Reference Interval:
Therapeutic Range:
Kidney and Liver:
0-2 months post-transplant: 10.0-15.0 ng/mL
3 months and older: 5.0-10.0 ng/mL
Heart:
0-2 months post-transplant: 10.0-18.0 ng/mL
3 months and older: 8.0-15.0 ng/mL
Toxic: 26 ng/mL or greater
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| Interpretive Data: |
Therapeutic range is based on a whole blood specimen drawn 12 hours post-dose or prior to next dose (the trough) using the Microparticle Enzyme Immunoassay (MEIA) method. Some other factors influencing therapeutic range, dose administered, and result interpretation include time since transplantation, the organ transplanted, co-administration of other immunosuppressants, interaction with other drugs which may increase or decrease the tacrolimus concentration, and the preferences of the transplant centers and clinicians.
Beginning November 26, 2007, ARUP will transition the testing method for Tacrolimus (Tacro) from an immunoassay method to an HPLC-MS/MS method. Both results will be reported for all specimens until January 1, 2008. Currently the immunoassay result will be reported in the result field and the HPLC-MS/MS result will be reported as a comment to the report. The therapeutic range is based on analytical technique and must be considered relative to clinical factors such as time post trasplant, co-medications, co-morbitities, etc. Results by HPLC-MS/MS are generally lower than those generated by immunoassay.
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| CPT Code(s): |
80197
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