Qinwen Mao, MD, PhD

Professor, University of Utah School of Medicine

Specialties

• Neuropathology

Education

• Medical Degree, Fourth Military Medical University, China
• MS in Histology, Fourth Military Medical University, China
• PhD in Physiology, Fourth Military Medical University, China
• Residency, Anatomic Pathology, University of Texas Southwestern Medical School
• Clinical Fellow in Neuropathology, University of Texas Southwestern Medical School

Certification/Affiliations

• Diplomate of the American Board of Pathology: Anatomic Pathology and Neuropathology

Research Interests

• Pathogenesis and management of Alzheimer’s disease; frontotemporal lobar degeneration
• Chronic traumatic encephalopathy
• Biomarker development for dementia

Awards

• Presidential Symposium & Presentation of the Top Abstracts, the American Society of Gene & Cell Therapy Annual Meeting, Minneapolis, Minnesota (2004)
• Travel Award, American Association of Neuropathologists Annual Meeting, San Diego, California (2008)
• A.D. Sobel–American Society for Investigative Pathology Education Fund Scholar for Outstanding Research in Experimental Pathology (2008)
• Outstanding Teacher, Science in Medicine Lecture, Northwestern University Feinberg School of Medicine, Chicago, Illinois (2014-2020)
• Travel Award, American Association of Neuropathologists Annual Meeting, Louisville, Kentucky (mentor) (2018)
• Eisenberg Scholar, Northwestern University (2018)
• Woman and Diversity Award, American Association of Neuropathologists Annual Meeting (mentor) (2020)
• Hirano Award for the Best Paper on Neurodegenerative Diseases, American Association of Neuropathologists Annual Meeting (mentor) (2020)

Recent Publications

Original Investigations

Gefen T, et al. Primary progressive aphasia has a unique signature distinct from dementia of the alzheimer's type and behavioral variant frontotemporal dementia regardless of pathology. J Neuropathol Exp Neurol. 2020;79(12):1379-1381.

Huang QQ, et al. Critical role of synovial tissue-resident macrophage niche in joint homeostasis and suppression of chronic inflammation. Sci Adv. 2021 Jan 6;7(2).

Walker JM, et al. Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. J Neuropathol Exp Neurol. 2021 Jan 20;80(2):102-111.

Kam KL, et al. Is Next-Generation Sequencing Alone Sufficient to Reliably Diagnose Gliomas? J Neuropathol Exp Neurol. 2020 Jul 1;79(7):763-766.

Du C, et al. The luciferase reporter system of the MMP12 endogenous promoter for investigating transcriptional regulation of the human MMP12 gene. Electronic Journal of Biotechnology. 2020; 43(1):55-61.

Jara JH, et al. MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology. J Neuroinflammation. 2019;16(1):196.

Zhang J, et al. A simple, efficient and economical method for isolating and culturing human umbilical cord bloodderived mesenchymal stromal cells. Mol Med Rep. 2019;20(6):5257-5264.

Zhu J, et al. Suppression of Progranulin Expression Leads to Formation of Intranuclear TDP-43 Inclusions In Vitro: A Cell Model of Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol. 2019;78(12):1124-1129.

Li Y, et al. Generation of a novel HEK293 luciferase reporter cell line by CRISPR/Cas9-mediated site-specific integration in the genome to explore the transcriptional regulation of the PGRN gene. Bioengineered. 2019;(1):98-107.

Mao Q, et al. FTLD-TDP With and Without GRN Mutations Cause Different Patterns of CA1 Pathology. J Neuropathol Exp Neurol. 2019 ;78(9):844-853.

Nishihira Y, et al. Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes. Acta Neuropathol. 2019;138(1):167-169.

Rogalski E, et al. Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases. Hippocampus. 2019;29(5):458-467.

Li Y, et al. A highly sensitive sandwich ELISA to detect CSF progranulin: A potential biomarker for CNS disorders. J Neuropathol Exp Neurol. 2019;78(5):406-415.

Maniar KP, et al. Accreditation council for graduate medical education (ACGME) self-study for pathology: one institution's experience and lessons learned. Arch Pathol Lab Med. 2019;143(10):1271-1277.

Shan L, et al. Establishment of a DGKθ endogenous promoter luciferase reporter HepG2 cell line for studying the transcriptional regulation of DGKθ gene. Appl Biochem Biotechnol. 2019;187(4):1344-1355.

