ARUP's Laboratory Test Directory
| 0060201: Antimicrobial Susceptibility - MIC, Individual |
| Test Mnemonic: MA MIC | |
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Methodology: Gradient Diffusion (E-Test) or Broth Microdilution
Performed: Sun-Sat Reported: 1-3 days |
| Specimen Required: | |
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Collect: Actively growing isolated organism, in pure culture, on agar slant or in bacterial transport media. Indicate isolate identification and specimen source.
Transport: Organism in pure culture in a sealed container at 20-25°C. Submit specimen according to Biological Substance, Category B, shipping guidelines. Pediatric Collection/Transport: Submit specimen according to Biological Substance, Category B, shipping guidelines. Remarks: Indicate any other pertinent information. Individual antibiotics and organism identification must be specified. Unacceptable Conditions: Mixed cultures or nonviable organisms. Stability: Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable |
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| Reference Interval: |
| Susceptible, intermediate, or resistant. |
| Note: | |
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The MIC is defined as the lowest concentration of an antibiotic which will inhibit the (in vitro) growth of an infectious organism. Results are reported in micrograms per mL. The interpretation of in vitro data is based on achievable serum concentrations, which may vary depending on dose, route of administration, degree of protein binding, site of infection, age and weight of the patient, state of health of the patient, and other factors. Reporting of MICs can provide the physician with precise information regarding the infectious organism's degree of susceptibility. When this information is coupled with the physician's knowledge of the site and severity of the infection, as well as the pharmacology of antibiotics, a rational choice of the most appropriate antibiotic can be made to suit the individual patient. With the quantitative MIC: (1) susceptibility can be determined for dosages and routes of administration other than those usually prescribed and (2) susceptibility can more accurately be related to the achievable antibiotic concentration in urine, bile, CSF, and other body fluids which may vary widely from the achievable concentration in serum. This test will bill per antibiotic tested. Susceptibility panels are available for certain organisms. Refer to Antimicrobial Susceptibility by organism type. For organisms where panels are not available, specific agent(s) to be tested must be indicated. For serious infections with coagulase-negative staphylococci other than S. epidermidis, testing for the presence of mecA may be appropriate and will be performed in order to interpret the results for b-lactam agents. Daptomycin MIC is available for testing MRSA or VRE. An additional handling fee will be billed for all organisms submitted that are not in pure culture as indicated in the specimen requirements. |
| CPT Code(s): | |
| 87181 Gradient dilution or 87186 Broth dilution |