ARUP's Laboratory Test Directory

Ganglioside (GM1) Antibodies, IgG and IgM : 0050591
[ image for: Additional Technical Information]
Additional Technical Information
  


Mnemonic: GM1 PAN

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Mon, Wed, Fri
Reported: 1-4 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.3 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Room temperature specimens. Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: Unacceptable; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval:
Test Number Components Reference Interval
GM1 Antibody IgG 29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong positive
GM1 Antibody, IgM 29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong positive

Interpretive Data: Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

See Compliance Statement D: www.aruplab.com/CS
CPT Code(s): 83516 x2
Cross References: Anti-GM1 Antibody Panel (Ganglioside (GM1) Antibodies, IgG and IgM), Ganglioside-Monosialic Acid Ab (Ganglioside (GM1) Antibodies, IgG and IgM)