The Institute for Clinical and Experimental Research® is focused on the development of new diagnostic assays in a wide range of disciplines. Researchers at the institute regularly publish in respected, peer-reviewed journals, give presentations at national and international organizations, author books and book chapters, and develop new tests.

There are 183 total entries for the year 2010.

Holden JA, Willmore-Payne C, Layfield LJ. Gastrointestinal stromal tumors: A guide to the diagnosis. Surgical Pathology Clinics 2010; 3(2): 241–276.

Jaskowski TD, Hill HR, Russo KP, Lakos G, Szekanecz Z, Teodorescu M. Relationship Between Rheumatoid Factor Isotypes and IgG Anti-Cyclic Citrullinated Peptide Antibodies. Journal of Rheumatology 2010;1;37(8):1582–8.

Rodgers GM, Kraiss LW. Severe post-operative immune-mediated coagulopathy associated with bovine thrombin exposure. Pharmacotherapy 2010;30 (8): 863–863.

Rodgers GM, Kraiss LW. Severe post-operative immune-mediated coagulopathy associated with bovine thrombin exposure. Pharmacotherapy 2010;30:319e–324e.

Straseski JA, Clarke W, Sokoll LA. Application of point-of-care mMeasurement of creatinine. Check sample clinical chemistry 1006-CME/CMLE. ASCP Check Sample 2010;50(6):69–82.

Wu AHB, Lewandrowski K, Gronowski AM, Grenache DG, Sokoll L, Magnani B. Antiquated tests within the clinical pathology laboratory. American Journal of Managed Car 2010;19(9):e220–7.

Xu X, Bromme EH, Rashidi HH, South ST, Dell' Aquila ML, Wang HU. CD-20 positive T-cell large granular lymphocytic leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma. International Journal of Clinical and Experimental Pathology 2010;3(8):798–807.

Salama ME, Rajan Mariappan M, Inamdar K, Tripp SR, Perkins SL. The value of CD23 expression as an additional marker in distinguishing mediastinal (thymic) large B-cell lymphoma from Hodgkin lymphoma. International Journal of Surgical Pathology 2010;18(2):121–8.

Rondina MT, Wheeler M, Rodgers GM, Draper L, Pendleton RC. Weight-based dosing of enoxaparin for VTE prophylaxis in morbidly obese, medically-Ill patients. Thrombosis Research 2010;125(3):220–3.

She RC, Hammond EH. Utility of immunofluorescence and electron microscopy in endomyocardial biopsies from patients with unexplained heart failure. Cardiovascular Pathology 2010;e99–e105.

Kushnir MM, Rockwood AL, Bergquist J. Liquid chromatography-tandem mass spectrometry applications in endocrinology. Mass Spectrometry Reviews 2010;29(3):480–502.

Guan Y, Ramasamy Reddy K, Zhu Q, Li Y, Lee K, Weerasinghe P, Prchal J, Semenza GL, Jing N. G-rich Oligonucleotides Inhibit HIF-1alpha and HIF-2alpha and Block Tumor Growth. Molecular therapy: The Journal of the American Society of Gene Therapy 2010;18(1):188–97.

Layfield LJ, Dodd LG, Hirschowitz S, Crabtree SN. Fine-needle aspiration of primary osseous lesions: A cost effectiveness study. Diagnostic Cytopathology 2010;38(4):239–243.

Huang X, Pierce LJ, Chen GL, Chang KT, Spangrude GJ, Prchal JT. Erythropoietin receptor signaling regulates both erythropoiesis and megakaryopoiesis in vivo. Blood Cells, Molecules & Diseases 2010;44(1):1–6.

Whittington J, Fantz CR, Gronowski AM, McCudden C, Mullins R, Sokoll L, Wiley C, Wilson A, Grenache DG. The analytical specificity of human chorionic gonadotropin assays determined using WHO International Reference Reagents. Clinica Chimica Acta 2010;411(1–2):81–5.

Vaughn CP, Wilson AR, Samowitz WS. Quantitative evaluation of CpG island methylation in hyperplastic polyps. Modern Pathology 2010;23(1):151–6.

