ARUP's Laboratory Test Directory

Amiodarone and Metabolite : 0090161

Mnemonic: AMIOD

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed: Sun-Sat
Reported: 1-4 days
Specimen Required: Patient Prep: Timing of specimen collection: Pre-dose (trough) draw - at steady state concentration.

Collect: Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation: Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Amber Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Stability (collection to initiation of testing): After separation from cells: Ambient: 1 month; Refrigerated: 6 weeks; Frozen: 6 weeks
Reference Interval:
Effective February 19, 2013
 
Therapeutic Range Total (amiodarone and metabolite):  0.5-2.0 µg/mL
Toxic Level Greater than 3.0 µg/mL

Interpretive Data: Toxic concentrations may exacerbate arrhythmias, cause liver and lung toxicity, and thyroid dysfunction. The concentration of desmethylamiodarone, an active major metabolite, is also reported, but no therapeutic range is established. At steady-state, the metabolite concentration is similar to the amiodarone concentration.
CPT Code(s): 80299
Cross References: Cordarone (Amiodarone and Metabolite), Nexterone (Amiodarone and Metabolite), Pacerone (Amiodarone and Metabolite)