Zhang D, et al. Somatostatin Receptor Ligand Therapy-A Novel Therapy for Neurocytoma. J Clin Endocrinol Metab. 2019;104(6):2395-2402.

Hojat A, et al. Procurement and Storage of Surgical Biospecimens. Methods Mol Biol. 2019;1897:65-76.

Chen H, et al. Aptazyme-mediated direct modulation of post-transcriptional sgRNA level for conditional genome editing and gene expression. J Biotechnol. 2018;288:23-29.

Li Z, et al. Establishment of a HEK293 cell line by CRISPR/Cas9-mediated luciferase knock-in to study transcriptional regulation of the human SREBP1 gene. Biotechnol Lett. 2018;40(11-12):1495-1506.

Li Y, et al. Establishing a dual knock-out cell line by lentivirus based combined CRISPR/Cas9 and Loxp/Cre system. Cytotechnology. 2018;70(6):1595-1605.

Shan L, et al. Establishment of a DGKθ endogenous promoter luciferase reporter HepG2 cell line for studying the transcriptional regulation of DGKθ gene. Appl Biochem Biotechnol. 2019;187(4):1344-1355.

Gefen T, et al. Combined Pathologies in FTLD-TDP Types A and C. J Neuropathol Exp Neurol. 2018;77(5):405-412.

Zhang J, et al. Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKtheta gene knockout. Mol Med Rep. 2018;17(2):2169-2176.

Huang QQ, et al. The Role of Macrophages in the Response to TNF Inhibition in Experimental Arthritis. J Immunol. 2018;200(1):130-138.

Zhang W, et al. Generation of apoptosis-resistant HEK293 cells with CRISPR/Cas mediated quadruple gene knockout for improved protein and virus production. Biotechnol Bioeng. 2017;114(11):2539-2549.

Mao Q, et al. Disease and region specificity of granulin immunopositivities in alzheimer disease and frontotemporal lobar degeneration. J Neuropathol Exp Neurol. 2017;76(11):957-968.

Li Y, et al. Biological function analysis of monoclonal antibodies against human granulins in vitro using U251 cells as a model. Protein Expr Purif. 2017;130:55-62.

Kovacs GG, et al. Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). J Neuropathol Exp Neurol. 2017;76(7):605-619.

Chen F, et al. Domain-specific monoclonal antibodies against human rev-erbbeta. Appl Biochem Biotechnol. 2017;182(3):978-989.

Zheng X, et al. Production and characterization of monoclonal antibodies against human nuclear protein. FAM76B. PLoS One. 2016;11(3).

Xiao D, et al. A novel luciferase knock-in reporter system for studying transcriptional regulation of the human Sox2 gene. J Biotechnol. 2016;219:110-116.

Li Y, et al. Development of a sensitive luciferase-based sandwich ELISA system for the detection of human extracellular matrix 1 protein. Monoclonal Antib Immunodiagn Immunother. 2016;35(6):273-279.

Li Y, et al. Production and characterization of domain-specific monoclonal antibodies against human ECM1. Protein Expr Purif. 2016;121:103-111.

Dai X, et al. Generation of Domain-Specific Monoclonal Antibodies Against Human Glutaredoxin3. Monoclon Antib Immunodiagn Immunother.2016;35(6):285-292.

Reviews and Case Reports

Kam K L, et al. Newly diagnosed enhancing lesions: Steroid initiation may impede diagnosis of lymphoma involving the central nervous system. J Clin Neurosci. 2020;81:61-64.

McCord MR, et al. Spinocerebellar Ataxia Type 3: A case report and literature review. J Neuropathol Exp Neurol. 2020;79(6):641-646.

Apple AC, et al. Sleep talking and primary progressive aphasia: case study and autopsy findings in a patient with logopenic primary progressive aphasia and dementia with Lewy bodies. BMJ Case Rep. 2019 May 27;12(5).

Muhammad N, et al. CAR T-cells for cancer therapy. Biotechnol Genet Eng Rev. 2017;33(2):190-226.

Hakar M, et al. Neuroendocrine carcinoma of the pineal parenchyma. The first reported case. J Clin Neurosci. 2017;35:68-70.

Ampie L, et al. Clinical attributes and surgical outcomes of angiocentric gliomas. J Clin Neurosci. 2016;28:117-122.