Best DH, Butz GM, Coleman WB. Cytokine-dependent activation of small hepatocyte-like progenitor cells in retrorsine-induced rat liver injury. Experimental and Molecular Pathology 2010;88(1):7–14.

Nelson M, Perkins SL, Dave BJ, Coccia PF, Bridge JA, Lyden ER, Heerema NA, Lones MA, Harrison L, Cairo MS, Sanger WG. An increased frequency of 13q deletions detected by fluorescence in situ hybridization and its impact on survival in children and adolescents with Burkitt lymphoma: results from the Children's Oncology Group study CCG-5961. British Journal of Haematology 2010;148(4):600–10.

McCudden CR, Sharpless JL, Grenache DG. Comparison of multiple methods for identification of hyperprolactinemia in the presence of macroprolactin. Clinica Chimica Acta 2010;411(3–4):155–60.

Cloud JL, Hanson KE, Bauman SK, Ashwood ER. Extent of interlaboratory discrepancies for polyclonal Histoplasma antigen enzyme immunoassay cannot be determined without a large split-sample study. Diagnostic Microbiology and Infectious Diseases 2010;66(2):233–4.

Chou LS, Liu CS, Boese B, Zhang X, Mao R. DNA Sequence Capture and Enrichment by Microarray Followed by Next-Generation Sequencing for Targeted Resequencing: Neurofibromatosis Type 1 Gene as a Model. Clinical Chemistry 2010;56(1):62–72.

Pickering JW, Larson MT, Martins TB, Copple SS, Hill HR. Elimination of false-positive results in a luminex assay for pneumococcal antibodies. Clinical and Vaccine Immunology 2010;17(1):185–9.

Welch RJ, Litwin CM. Evaluation of two immunoblot assays and a Western blot assay for the detection of antisyphilis immunoglobulin g antibodies. Clinical and Vaccine Immunology 2010;17(1):183–4.

Caron JE, La Pine TR, Augustine NH, Martins TB, Hill HR. Multiplex Analysis of Toll-Like Receptor-Stimulated Neonatal Cytokine Response. Neonatology 2010;97(3):266–273.

Crockett DK, Kushnir MM, Phillips JD, Rockwood AL. Time-of-flight mass spectrometry analysis of the ferroportin-hepcidin binding domain complex for accurate mass confirmation of bioactive hepcidin 25. Clinica Chimica Acta 2010;411(5–6):453–5.

Hammoud A, Carrell DT, Meikle AW, Xin Y, Hunt SC, Adams TD, Gibson M. An aromatase polymorphism modulates the relationship between weight and estradiol levels in obese men. Fertility and Sterility 2010;94(5):1734–1738.

Chihara S, Smith G, Petti CA. Carbapenem susceptibility patterns for clinical isolates of Mycobacterium abscessus determined by the Etest method. Journal of Clinical Microbiology 2010;48(2):579–80.

Voelkerding KV, Lyon E. Digital Fetal Aneuploidy Diagnosis by Next-Generation Sequencing. Clinical Chemistry 2010;56(3):336–8.

Wallander M, Layfield LJ, Jarboe E, Emerson L, Liu T, Thaker H, Holden J, Tripp S. Follicular Variant of Papillary Carcinoma: Reproducibility of Histologic Diagnosis and Utility of HBME-1 Immunohistochemistry and BRAF Mutational Analysis as Diagnostic Adjuncts. Applied Immunohistochemistry & Molecular Morphology 2010;18(3):231–5.

She RC, Hymas WC, Taggart EW, Petti CA, Hillyard D. Performance of Enterovirus Genotyping Targeting the VP1 and VP2 Regions on Non-typeable Isolates and Patient Specimens. Journal of Clinical Microbiology 2010;165(1):46–50.

Svensson AM, Chou LS, Miller CE, Robles JA, Swensen JJ, Voelkerding KV, Mao R, Lyon E. Detection of large rearrangements in the cystic fibrosis transmembrane conductance regulator gene by multiplex ligation-dependent probe amplification assay when sequencing fails to detect two disease-causing mutations. Genetic Testing and Molecular Biomarkers 2010;14(2):171–4.

