Molecular Testing in Lung Cancer for Determination of Patient Eligibility for Targeted Therapies

ARUP's lung cancer test menu is ideally suited to address gene mutations identified as actionable therapy targets. Faster turnaround times enable clinicians and patients to make timely, individualized treatment plans.


Lung Cancer Testing

KRAS Gene Mutation

Next-Generation Sequencing Panels

Test Name Solid Tumor Mutation Panel by NGS
Test Code 2007991
Test Information

Bundled Assays

Concurrent testing is performed for multiple single gene assays to reduce turnaround time and required tissue.

Test Name Lung Cancer Panel with KRAS
Test Code 2008895
Test Information EGFR and KRAS mutation detection run by pyrosequencing; ALK and ROS1 run concurrently by IHC.

Single Gene Assays

Mutation by pyrosequencing

Test Name KRAS Mutation Detection
Test Code 0040248
Test Information Covers exon 2 (codons 12 and 13) and exon 3 (codon 61)

EGFR Gene Mutation

Next-Generation Sequencing Panels

Test Name Solid Tumor Mutation Panel by NGS
Test Code 2007991
Test Information

Bundled Assays

Concurrent testing is performed for multiple single gene assays to reduce turnaround time and required tissue.

Test Name Lung Cancer Panel with KRAS
Test Code 2008895
Test Information EGFR and KRAS mutation detection run by pyrosequencing; ALK and ROS1 run concurrently by IHC.
Test Name Lung Cancer Panel
Test Code 2008894
Test Information EGFR mutation detection run by pyrosequencing; ALK and ROS1 run concurrently by IHC.

Single Gene Assays

Mutation by pyrosequencing

Test Name EGFR Mutation Detection
Test Code 2002440
Test Information Covers exons 18–21

EGFR T790M Gene Mutation

Circulating Cell-Free Tumor DNA Assays

Test Name EGFR T790M Mutation Detection in Circulating Cell-Free DNA by Digital Droplet PCR
Test Code 2012868
Test Information
  • Blood specimen type
  • Monitors the development of EGFR T790M drug-resistant mutation

Next-Generation Sequencing Panels

Test Name Solid Tumor Mutation Panel by NGS
Test Code 2007991
Test Information

Bundled Assays

Concurrent testing is performed for multiple single gene assays to reduce turnaround time and required tissue.

Test Name Lung Cancer Panel with KRAS
Test Code 2008895
Test Information EGFR and KRAS mutation detection run by pyrosequencing; ALK and ROS1 run concurrently by IHC.
Test Name Lung Cancer Panel
Test Code 2008894
Test Information EGFR mutation detection run by pyrosequencing; ALK and ROS1 run concurrently by IHC.

Single Gene Assays

Mutation by pyrosequencing

Test Name EGFR Mutation Detection
Test Code 2002440
Test Information Covers exons 18–21

ERBB2 Gene Mutation

Next- Generation Sequencing Panels

Test Name Solid Tumor Mutation Panel by NGS
Test Code 2007991
Test Information

ERBB4 Gene Mutation

Next-Generation Sequencing Panels

Test Name Solid Tumor Mutation Panel by NGS
Test Code 2007991
Test Information

ALK Gene Mutation

Next-Generation Sequencing Panels

Test Name Solid Tumor Mutation Panel by NGS
Test Code 2007991
Test Information

BRAF Gene Mutation

Next-Generation Sequencing Panels

Test Name Solid Tumor Mutation Panel by NGS
Test Code 2007991
Test Information

Single Gene Assays

Mutation by pyrosequencing

Test Name BRAF Codon 600 Mutation Detection
Test Code 2002498
Test Information Covers exon 15

MET Gene Mutation

Fluorescent In Situ Hybridization (FISH)

