New Test Highlights
3004517 Paraneoplastic Reflexive Panel, CSF
This new panel includes testing for ANNA-1 (Hu), ANNA-2 (Ri), PCCA-1 (Yo), PCCA-Tr/DNER, amphiphysin, SOX1, and CV2.1 antibodies.
DPPX antibodies are uniquely present in some cases of PNSs. They may be found in a subset of patients with autoimmune encephalitis and may occur with or without an associated tumor. ARUP offers DPPX testing in our panels and as a standalone reflex test.
3004510 Amphiphysin Antibody, IgG, CSF
Amphiphysin antibodies are considered classic antibodies for PNSs and are diagnostic for the condition. Amphiphysin antibodies are mainly associated with small cell lung cancer and breast tumors. ARUP offers amphiphysin testing in our panels and as a standalone reflex test.
Test Information
When Should Testing Be Ordered?
Testing should be ordered whenever PNSs or related conditions are suspected (e.g., in the case of a patient with suggestive symptoms and another autoimmune disease, as it is common for patients to have multiple autoimmune conditions). Testing may also be used to guide treatment. For more information about when testing may be appropriate, visit the ARUP Consult Paraneoplastic Neurologic Syndromes and Associated Disorders and Autoimmune Neuropathies - Neuropathic Disease topics.
Why Is Antibody Testing Important?
Antibody testing for PNSs and related conditions may serve several important functions. For example, antibody testing is used to:
- Aid in the diagnosis of PNSs and/or related disorders
- Direct a focused search for cancer
- Differentiate autoimmune neurologic diseases from the neurotoxic effects of chemotherapy
- Monitor the immune response of seropositive patients during cancer therapy
- Detect early evidence of cancer recurrence in previously seropositive patients
Why Test With ARUP?
Testing options to meet your needs: ARUP offers multiple testing options for PNSs and related conditions so that you can configure your testing strategy to the clinical situation. Options for antibody tests include:
- Comprehensive panels for the evaluation of paraneoplastic autoimmune neurologic syndromes, neuromuscular junction disorders, and/or encephalitis in the presence or absence of malignancy
- Small, cost-effective, directed panels
- Standalone tests that enable tracking of a single antibody over time
To assist you with test selection, ARUP provides visual overviews of testing options for PNSs:
- Paraneoplastic Neurologic Syndromes Testing Algorithm - Serum
- Paraneoplastic Neurologic Syndromes Testing Algorithm - CSF
Comprehensive clinical coverage: ARUP’s tests include antibodies with significant clinical impact that cover an estimated 95–99% of disease cases and minimize redundancy.
For an overview of the antibodies included in ARUP’s panels, see:
- ARUP Autoimmune Neurology Panel Components Table
- ARUP Consult Paraneoplastic Neurologic Syndromes and Associated Disorders topic
- ARUP Consult Autoimmune Neuropathies - Neuropathic Disease topic
FAQs
ARUP selects antibodies for its test menu based on rigorous scientific evidence, with the goal of ensuring the detection of well-characterized antibodies with significant clinical impact. New antibodies are regularly evaluated, and testing is added to ARUP’s menu based on the latest recommendations and clinical relevance as demonstrated by emerging literature.
ARUP offers a comprehensive assortment of standalone and panel tests for clinically significant antibodies that cover 95–99% of disease cases. These tests can be configured to meet your needs, minimize redundancy, and ensure cost-effectiveness. A significant number of these tests overlap with panel test offerings from our competitors.
Although ARUP Laboratories offers tests that detect an estimated 95–99% of disease cases, some tests are not currently offered as standalone tests. For example:
- A standalone test for N-type voltage-gated calcium channel (VGCC) antibody is not offered. This antibody overlaps with P/Q-type VGCC autoantibodies, and tests for these two antibodies are best ordered together for interpretation. These antibodies are part of ARUP’s Autoimmune Neurologic Disease Reflexive Panel (3003058) and Voltage-Gated Calcium Channel (VGCC) Antibody Panel (3002046) tests.
- Antineuronal nuclear antibody type 3 and Purkinje cell cytoplasmic antibody type 2 likely represent <0.01% of disease cases; testing for these antibodies is not offered at ARUP Laboratories.
- The clinical impacts of some antibodies, such as alpha internexin, GFAP, IgLon5, mGluR1, NIF heavy chain, and NIF light chain, are still being researched. Testing for these antibodies is not currently available at ARUP Laboratories.
Panels Offered by ARUP:
Panel Test Code |
Panel Name |
---|---|
3004070 | Autoimmune Neurologic Disease Reflexive Panel, Seruma |
3001431 | Autoimmune Encephalitis Extended Panel, Seruma |
3002929 | Paraneoplastic Reflexive Panela |
2007961 | PCCA/ANNA by IFA with Reflex to Titer and Immunoblot |
3002887 | Autoimmune Neurologic Disease Reflexive Panel, CSFb |
3002787 | Autoimmune Encephalitis Reflexive Panel, CSFb |
3004517 | Paraneoplastic Reflexive Panel, CSF |
2010841 | Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot, CSF |
3001283 | Autoimmune CNS Demyelinating Disease Reflexive Panel |
aFor additional information about components, see the ARUP PNS and Related Disorders Panel Testing Serum Antibodies table. bFor additional information about components, see the ARUP PNS Panel Testing CSF Antibodies table. |
The ARUP Autoimmune Neurology Panel Components Table provides a comprehensive overview of the antibody components of these panels.
Additional Resources
In addition to comprehensive test offerings, ARUP offers a variety of free content to assist you in test selection:
- ARUP Consult topic: Paraneoplastic Neurologic Syndromes and Associated Disorders
- ARUP Consult topic: Autoimmune Neuropathies - Neuropathic Disease
- Paraneoplastic Neurologic Syndromes Testing Algorithm - Serum
- Paraneoplastic Neurologic Syndromes Testing Algorithm - CSF
- ARUP Autoimmune Neurology Panel Components Table