Wyness SP, La'ulu SL, Hunsaker JJ, Tebo AE, Roberts WL. Performance characteristics of three random access cyclic citrullinated peptide antibody assays. Clinica Chimica Acta 2010;411(5–6):428–32.

Hill HR. Group A Streptococcal Carrier Versus Acute Infection: The Continuing Dilemma. Clinical Infectious Diseases 2010;50(4):491–2.

Skripenova S, Layfield LJ. Initial margin status for invasive ductal carcinoma of the breast and subsequent identification of carcinoma in reexcision specimens. Archives of Pathology & Laboratory Medicine 2010;134(1):109–14.

Marin SJ, McMillin GA. LC-MS/MS Analysis of 13 Benzodiazepines and Metabolites in Urine, Serum, Plasma, and Meconium. Methods in Molecular Biology 2010;603:89–105.

Kushnir MM, Rockwood AL, Yue B, Meikle AW. High Sensitivity Measurement of Estrone and Estradiol in Serum and Plasma Using LC-MS/MS. Methods in Molecular Biology 2010;603:219–28.

Yue B, Kushnir MM, Urry FM, Rockwood AL. Quantitation of Nicotine, Its Metabolites, and Other Related Alkaloids in Urine, Serum, and Plasma Using LC-MS-MS. Methods in Molecular Biology 2010;603:389–98.

Sundberg SO, Wittwer CT, Gao C, Gale BK. Spinning disk platform for microfluidic digital polymerase chain reaction. Analytical Chemistry 2010;82(4):1546–50.

Erali M, Wittwer CT. High Resolution Melting Analysis for Gene Scanning. Methods 2010;50(4):250–261.

Chen AT, Prchal JT. JAK2 kinase inhibitors and myeloproliferative disorders. Current Opinion in Hematology 2010;17(2):110–6.

Kumánovics A, Wittwer CT, Pryor RJ, Augustine NH, Leppert MF, Carey JC, Ochs HD, Wedgwood RJ, Faville RJ Jr, Quie PG, Hill HR. Rapid molecular analysis of the STAT3 gene in job syndrome of hyper-IgE and recurrent infectious diseases. Journal of Molecular Diagnostics 2010;12(2):213–9.

Smith GD, Bentz JS. FISHing to detect urinary and other cancers: validation of an imaging system to aid in interpretation. Cancer Cytopathology 2010;118(1):56–64.

Szankasi P, Bahler DW. Clinical Laboratory Analysis of Immunoglobulin Heavy Chain Variable Region Genes for Chronic Lymphocytic Leukemia Prognosis. Journal of Molecular Diagnostics 2010;12(2):244–9.

Brothman AR, Persons DL, Shaffer LG. Nomenclature Evolution: Changes in the ISCN from the 2005 to the 2009 Edition. Cytogenetic and Genome Research 2010;127(1):1–4.

Merrill RM, Kelley TA, Cox E, Layman AB, Layton BJ, Lindsay R. Factors and barriers influencing influenza vaccination among students at Brigham Young University. Medical Science Monitor 2010;16(2):PH29–34.

Thompson OM, Beresford SA, Kirk EA, Bronner MP, Vaughan TL. Serum leptin and adiponectin levels and risk of Barrett's esophagus and intestinal metaplasia of the gastroesophageal junction. Obesity 2010;18(11):2204–11.

Hill HR, Wittwer CT. The evaluation of dihydrorhodamine 123 assay in chronic granulomatous disease. Pediatric Infectious Disease Journal 2010;29(2):191.

Teman CJ, Wilson AR, Perkins SL, Hickman K, Prchal JT, Salama ME. Quantification of fibrosis and osteosclerosis in myeloproliferative neoplasms: A computer-assisted image study. Leukemia Research 2010;34(7):871–876.

