Fluorescence In Situ Hybridization (FISH)

ARUP offers FISH technology as a complement to classical cytogenetic techniques for well-characterized microdeletion/microduplication disorders, such as DiGeorge syndrome, as well as for unique or family-specific imbalances identified by microarray. Testing of oncology specimens, whether the sample is blood, bone marrow, fresh tissue, or paraffin block, is available. Many disease-specific FISH panels, as well as individual probes, can assist in the diagnosis and monitoring of patients with cancer.

Test # Test Name Additional Information Test Keywords
0040208 Aneuploidy Panel by FISH FISH (Constitutional)—Aneuploidy Panels FISHANEU, Down, Downs, Down's, Trisomy 21, Trisomy 18, Turner, Turner's, Turners, Klinefelter, Klinefelter's, Klinefelters, trisomy 13, newborn
2002297 Chromosome FISH, Prenatal FISH (Constitutional)—Aneuploidy Panels CHR FISHP, Down, Downs, Down's, Trisomy 21, Trisomy 18, Turner, Turner's, Turners, Klinefelter, Klinefelter's, Klinefelters, trisomy 13, prenatal, amnio, amniotic fluid, Insight, PN FISH
0040203 Chorionic Villus, FISH FISH (Constitutional)—Aneuploidy Panels FISHCVS, Down, Downs, Down's, Trisomy 21, Trisomy 18, Turner, Turner's, Turners, Klinefelter, Klinefelter's, Klinefelters, trisomy 13, prenatal, CVS
2002299 Chromosome FISH, Metaphase

Available probes:
1p36 deletion
4p-
5p-
15q11.2-13 duplication
22qter deletion (SHANK3)
Angelman
Cri-du-chat
DiGeorge
Kallman
Male detection (SRY)
Miller-Dieker (Lisencephaly)
Phelan McDermid
Prader-Willi
SHOX
Smith-Magenis
SRY
Steroid sulfatase deficiency (STS)
Velocardiofacial (VCF)
Williams (elastin)
Wolf-Hirschhorn

Please call a genetic counselor before ordering:
Acrocentric p-arm
X centromere
X inactivation locus (XIST)
Y centromere
Yp11.3
Yq12

 		Please specify which FISH probe you wish to order.

 FISH (Constitutional)—Individual Probes CHR FISHM, 1p36, 4p-, 5p-, angelman, cri-du-chat, DiGeorge, Kallman, SRY, Miller-Dieker, Lisencephaly, Phelan McDermid, Prader-Willi, SHOX, Smith-Magenis, Steroid sulfatase deficiency, STS, Velocardiofacial, VCF, VCFS, Williams, elastin, Wolf-Hirschhorn, Centromere, Yq12, Yp11.3, ichthyosis
2002301 Microarray Family Study by FISH

Used to determine the presence of a known deletion or duplication, previously identified by microarray in a family member. If the original array was not performed at ARUP, contact an ARUP genetic counselor prior to sending the sample.

 		Please call a genetic counselor before ordering. Genomic Microarray (FISH) ARRAY FAM, Array, CGH, aCGH, parental
2002647 Acute Lymphocytic Leukemia (ALL) Panel by FISH, Adult Oncology Studies, FISH—Blood and Bone Marrow Panels FISH A ALL, B-Cell Lymphoma, MYC BCR-ABL1, MLL, IGH@, TCF3, E2A
2002719 Acute Lymphocytic Leukemia (ALL) Panel by FISH, Pediatric Oncology Studies, FISH—Blood and Bone Marrow Panels FISH P ALL, Oncology, Bone Marrow , B-Cell Lymphoma, childhood, child, children, CEP4, CEP10, BCR-ABL1 MLL, ETV6-RUNX1, TEL-AML1
2002653 Acute Myelogenous Leukemia (AML) with Myelodysplastic Syndrome (MDS), or Therapy-Related AML, by FISH Oncology Studies, FISH—Blood and Bone Marrow Panels F TAML MDS, Myelodysplastic syndrome, Acute Myeloid Leukemia, EGR1, D7S486, MLL
2002384 Acute Myelogenous Leukemia Panel by FISH Oncology Studies, FISH—Blood and Bone Marrow Panels FISH AML P, Acute Myeloid Leukemia, AML, Myeloproliferative, MPD, PML-RARA, RUNX1T1-RUNX1, ETO-AML1, CBFB, MLL
2002295 Chromosome FISH, CLL Panel Oncology Studies, FISH—Blood and Bone Marrow Panels FISH CLLP, Chronic Lymphocytic Leukemia, CLL, Lymphoma Phenotyping, B-Cell Lymphomas, Tumor Markers, ATM, D12Z3, D13S319, TP53, p53
2006270 Chromosome FISH, Multiple Myeloma Panel Process and Hold Oncology Studies, FISH—Blood and Bone Marrow Panels MMF PR &HLD
2002378 Eosinophilia Panel by FISH Oncology Studies, FISH—Blood and Bone Marrow Panels FISH EOS P, Mast Cell Disease, Eosinophilic Diseases, Acute Myeloid Leukemia (AML), Myeloproliferative Neoplasms (MPN), PDGFRA-CHIC2-FIP1L1, PDGFRB, FGFR1, CBFB
2002650 Lymphoma (Aggressive) Panel by FISH Oncology Studies, FISH—Blood and Bone Marrow Panels FISH ALYMP, Lymphoma Phenotyping, B-Cell Lymphomas, Lymphoproliferative Disorders (LPD), BCL6, MYC, IGH@/BCL2
2002294 Multiple Myeloma Panel by FISH Oncology Studies, FISH—Blood and Bone Marrow Panels FISH MMP, Plasma Cell Dyscrasias, CKS1B, ASS1, CCND1-IGH@, IGH@, PML, TP53, FGFR3-IGH@, IGH@-MAF
2002709 Myelodysplastic Syndrome (MDS) Panel by FISH Oncology Studies, FISH—Blood and Bone Marrow Panels FISH MDS P, Myelodysplastic Syndrome (MDS), EGR1, D7S486, CEP8, D20S108
2002360 Myeloproliferative Disorders Panel by FISH Oncology Studies, FISH—Blood and Bone Marrow Panels FISH MPD P, Chronic Myelogenous Leukemia (CML), Myeloproliferative Neoplasms (MPN), PDGFRα-CHIC2-FIP1L1, PDGFRa-CHIC2-FIP1L1, PDGFRβ, FGFR1, ABL1-BCR
2002363 PML-RARA Translocation by FISH Oncology Studies, FISH—Blood and Bone Marrow Panels FISH PML, Acute Myeloid Leukemia (AML), Acute Promyelocytic Leukemia (APL), Tumor Markers
2002298 Chromosome FISH, Interphase

