ARUP's Laboratory Test Directory

Cytomegalovirus Antibodies, IgG and IgM : 0050622

Mnemonic: CMV PAN

Ordering Recommendation: Aids in discriminating between current and past cytomegalovirus infection in immunocompetent individuals.
Methodology: Semi-Quantitative Chemiluminescent Immunoassay
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect: Serum separator tube.Also acceptable: Serum from umbilical cord blood

Specimen Preparation: Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Urine. Contaminated, hemolyzed, or heat-inactivated specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
 
Test Number Components Reference Interval
0050165Cytomegalovirus Antibody, IgG  
 
0.59 U/mL or less: Not Detected.
0.60-0.69 U/mL: Indeterminate - Repeat testing in 10-14 days maybe helpful.
0.70 U/mL or greater: Detected.
0050553Cytomegalovirus Antibody, IgM  
 
29.9 AU/mL or less: Not Detected.
30.0-34.9 AU/mL: Indeterminate - Repeat testing in 10-14 days may be helpful.
35.0 AU/mL or greater: Detected - IgM antibody to CMV detected, which may indicate a current or recent infection.  However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
 
Interpretive Data: CMV serology is not useful for the evaluation of active or reactivated infection in immunocompromised patients. Molecular diagnostic tests (i.e., PCR) are preferred in these cases.
Note: This test should not be used for blood donor screening, associated re-entry protocols, or for screening Human Cell, Tissues and Cellular and Tissue-Based Products (HCT/P).
CPT Code(s): 86644; 86645
Cross References: CMV Antibodies (Cytomegalovirus Antibodies, IgG & IgM)