ARUP's Laboratory Test Directory

0030182: Protein C & S Panel, Functional

Test Mnemonic: C/S PANEL
Methodology: Clotting

Performed: Sun-Sat

Reported: 1-2 days

Specimen Required:  
Collect: Two 5 mL (lt. blue sodium citrate).  (Min: two 3 mL) Refer to the Hemostasis/Thrombosis Specimens section in the front of this User's Guide for specimen collection instructions.

Transport: 4 mL platelet-poor plasma, frozen.  (Min: 2 mL) Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 1.5 mL platelet-poor plasma, frozen.

Remarks: CRITICAL FROZEN.  Separate specimens must be submitted when multiple tests are ordered. List medications.

Unacceptable Conditions: Serum.  Nonfrozen or hemolyzed specimens.

Stability: Ambient: 2 hours; Refrigerated: 4 hours; Frozen: 2 weeks

Reference Interval:
80-203%
 
Test Number Components Reference Interval
0030113Protein C, Functional 1-4 days: 17-53%
5-29 days: 20-64%
30-89 days: 21-65%
90-179 days: 28-80%
180-364 days: 37-81%
1-6 years: 40-92%
7-9 years: 56-144%
10-11 years: 59-143%
12-13 years: 57-142%
14-15 years: 56-162%
16-17 years: 68-154%
18 years and older: 77-173%
0030114Protein S, Functional Male
1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-6 years: 62-120%
7-9 years: 64-141%
10-11 years: 68-180%
12-13 years: 65-143%
14-15 years: 66-149%
16-17 years: 75-157%
18 years and older: 66-143%

Female
1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-6 years: 62-120%
7-9 years: 58-154%
10-11 years: 68-140%
12-13 years: 60-150%
14-15 years: 53-147%
16-17 years: 51-150%
18 years and older: 57-131%
 

Interpretive Data:
Patients on oral anticoagulants will have decreased functional protein C/S values. Patients should be off oral anticoagulant therapy for two weeks for accurate measurement of functional protein C/S levels.

Interfering Factors: Artifactually decreased functional protein C/S values may be seen in patients with abnormally elevated levels of factor VIII. Artifactually increased functional protein C/S values may be seen in patients on heparin therapy.



CPT Code(s):
85303 Protein C functional; 85306 Protein S functional