ARUP's Laboratory Test Directory

GM1 Antibody Panel : 0050591

Mnemonic: GM1 PAN

Methodology: Enzyme-Linked Immunosorbent Assay
Performed: Tue, Fri
Reported: 1-5 days
Specimen Required: Collect: One 4 mL serum separator tube.

Storage/Transport Temperature: 1 mL serum, frozen. (Min: 0.1 mL) If MAG Ab is ordered on the same patient, submit two 1 mL aliquots, frozen. Submit specimen in an ARUP Standard Transport Tube.

Remarks: CRITICAL FROZEN. Separate serum from cells ASAP.

Unacceptable Conditions: Ambient or refrigerated specimens. Plasma and other body fluids. Heat-inactivated, severely lipemic, contaminated, or hemolyzed specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 year
Reference Interval:
Test Number Components Reference Interval
GM1 Antibody IgG 29 IV or less: Negative
30-50 IV: Weak positive
51-150 IV: Positive
151 IV or greater: Strong positive
GM1 Antibody, IgM 29 IV or less: Negative
30-50 IV: Weak positive
51-150 IV: Positive
151 IV or greater: Strong positive
Asialo GM1 Antibody, IgG 29 IV or less: Negative
30-50 IV: Weak positive
51-150 IV: Positive
151 IV or greater: Strong positive
Asialo GM1 Antibody, IgM 29 IV or less: Negative
30-50 IV: Weak positive
51-150 IV: Positive
151 IV or greater: Strong positive

Interpretive Data: Elevated antibody levels to ganglioside-monosialic acid (GM1) and the neutral glycolipid, asialo GM1 are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

Please refer to Statement D in the Compliance Statements section in the front of the Laboratory Test Directory.
CPT Code(s): 83516 GM1 G; 83516 GM1 M; 83516 Asialo GM1 G; 83516 Asialo GM1 M
Cross References: Anti-GM1 Antibody Panel, Ganglioside-monosialic Acid Ab
 
 

 

 

 
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