Test Name MET Gene Amplification by FISH
Test Code 2013082

PIK3CA Gene Mutation

Next-Generation Sequencing Panels

Test Name Solid Tumor Mutation Panel by NGS
Test Code 2007991
Test Information

AKT1 Gene Mutation

Next-Generation Sequencing Panels

Test Name Solid Tumor Mutation Panel by NGS
Test Code 2007991
Test Information

NRAS Gene Mutation

Next-Generation Sequencing Panels

Test Name Solid Tumor Mutation Panel by NGS
Test Code 2007991
Test Information

Single Gene Assays

Mutation by pyrosequencing

Test Name NRAS Mutation Detection
Test Code 2003123
Test Information Covers exon 2 (codons 12 and 13) and exon 3 (codon 61)

Additional Gene Mutations

Next-Generation Sequencing Panels

Test Name Solid Tumor Mutation Panel by NGS
Test Code 2007991
Test Information

ALK Gene Fusions/Translocations

Immunohistochemistry (IHC)

Test Name ALK (D5F3) with Reflex to FISH
Test Code 2011431
Test Information If IHC is positive or equivocal, the sample is reflexed to FISH for confirmation.

Fluorescent In Situ Hybridization (FISH)

Test Name ALK Gene Rearrangements by FISH
Test Code 2006102

ROS1 Gene Fusions/Translocations

Immunohistochemistry (IHC)

Test Name ROS1 with Interpretation with Reflex to FISH
Test Code 2008414
Test Information
  • If IHC is equivocal, the sample is reflexed to FISH.

Fluorescent In Situ Hybridization (FISH)

Test Name ROS1 by FISH
Test Code 2008418

RET Gene Fusions/Translocations

Fluorescent In Situ Hybridization (FISH)

Test Name RET Gene Rearrangements by FISH
Test Code 2012654

PD-L1 Protein Expression

Immunohistochemistry (IHC)

Test Name PD-L1 22C3 pharmDx by Immunohistochemistry with Interpretation, pembrolizumab (KEYTRUDA)
Test Code 2013284
Test Information Aids in prediction of response to KEYTRUDA (pembrolizumab) for patients with non-small cell lung cancer (NSCLC)
Test Name PD-L1 28-8 pharmDx by Immunohistochemistry with Interpretation, nivolumab (OPDIVO)
Test Code 2013684
Test Information Aids in prediction of response to OPDIVO (nivolumab) for patients with non-squamous non-small cell lung cancer (NSCLC) or melanoma

ALK Protein Expression

Bundled Assays

Concurrent testing is performed for multiple single gene assays to reduce turnaround time and required tissue.

Test Name Lung Cancer Panel with KRAS
Test Code 2008895
Test Information EGFR and KRAS mutation detection run by pyrosequencing; ALK and ROS1 run concurrently by IHC.
Test Name Lung Cancer Panel
Test Code 2008894
Test Information EGFR mutation detection run by pyrosequencing; ALK and ROS1 run concurrently by IHC.

Immunohistochemistry (IHC)

Test Name ALK (D5F3) with Interpretation
Test Code 2007324
Test Information More cost effective than FISH testing
Test Name ALK (D5F3) with Reflex to FISH
Test Code 2011431
Test Information If IHC is positive or equivocal, the sample is reflexed to FISH for confirmation.

ROS1 Protein Expression

Bundled Assays

Concurrent testing is performed for multiple single gene assays to reduce turnaround time and required tissue.

Test Name Lung Cancer Panel with KRAS
Test Code 2008895
Test Information EGFR and KRAS mutation detection run by pyrosequencing; ALK and ROS1 run concurrently by IHC.
Test Name Lung Cancer Panel
Test Code 2008894
Test Information EGFR mutation detection run by pyrosequencing; ALK and ROS1 run concurrently by IHC.

Immunohistochemistry (IHC)

Test Name ROS1 with Interpretation with Reflex to FISH
Test Code 2008414
Test Information If IHC is equivocal, the sample is reflexed to FISH.

Additional Resources

ARUP’s Lung Cancer Experts are nationally and internationally recognized pathologists, subspecialty-qualified clinicians, and board-certified clinical scientists.

ARUP Consult® is a laboratory test selection support tool with more than 2,000 lab tests categorized into disease-related topics and algorithms. ARUP Consult Lung Cancer

Gene Coverage

ARUP Links

For additional information, please call ARUP Client Services at (800) 522-2787 and mention keyword: Lung Cancer.