ARUP's Laboratory Test Directory
| 0050185: Cryoglobulin, Qualitative |
| Test Mnemonic: CRYGB | |
|
Methodology: Cold Precipitation
Performed: Sun-Sat Reported: 3-5 days |
| Specimen Required: | |
|
Collect: Whole blood must be drawn in a pre-warmed (37°C) syringe and kept at 37°C. Immediately after blood has been obtained, transfer specimen to a pre-warmed (37°C) plain red and keep specimen at 37°C until clotting is complete. Specimen may be drawn directly into a pre-warmed collection tube and maintained at 37°C until centrifugation. Let clot for one hour at 37°C. Separate serum from cells using a 37°C centrifuge, if possible.
Transport: 3 mL serum at 20-25°C. (Min: 3 mL) Submit specimen in an ARUP Standard Transport Tube. Pediatric Collection/Transport: 1 mL serum at 20-25°C. Remarks: Fasting specimen recommended. Do not refrigerate or freeze at any time. Proper collection and transport of specimen is critical to the outcome of the assay. Quantities less than 3 mL may affect the sensitivity of the assay. Unacceptable Conditions: Refrigerated or frozen specimens. Separator tubes. Lipemic or grossly hemolyzed specimens. Stability: After separation from cells: Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable |
|
| Reference Interval: |
| Negative at 72 hours. |
| Note: | |
| The sample is examined daily for the presence or absence of cryoglobulins over a period of three days. Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular diseases, hepatitis C infection and infections such as infectious mononucleosis and cytomegalovirus disease. They may also be found in low levels in apparently healthy individuals. |
| CPT Code(s): | |
| 82595 |