ARUP's Laboratory Test Directory

Renin Activity : 0070105

Mnemonic: RENIN

Methodology: Radioimmunoassay
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Patient Prep:  Supine:  1. Sample obtained 8-9 a.m.; 2. Fasting starting at midnight; 3. Normal sodium diet (100-200 mEq/day) for at least three days; 4.  Receiving no medications known to affect renin-aldosterone system. Upright: 1. Samples obtained before noon (after at least two hours in upright position); 2.  Normal sodium diet (100-200 mEq/day) for at least three days; 3. Receiving no medications known to affect renin-aldosterone system.  Contact Medical Director for more information.

Collect:  One 5 mL lavender (EDTA) or pink (K2EDTA).
Pediatric Collect/Transport: 0.6 mL plasma, frozen.

Storage/Transport Temperature:  2 mL plasma, frozen. (Min: 1.2 mL)  Submit specimen in an ARUP Standard Transport Tube.

Remarks:  CRITICAL FROZEN.  Separate specimens must be submitted when multiple tests are ordered.  Do not refrigerate.  Do not collect in refrigerated tubes. Separate plasma from cells and freeze immediately. Specimen should be drawn between 7:00 - 10:00 a.m.  If an upright specimen is collected, patient should be upright (seated or standing) for at least two hours. 

Unacceptable Conditions:  Serum.  Specimens collected in heparin, citrate, or oxalate.  Refrigerated specimens. Hemolyzed specimens.

Stability (collection to initiation of testing):  After separation from cells: Ambient: 6 hours; Refrigerated: Unacceptable; Frozen: 1 month
Reference Interval:
 
Adult, normal sodium diet Children, normal sodium diet, supine:  Children, normal sodium diet, upright: 
Supine: 0.2-1.6 ng/mL/hr
Upright: 0.5-4.0 ng/mL/hr 		Newborn (1-7 days): 2.0-35.0 ng/mL/hr
Cord blood: 4.0-32.0 ng/mL/hr
1-12 months: 2.4-37.0 ng/mL/hr
13 months-3 years:1.7-11.2 ng/mL/hr
4-5 years:1.0-6.5 ng/mL/hr
6-10 years: 0.5-5.9 ng/mL/hr
11-15 years: 0.5-3.3 ng/mL/hr 		0-3 years: Not Available
4-5 years: Less than or equal to 15 ng/mL/hr
6-10 years: Less than or equal to 17 ng/mL/hr
11-15 years: Less than or equal to 16 ng/mL/hr

Interpretive Data: Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen. Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.
CPT Code(s): 84244
Cross References: Plasma Renin Activity
 
 

 

 

 
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