ARUP's Laboratory Test Directory

Ganglioside (asialo-GM1, GM1, GM2, GD1a, GD1b, & GQ1b) Antibody, IgG/IgM : 0051033

Mnemonic: GM1 COMBI

Methodology: Enzyme-Linked Immunosorbent Assay
Performed: Tue, Fri
Reported: 1-6 days
Specimen Required: Collect: One 4 mL serum separator tube.

Storage/Transport Temperature: 1 mL serum, frozen. (Min: 0.1 mL) If MAG Ab is ordered on the same patient, submit two 1 mL aliquots, frozen. Submit specimen in an ARUP Standard Transport Tube.

Remarks: CRITICAL FROZEN. Separate serum from cells ASAP.

Unacceptable Conditions: Ambient and refrigerated specimens. Plasma and other body fluids. Heat-inactivated, severely lipemic, contaminated, or hemolyzed specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 year
Reference Interval:
Test Number Components Reference Interval
Ganglioside (asialo-GM1) Antibody, IgG/IgM 29 IV or less: Negative
30-50 IV: Weak Positive
51-150 IV: Positive
151 IV or greater: Strong Positive
Ganglioside (GM1) Antibody, IgG/IgM 29 IV or less: Negative
30 IV-50 IV: Weak Positive
51 IV-150 IV: Positive
151 IV or greater: Strong Positive
Ganglioside (GM2) Antibody, IgG/IgM 29 IV or less: Negative
30 IV-50 IV: Weak Positive
51 IV-150 IV: Positive
151 IV or greater: Strong Positive
Ganglioside (GD1a) Antibody, IgG/IgM 29 IV or less: Negative
30 IV-50 IV: Weak Positive
51 IV-150 IV: Positive
151 IV or greater: Strong Positive
Ganglioside (GD1b) Antibody, IgG/IgM 29 IV or less: Negative
30 IV-50 IV: Weak Positive
51 IV-150 IV: Positive
151 IV or greater: Strong Positive
Ganglioside (GQ1b) Antibody, IgG/IgM 29 IV or less: Negative
30 IV-50 IV: Weak Positive
51 IV-150 IV: Positive
151 IV or greater: Strong Positive

Interpretive Data: Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) and the neutral glycolipid, asialo-GM1 are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. GD1a antibodies are associated with different variants of Guillain-Barrsyndrome (GBS) particularly acute motor axonal neuropathy while GD1b antibodies are predominantly found in sensory ataxic neuropathy syndrome. Anti-GQ1b antibodies are seen in more than 80% of patients with Miller-Fisher syndrome and may be elevated in GBS patients with ophthalmoplegia. The role of isolated anti-GM2 antibodies is unknown. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

Please refer to Statement D in the Compliance Statements section in the front of the Laboratory Test Directory.
CPT Code(s): 83516 Asialo GM1; 83516 GM1; 83516 GM2; 83516 GD1a, 83516 GD1b; 83516 GQ1b
 
 

 

 

 
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