Reference Interval:
0.89 IV or less: Negative - No clinically significant level of Toxoplasma gondii IgM antibody detected.
0.90-1.09 IV: Equivocal - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive - Significant level of Toxoplasma gondii IgM antibody detected and may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
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| Interpretive Data: |
This test is performed using the Siemens Immulite 2000 chemiluminescent immunoassay. As suggested by the CDC, any equivocal or positive Toxoplasma gondii IgM result should be retested in parallel with a specimen collected 1-3 weeks later. Further confirmation may be necessary using a different assay from another reference laboratory specializing in toxoplasmosis testing, such as Palo Alto Medical Foundation (Remington),where the IgM ELISA should be ordered or, as indicated, the Toxoplasma Serologic Profile. Caution should be exercised in the use of IgM antibody levels in prenatal screening. Any positive results in pregnant patients, that are confirmed positive by a second reference laboratory, should be evaluated by amniocentesis and PCR testing for Toxoplasma gondii.
For male and non-pregnant female patients with equivocal or positive Toxoplasma gondii IgM results, PCR may also be useful if a specimen can be collected from an affected body site.
For additional information, refer to the CDC website: www.cdc.gov/parasites/toxoplasmosis/health_professionals/index.html.
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| CPT Code(s): |
86778
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