#ExistRefRangeSet>
Reference Interval:
#ExistRefRangeTable> | Reference Intervals for 24-Hour Calculations (24-Hour Urine)
| | | Test Number
| Components
| Reference Interval
| | | Dopamine | | Effective February 21, 2012
| | Age
| Dopamine
| | 0-17 years
| Not Established
| | 18 years and older
| 60-440 µg/d
|
| | | Epinephrine | | Effective February 21, 2012
| | Age
| Epinephrine
| | 0-17 years
| Not Established
| | 18 years and older
| 0-25 µg/d
|
| | | Norepinephrine
| | Effective February 21, 2012
| | Age
| Norepinephrine
| | 0-17 years
| Not Established
| | 18 years and older
| 0-100 µg/d
|
| | 0020473 | Creatinine, 24-Hour Urine
| | Age
| Male
| Female
| | 3-8 years
| 140-700 mg/d
| 140-700 mg/d
| | 9-12 years
| 300-1300 mg/d
| 300-1300 mg/d
| | 13-17 years
| 500-2300 mg/d
| 400-1600 mg/d
| | 18-50 years
| 1000-2500 mg/d
| 700-1600 mg/d
| | 51-80 years
| 800-2100 mg/d
| 500-1400 mg/d
| | 81 years and older
| 600-2000 mg/d
| 400-1300 mg/d
|
|
| Reference Intervals for Ratio-to-Creatinine (CRT) Calculations (Random Urine)
| |
|
| | Available Separately
| Components
| Reference Interval
| | | | | Age
| Dopamine
| | No
| Dopamine
| 0-11 months 1-3 years 4-10 years 11-17 years 18 years and older
| 240-1290 µg/g crt 80-1220 µg/g crt 220-720 µg/g crt 120-450 µg/g crt 0-250 µg/g crt
| | | | Age
| Epinephrine
| | No
| Epinephrine
| 0-11 months 1-3 years 4-10 years 11-17 years 18 years and older
| 0-380 µg/g crt 0-82 µ/g crt 5-93 µg/g crt 3-58 µg/g crt 0-20 µg/g crt
| | | | Age
| Norepinephrine
| | No
| Norepinephrine
| 0-11 months 1-3 years 4 -10 years 11-17 years 18 years and older
| 25-310 µg/g crt 25-290 µg/g crt 27-110 µg/g crt 4-105 µg/g crt 0-45 µg/g crt
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*ExistRefRangeTable>
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*ExistRefRangeSet>
#ExistInterpDataSet>
| Interpretive Data: |
#ExistInterpData>The optimal specimen for this testing is a 24-hour urine collection. Mass per day calculations are not reported for patients younger than 18 years of age and for the following specimen types: a random collection, a collection with duration of less than 20 hours, a collection with duration of greater than 28 hours, or a collection with total volume less than 400 mL. Ratios to creatinine may be useful for these evaluations.
Smaller increases in catecholamine concentrations (less than two times the upper limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Significant elevation of one or more catecholamines (three or more times the upper reference limit) is associated with an increased probability of a neuroendocrine tumor.
*ExistInterpData>
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*ExistInterpDataSet>
#ExistNote>
| Note: |
Secreting neuroendocrine tumors are typically associated with catecholamine concentrations several times higher than the upper reference intervals. Large elevations can be seen in life-threatening illnesses and drug interferences. Common reasons for slight and moderate elevations include intense physical activity, emotional and physical stress, drug interferences, and improper specimen collection.
Medications which may physiologically interfere with catecholamines and metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levodopa (Sinemet®), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), ethanol, isoproterenol, methyldopa (Aldomet®), MAO inhibitors, nicotine, nose drops, propafenone (Rythmol), reserpine, theophylline, tricyclic antidepressants, and vasodilators. The effects of some drugs on catecholamine results may not be predictable.
References: 1). Optimal collection and storage conditions for catecholamine measurements in human plasma and urine. (Clinical Chemistry 1993; 39:2503-8.); 2). Effect of urine pH, storage time, and temperature on stability of catecholamines, cortisol, and creatinine. (Clinical Chemistry 1998; 44: 1759-62).
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*ExistNote>
#ExistCPT>
| CPT Code(s): |
82384
|
*ExistCPT>
#ExistCrossReferences>
Cross References: |
Adrenaline (Catecholamines Fractionated by LC-MS/MS, Urine Free), Dopamine, Random (Catecholamines Fractionated by LC-MS/MS, Urine Free), Epinephrine, Random (Catecholamines Fractionated by LC-MS/MS, Urine Free), Fractionation, Catecholamines (Catecholamines Fractionated by LC-MS/MS, Urine Free), Free Catecholamine Fractionation (Catecholamines Fractionated by LC-MS/MS, Urine Free), Noradrenaline (Catecholamines Fractionated by LC-MS/MS, Urine Free), Norepinephrine, Random (Catecholamines Fractionated by LC-MS/MS, Urine Free) |
*ExistCrossReferences>
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