use
Nicotine Less than 2 ng/mL Less than 20 ng/mL Less than 30 ng/mL 1000-5000 ng/mL
Cotinine Less than 5 ng/mL Less than 20 ng/mL Less than 50 ng/mL 1000-8000 ng/mL
3-OH-Cotinine Less than 50 ng/mL Less than 50 ng/mL Less than 120 ng/mL 3000-25000 ng/mL
Nornicotine Less than 2 ng/mL Less than 2 ng/mL Less than 2 ng/mL 30-900 ng/mL
Anabasine Less than 3 ng/mL Less than 3 ng/mL Less than 3 ng/mL 3-500 ng/mL*
Adapted from Clinical Chemistry 2002;48:1460-71.

Interpretive Data: The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

For medical purposes only; not valid for forensic use.

See Compliance Statement B: www.aruplab.com/CS
CPT Code(s): 83887
Cross References: 3-Hydroxycotinine (Nicotine & Metabolites, Urine), Anabasine (Nicotine & Metabolites, Urine), Cotinine (Nicotine & Metabolites, Urine), Nicotine and Cotinine, LC/MS/MS, Urine (Nicotine & Metabolites, Urine), Nornicotine (Nicotine & Metabolites, Urine), Pain Management (Nicotine & Metabolites, Urine)