Slattery ML, Herrick J, Curtin K, Samowitz W, Wolff RK, Caan BJ, Duggan D, Potter JD, Peters U. Increased risk of colon cancer associated with a genetic polymorphism of SMAD7. Cancer Research 2010;70(4):1479–85.

Yoon D, Okhotin DV, Kim B, Okhotina Y, Okhotin DJ, Miasnikova GY, Sergueeva AI, Polyakova LA, Maslow A, Lee Y, Semenza GL, Prchal JT, Gordeuk VR. Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha. Journal of Molecular Medicine 2010;88(5):523–30.

Lu J, Grenache DG. High-throughput tissue homogenization method and tissue-based quality control materials for a clinical assay of the intestinal disaccharidases. Clinica Chimica Acta 2010;411(9–10):754–7.

Lin P, Luthra R, Nussenzveig RH, Medeiros LJ. JAK2 V617F mutation is uncommon in patients with the 3q21q26 syndrome. Human Pathology 2010;41(5):758–62.

Cloud JL, Harmsen D, Iwen PC, Dunn JJ, Hall G, Lasala PR, Hoggan K, Wilson D, Woods GL, Mellmann A. Comparison of traditional phenotypic identification methods with partial 5' 16S rRNA gene sequencing for species-level identification of nonfermenting Gram-negative bacilli. Journal of Clinical Microbiology 2010;48(4):1442–4.

Naessen T, Sjogren U, Bergquist J, Larsson M, Lind L, Kushnir M. Endogenous Steroids Measured by High Specificity LC-MS/MS and prevalent CVD in 70 year old Men and Women. Journal of Clinical Endocrinology and Metabolism 2010;95(4):1889–97.

Naessen T, Kushnir MM, Chaika A, Nosenko J, Mogilevkina I, Rockwood AL, Carlstrom K, Bergquist J, Kirilovas D. Steroid profiles in ovarian follicular fluid in women with and without polycystic ovary syndrome, analyzed by liquid chromatography-tandem mass spectrometry. Fertility and Sterility 2010;94(6):2228–33.

Little RR, Rohlfing CL, Hanson SE, Roberts WL. Effects of hemoglobin C and S traits on Tosoh G8 and Siemens Advia HbA1c assays. Clinica Chimica Acta 2010;411(9–10).

Blanchard N, Kanaseki T, Escobar H, Delebecque F, Nagarajan NA, Reyes-Vargas E, Crockett DK, Raulet DH, Delgado JC, Shastri N. Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing Defines the Composition and Structure of MHC Class I Peptide Repertoire in Normal and Virus-Infected Cells. Journal of Immunology 2010;184(6):3033–42.

Bailey NG, South ST, Hummel M, Wenger SL. Case Report: Cytogenetic and Molecular Analysis of Proximal Interstitial Deletion of 4p, Review of the Literature and Comparison with Wolf-Hirschhorn Syndrome. Journal of the Association of Genetic Technologists 2010;36(1):5–10.

Bender JM, Cox CM, Mottice S, She RC, Korgenski K, Daly JA, Pavia AT. Invasive Haemophilus influenzae disease in Utah children: an 11-year population-based study in the era of conjugate vaccine. Clinical Infectious Diseases 2010;50(7):e41–6.

Muram-Zborovski TM, Stevenson DA, Viskochil DH, Dries DC, Wilson AR, Mao R. SPRED1 Mutations in a Neurofibromatosis Clinic. Journal of Child Neurlogy 2010;25(10):1203–9.

Smock KJ, Crist RA, Hansen SJ, Rodgers GM, Lehman CM. Discard tubes are not necessary when drawing samples for specialized coagulation testing. Blood Coagulation and Fibrinolysis 2010;21(3):279–82.

Penmetsa GK, Rodgers GM, Smock KJ. Avoiding errors in the laboratory evaluation of potent lupus anticoagulants. American Journal of Hematology 2010;85(4):272–4.

Bradley KT, Arber DA, Brown MS, Chang CC, Coupland SE, de Baca ME, Ellis DW, Foucar K, Hsi ED, Jaffe ES, Lill MC, McClure SP, Medeiros LJ, Perkins SL. Protocol for the examination of specimens from patients with hematopoietic neoplasms of the ocular adnexa. Archives of Pathology & Laboratory Medicine 2010;134(3):336–40.

