ARUP's Laboratory Test Directory

Histone Antibody, IgG : 0050860

Mnemonic: AHA

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Mon, Wed-Sat
Reported: 1-3 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Plasma or urine. Contaminated specimens. Grossly hemolyzed, icteric, or lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
Effective May 16, 2011
 
0.9 units or less Negative
1.0-1.5 units Weak Positive
1.6-2.5 units Moderate Positive
2.6 units or greater Strong Positive

Note: Histone antibodies are present in 20-55% of idiopathic systemic lupus erythematosus (SLE) and 80-95% of drug-induced SLE. They occur in less than 20% of other types of connective tissue diseases.
CPT Code(s): 83516
Cross References: Anti-Histone Antibodies (Histone Antibody, IgG), Antihistone Antibodies (Histone Antibody, IgG), Drug Induced SLE (Histone Antibody, IgG)