ARUP's Laboratory Test Directory

Thrombotic Risk, Inherited Etiologies (Most Common) with Reflex to Factor V Leiden : 0030133

Mnemonic: THROM COM

Methodology: Refer to individual components
Performed: Refer to individual components
Reported: 2-7 days
Specimen Required: Collect:  One 5 mL lt. blue (sodium citrate) for factor VIII, PTT, AND one 5 mL lt. blue (sodium citrate) APC (Min: 5 mL), AND one 5 mL lavender (EDTA) prothrombin nucleotide, AND one 5 mL green (sodium or lithium heparin) for homocysteine (fasting sample is preferred for homocysteine).

Transport:  Two 2 mL aliquots platelet-poor plasma (lt. blue, sodium citrate), frozen for factor VIII, PTT, and APC (Min: 1 mL per aliquot) AND one 1 mL green (sodium or lithium heparin) (Min: 0.4 mL), frozen for homocysteine AND one 5 mL whole blood (lavender, EDTA) at 2-8for prothrombin nucleotide. (Min: 1mL)  Do not freeze whole blood.

Remarks:  Factor VIII is a CRITICAL FROZEN.

Unacceptable Conditions:  Refer to individual components.

Stability:  Refer to individual components.
Reference Interval:
 
Test Number Components Reference Interval
0030235Partial Thromboplastin Time 24-35 seconds
0030095Factor VIII, Activity 0-6 years: 56-191%
7-9 years: 76-199%
10-11 years: 80-209%
12-13 years: 72-198%
14-15 years: 69-237%
16-17 years: 63-221%
18 years and older: 56-191%
0099869Homocysteine, Total < 11 µmol/L, for both male and female
0056060Prothrombin (F2) G20210A Mutation Negative: This sample is negative for the factor II, prothrombin 20210A mutation.
 APC Resistance Profile Greater than 0.61
 Factor V Leiden by PCR & Fluorescence Monitoring Negative: The sample is negative for factor V Leiden, R506Q mutation.
 

Note: If APC resistance is normal, no further testing will be performed.  If APC resistance is abnormally low, then Factor V Leiden by PCR will be added. Additional charges may apply.
CPT Code(s): 85730 PTT; 85240 F8; 83090 tHcy; 83890 Isolation; 83898 Amplification; 83896 Nucleic acid probes; 83912 Int/report; 85307 APC; if reflexed, add 83890 Isolation; 83898 Amplification; 83896 Nucleic acid probes; 83912 Int/report - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.
 
 

 

 

 
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