ARUP's Laboratory Test Directory

Herpes Simplex Type 1 & Type 2 Glycoprotein G-Specific Antibodies, IgG by ELISA (HerpeSelect®) : 0051152

Mnemonic: HERP PAN 2

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimen. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Stability (collection to initiation of testing): Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval:
 
Test Number Components Reference Interval
0050292Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA (HerpeSelect®) 0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.10 IV: Equivocal - Questionable presence of IgG antibody to HSV type 1.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past HSV infection.
0050294Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA (HerpeSelect®) 0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
0.90-1.10 IV: Equivocal - Questionable presence of IgG antibody to HSV type 2.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or past HSV infection.

Interpretive Data: Individuals infected with HSV may not exhibit detectable IgG antibody to glycoprotein G in the early stages of infection, and 5-10% of infections may occur with glycoprotein G deficient virus.  Detection of antibody presence in these cases may only be possible using a non-type specific screening test.
CPT Code(s): 86695; 86696
Cross References: HerpeSelect® (Herpes Simplex Type 1 & Type 2 Glycoprotein G-Specific Antibodies, IgG by ELISA (HerpeSelect®)) , HSV (Herpes Simplex Type 1 & Type 2 Glycoprotein G-Specific Antibodies, IgG by ELISA (HerpeSelect®))