ARUP's Laboratory Test Directory

0050185: Cryoglobulin, Qualitative

Test Mnemonic: CRYGB
Methodology: Cold Precipitation

Performed: Sun-Sat

Reported: 3-5 days

Specimen Required:  
Collect: Whole blood must be drawn in a pre-warmed (37°C) syringe and kept at 37°C. Immediately after blood has been obtained, transfer specimen to a pre-warmed (37°C) plain red and keep specimen at 37°C until clotting is complete. Specimen may be drawn directly into a pre-warmed collection tube and maintained at 37°C until centrifugation. Let clot for one hour at 37°C. Separate serum from cells using a 37°C centrifuge, if possible.

Transport: 3 mL serum at 20-25°C. (Min: 3 mL)  Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 1 mL serum at 20-25°C.

Remarks: Fasting specimen recommended. Do not refrigerate or freeze at any time.  Proper collection and transport of specimen is critical to the outcome of the assay. Quantities less than 3 mL may affect the sensitivity of the assay.

Unacceptable Conditions: Refrigerated or frozen specimens.  Separator tubes.  Lipemic or grossly hemolyzed specimens.

Stability: After separation from cells: Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable

Reference Interval:
Negative at 72 hours.

Note:
The sample is examined daily for the presence or absence of cryoglobulins over a period of three days. Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular diseases, hepatitis C infection and infections such as infectious mononucleosis and cytomegalovirus disease. They may also be found in low levels in apparently healthy individuals.

CPT Code(s):
82595

 

 

 
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