Reference Interval:
| Test Number
| Components
| Reference Interval
| | | Histoplasma Mycelia Antibody by CF
| < 1:8
| | | Histoplasma Yeast Antibody by CF
| < 1:8
|
|
| Interpretive Data: |
An antibody titer greater than or equal to 1:8 is generally considered presumptive evidence of histoplasmosis. Greater than 1:32 or rising titers indicate strong presumptive evidence of histoplasmosis.
Yeast phase is regarded as more sensitive. Approximately 90-95% of cases have positive titers to one or both antigens. Titers to mycelial antigen are higher in chronic infection. Cross-reactions, usually at lower titers, may occur with other fungal disease. Rising titers suggest progression of infection. Skin tests in individuals previously exposed may cause titer elevation in 17-20% of cases.
|
| Note: |
Negative fungal serology does not rule out the possibility of current infection.
|
| CPT Code(s): |
86698 Histoplasma mycelia; 86698 Histoplasma yeast
|