Location:
2p23 ALK rearrangement
3q27 BCL6 rearrangement
Chromosome 4 gain or loss
4q12 PDGFRA rearrangement
Chromosome 5q deletion
5q32 PDGFRB rearrangement
Chromosome 7q deletion/Monosomy 7
Chromosome 8 gain or loss
8p12
8q24
9p21 deletion
9q34
Chromosome 10 gain or loss
11q23
Trisomy 12
14q32
Chromosome 17 gain or loss
17p13.1 deletion
18q11.2 (Synovial sarcoma) rearrangement
19p13 Rearrangement
Chromosome 20q Deletion
22q12.2 (Ewing Sarcoma) rearrangement
Chromosomes X & Y Centromere
del(11)(q22.3) deletion
del(13)(q14.3) deletion
inv(16)(p13.3q22) CBFB rearrangement
t(11;14)(q12;q32) fusion
t(12;21)(p13;q22) fusion
t(14;16)(q32;q23.1) fusion
t(14;18)(q32;q21) fusion
t(15;17)(q22;q21) fusion
t(4;14)(p16;q32) fusion
t(8;21)(q22;q22) fusion
t(9;22)(q34;q11.2) Fusion 		Please specify which FISH probe you wish to order.

 Oncology Studies, FISH—Blood and Bone Marrow—by Location CHR FISHI, Oncology FISH Studies, Blood and Bone Marrow, Ewing Sarcoma, Neuroblastoma, Myelodysplastic Syndromes, Chronic Lymphocytic Leukemia (CLL), Sarcoma, Acute Lymphoblastic Leukemia (ALL), Chronic Myelogenous Leukemia (CML), Tumor Markers, Acute Myeloid Leukemia (AML), Myeloproliferative Neoplasms (MPN), Plasma Cell Dyscrasias, Lymphoma Phenotyping, B-Cell Lymphomas
2002461 Pancreatobiliary FISH Oncology Studies, FISH—Other PF, Pancreatic Cancer, Tumor Markers
8100600 UroVysion™ FISH Oncology Studies, FISH—Other UF, Bladder Cancer, Tumor Markers, urine
0049360 1p/19q Deletion by FISH Additional Technical Information Oncology Studies, FISH—Paraffin Block 1p19q, Oncology, Paraffin, Brain Tumors, Tumor
0049234 EGFR by FISH Additional Technical Information Oncology Studies, FISH—Paraffin Block EGFRFISH, Head and Neck Cancer, Lung Cancer, Brain Tumors
0049218 ERBB2 (HER-2/neu) Gene Amplification by FISH, Tissue Oncology Studies, FISH—Paraffin Block HER2FISH, Breast Cancer, Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu, pathvision, pathvysion
2001497 FOXO1 (FKHR) (13q14) Gene Rearrangement by FISH Oncology Studies, FISH—Paraffin Block FKHRFISH, Sarcoma, FOX, FOXO1, 13q14, alveolar rhabdomyosarcoma
2001536 IGH-BCL2 Fusion, t(14;18) by FISH for Detection in Follicular Lymphoma Oncology Studies, FISH—Paraffin Block B-Cell Lymphomas, Follicular lymphoma, Diffuse large B-cell lymphoma, FISH
2007226 IGH-CCND1 Fusion, t(11;14) by FISH Oncology Studies, FISH—Paraffin Block Mantle cell lymphoma, B-Cell Lymphomas, Plasma cell dyscrasias, Tumor Markers
2001538 IGH-MYC Fusion t(8;14) by FISH for Detection in Burkitt Lymphoma Additional Technical Information Oncology Studies, FISH—Paraffin Block Burkitt lymphoma, B-Cell Lymphomas
2003016 MDM2 Gene Amplification by FISH Additional Technical Information Oncology Studies, FISH—Paraffin Block MDM2 FISH, Sarcoma, Tumor Markers, MDM2, Murine Double Minute 2
2002345 MYC (8q24) Gene Rearrangement by FISH Additional Technical Information Oncology Studies, FISH—Paraffin Block Burkitt lymphomas, B-Cell Lymphomas, Double Hit lymphomas, Tumor Markers
2007227 MYCN (N-MYC) Gene Amplification by FISH Additional Technical Information Oncology Studies, FISH—Paraffin Block NMYC, Neuroblastoma, Tumor Markers
0040114 SYT-SSX t(X;18) Translocations by RT-PCR Additional Technical Information Oncology Studies, FISH—Paraffin Block SYTFISH, Sarcoma, Tumor Markers, Synovial Sarcoma