Reference Interval:
| Components
| Reference Interval
| | Dopamine
| 60-440 µg/d
| | Epinephrine
| 0-25 µg/d
| | Norepinephrine
| 0-100 µg/d
|
| The urine catecholamines-to-creatinine ratios will be reported when the patient is under 18 years, or the urine collection is random, or other than 24 hours, or the urine volume is less than 400 mL/24 hours.
| | Test Number
| Components
| Reference Interval
| | | Dopamine | | Age
| Dopamine
| 0-11 months
1-3 years
4-10 years
11-17 years
18 years and older
| 240-1290 µg/g crt
80-1220 µg/g crt
220-720 µg/g crt
120-450 µg/g crt
0-250 µg/g crt
|
| | | Epinephrine | | Age
| Epinephrine
| 0-11 months
1-3 years
4-10 years
11-17 years
18 years and older
| 0-380 µg/g crt
0-82 µ/g crt
5-93 µg/g crt
3-58 µg/g crt
0-20 µg/g crt
|
| | | Norepinephrine
| | Age
| Norepinephrine
| 0-11 months
1-3 years
4 -10 years
11-17 years
18 years and older
| 25-310 µg/g crt
25-290 µg/g crt
27-110 µg/g crt
4-105 µg/g crt
0-45 µg/g crt
|
| | 0020473 | Creatinine, 24-Hour Urine
| | Male
| Female
| 3-8 years: 140-700 mg/d
9-12 years: 300-1300 mg/d
13-17 years: 500-2300 mg/d
18-50 years: 1000-2500 mg/d
51-80 years: 800-2100 mg/d
81 years and older: 600-2000 mg/d
| 3-8 years: 140-700 mg/d
9-12 years: 300-1300 mg/d
13-17 years: 400-1600 mg/d
18-50 years: 700-1600 mg/d
51-80 years: 500-1400 mg/d
81 years and older: 400-1300 mg/d
|
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| Interpretive Data: |
Ratios to creatinine may be useful for evaluation of patients younger than 18 years of age, when the urine collection is random or other than 24 hours, or the urine volume is less than 400 mL/24 hours.
Mass per day (mg or µg) calculations are not reported when the urine collection is random or other than 24 hours, or the urine volume is less than 400 mL/24 hours.
Smaller increases in catecholamine concentrations (less than two times the upper limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Significant elevation of one or both catecholamines (3 or more times the upper reference limit) is associated with an increased probability of a neuroendocrine tumor.
|
| Note: |
Secreting neuroendocrine tumors are typically associated with catecholamine concentrations several times higher than the upper reference intervals. Large elevations can be seen in life-threatening illnesses and drug interferences. Common reasons for slight and moderate elevations include intense physical activity, emotional and physical stress, drug interferences, and improper specimen collection.
Medications which may physiologically interfere with catecholamines and metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levodopa (Sinemet®), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), ethanol, isoproterenol, methyldopa (Aldomet®), MAO inhibitors, nicotine, nose drops, propafenone (Rythmol), reserpine, theophylline, tricyclic antidepressants, and vasodilators. The effects of some drugs on catecholamine results may not be predictable.
References: 1). Optimal collection and storage conditions for catecholamine measurements in human plasma and urine. (Clinical Chemistry 1993; 39:2503-8.); 2). Effect of urine pH, storage time, and temperature on stability of catecholamines, cortisol, and creatinine. (Clinical Chemistry 1998; 44: 1759-62).
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| CPT Code(s): |
82384
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