ARUP's Laboratory Test Directory

0050292: Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA (HerpeSelect®)

Test Mnemonic: HERP I
Methodology: Enzyme-Linked Immunosorbent Assay

Performed: Sun-Sat

Reported: 1-2 days

Specimen Required:  
Collect: One 4 mL SST.

Transport: 0.5 mL serum at 2-8°C.  (Min: 0.2 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 0.1 mL serum at 2-8°C.

Remarks: Separate serum from cells ASAP.  Acute and convalescent specimens must be labeled as such; parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Please mark specimen plainly as "acute" or "convalescent."  

Unacceptable Conditions: Severely lipemic, contaminated, heat-inactivated, or hemolyzed specimens.

Stability: After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval:
0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.10 IV: Equivocal - Questionable presence of IgG antibody to HSV type 1.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past HSV infection.

Interpretive Data:
Individuals infected with HSV may not exhibit detectable IgG antibody to glycoprotein G in the early stages of infection and 5-10% of infections may occur with glycoprotein G-deficient virus.  Detection of antibody presence in these cases may only be possible using a nontype-specific screening test.



CPT Code(s):
86695