ARUP's Laboratory Test Directory

Aldosterone/Renin Activity Ratio : 0070073

Mnemonic: A/RA

Methodology: Quantitative Radioimmunoassay
Performed: Sun-Sat
Reported: 1-5 days
Specimen Required: Patient Prep: Supine: 1. Both specimens should be obtained between 8 a.m. and 10 a.m. (after at least two hours in supine position); 2. Normal sodium diet (100-200 mEq/day) for at least three days; 3. Receiving no medications known to affect renin-aldosterone system.
Upright: 1. Both specimens should be obtained before noon (after at least two hours in upright position, seated or standing); 2. Normal sodium diet (100-200 mEq/day) for at least three days; 3. Receiving no medications known to affect renin-aldosterone system.
Contact Medical Director if more information is needed.

Collect: From either a supine or upright patient, serum separator tube or green (sodium or lithium heparin) AND lavender (EDTA) or pink (K2EDTA). Do not collect in refrigerated tubes.

Specimen Preparation: Separate from cells ASAP. Transfer 1 mL serum or heparinized plasma AND 2 mL EDTA plasma to individual ARUP Standard Transport Tubes and freeze immediately. (Min: 0.5 mL serum or heparinized plasma AND 1.2 mL EDTA plasma)

Storage/Transport Temperature: CRITICAL FROZEN. Separate specimens must be submitted when additional tests are ordered.

Unacceptable Conditions: Refrigerated plasma. Hemolyzed specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 1 month
Reference Interval:
 
Test Number Components Reference Interval
0070015Aldosterone, Serum Effective May 16, 2011
 
Age Posture Unspecified Supine Upright
0-6 days 5.0-102.0 ng/dL   
1-3 weeks 6.0-179.0 ng/dL   
1-11 months 7.0-99.0 ng/dL   
1-2 years 7.0-93.0 ng/dL   
3-10 years 4.0-44.0 ng/dL   
11-14 years 4.0-31.0 ng/dL   
15 years and older Less than or equal to 31.0 ng/dL Less than or equal to 16.0 ng/dL 4.0-31.0 ng/dL
0070105Renin Activity  
 
Adult, normal sodium diet Children, normal sodium diet, supine:  Children, normal sodium diet, upright: 
Supine: 0.2-1.6 ng/mL/hr Newborn (1-7 days): 2.0-35.0 ng/mL/hr 0-3 years: Not Available
Upright: 0.5-4.0 ng/mL/hr Cord blood: 4.0-32.0 ng/mL/hr 4-5 years: Less than or equal to 15 ng/mL/hr
 1-12 months: 2.4-37.0 ng/mL/hr 6-10 years: Less than or equal to 17 ng/mL/hr
 13 months-3 years:1.7-11.2 ng/mL/hr 11-15 years: Less than or equal to 16 ng/mL/hr
 4-5 years:1.0-6.5 ng/mL/hr  
 6-10 years: 0.5-5.9 ng/mL/hr  
 11-15 years: 0.5-3.3 ng/mL/hr  
 Aldosterone/Renin Activity Calculation Effective May 16, 2011

Less than 25
An Aldosterone/Renin Activity Ratio of greater than 25 is suggestive of hyperaldosteronism if the aldosterone concentration is greater than 15 ng/dL.
 
CPT Code(s): 82088; 84244