ARUP's Laboratory Test Directory
| 0051256: Alpha-1-Antitrypsin & A1A Genotype with Reflex to Phenotype |
| Test Mnemonic: A1A GENO | |
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Methodology: Immunoturbidimetric Polymerase Chain Reaction/Fluorescent Resonance Energy Transfer
Performed: Mon, Thu Reported: 2-10 days |
| Specimen Required: | |
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Collect: One 4 mL PST or SST and one 5 mL whole blood lavender (EDTA) or pink (K2EDTA).
Transport: 0.5 mL serum or plasma and 5 mL whole blood at 2-8°C. Pediatric Collection/Transport: 0.2 mL serum or plasma and 1 mL whole blood at 2-8°C. Remarks: For serum and plasma: Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP. Unacceptable Conditions: Hemolyzed specimens. Stability: Serum Sample: Ambient: 8 hours; Refrigerated: 5 days; Frozen: 2 weeks Whole Blood Sample: Ambient: 3 days; Refrigerated: 1 week; Frozen: Unacceptable |
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| Interpretive Data: | |
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Refer to report.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com. Please refer to Statement C in the Compliance Statements section in the front of the Laboratory Test Directory. |
| Note: | |
| Alpha-1-antitrypsin serum protein concentration determination and A1A genotyping are performed on all specimens. If two deficiency alleles (ZZ, SZ, or SS) are detected, then testing is complete. If the protein concentration is less then 100 mg/dL and only one or no deficiency allele is detected by A1A genotyping, then phenotyping will be performed. |
| CPT Code(s): | |
| 82103 A1A; 83890 Isolation; 83898 x2 Amplification; 83896 x4 Nucleic acid probes; 83912 Interpretation and report. If reflexed, add 82104 Phenotype. Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders. |