Vaughn CP, Robles J, Swensen JJ, Miller CE, Lyon E, Mao R, Bayrak-Toydemir P, Samowitz WS. Clinical Analysis of PMS2: Mutation Detection and Avoidance of Pseudogenes. Human Mutation 2010;31(5):588–93.

Breaud AR, Harlan R, Di Bussolo JM, McMillin GA, Clarke W. A rapid and fully-automated method for the quantitation of tricyclic antidepressants in serum using turbulent-flow liquid chromatography-tandem mass spectrometry. Clinica Chimica Acta 2010;411(11–12):825–32.

Montgomery JL, Sanford LN, Wittwer CT. High-resolution DNA melting analysis in clinical research and diagnostics. Expert Review of Molecular Diagnostics 2010;10(2):219–40.

Bruchova-Votavova H, Yoon D, Prchal JT. miR-451 enhances erythroid differentiation in K562 cells. Leukemia & Lymphoma 2010;51(4):686–93.

Layfield LJ, Jarboe EA. Cytopathology of the pancreas: neoplastic and nonneoplastic entities. Annals of Diagnostic Pathology 2010;14(2):140–151.

Pounder JI, Anderson CM, Voelkerding KV, Salfinger M, Dormandy J, Somoskovi A, Heifets L, Graham JJ, Storts DR, Petti CA. Mycobacterium tuberculosis complex differentiation by genomic deletion patterns with multiplex polymerase chain reaction and melting analysis. Diagnostic Microbiology and Infectious Disease 2010;67(1):101–5.

Hill HR, Augustine NH, Pryor RJ, Reed GH, Bagnato JD, Tebo AE, Bender JM, Pasi BM, Chinen J, Hanson IC, de Boer M, Roos D, Wittwer CT. Rapid genetic analysis of x-linked chronic granulomatous disease by high-resolution melting. Journal of Molecular Diagnostics 2010;12(3):368–76.

Smock KJ, Rodgers GM. Laboratory evaluation of aspirin responsiveness. American Journal of Hematology 2010;85(5):358–60.

White AT, Light AR, Hughen RW, Bateman L, Martins TB, Hill HR, Light KC. Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome. Psychophysiology 2010;47(4):615–24.

Zhou L, Palais RA, Smith GD, Anderson D, Rowe LR, Wittwer CT. Enrichment and Detection of Rare Alleles by Means of Snapback Primers and Rapid-Cycle PCR. Clinical Chemistry 2010;56(5):814–22.

McCloskey LJ, Christner P, Jacobs-Kosmin D, Jaskowski TD, Hill HR, Lakos G, Teodorescu M. Myth and reality: practical test system for the measurement of anti-DNA antibodies in the diagnosis of systemic lupus erythematosus (SLE). Journal of Clinical Laboratory Analysis 2010;24(2):77–84.

Haven TR, Astill ME, Pasi BM, Carper JB, Wu L, Tebo AE, Hill HR. An Algorithm for Acetylcholine Receptor Antibody Testing in Patients with Suspected Myasthenia gravis. Clinical Chemistry 2010;56(6):1028–9.

Hymas WC, Mills A, Ferguson S, Langer J, She RC, Mahoney W, Hillyard DR. Development of a multiplex real-time RT-PCR assay for detection of Influenza A, Influenza B, RSV and typing of the 2009-H1N1 influenza virus. Journal of Virological Methods 2010;167(2):113–118.

Beals TC, Nickisch F, Teman C, Florell SR, Layfield LJ. Chondroid syringoma: case report of a highly unusual foot tumor. Foot & Ankle International 2010;31(4):333–5.

Singh IR, Gorzynski JE, Drobysheva D, Bassit L, Schinazi RF. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS ONE 2010; 5(4): e9948.

Slattery ML, Curtin K, Wolff RK, Herrick JS, Caan BJ, Samowitz W. Diet, physical activity, and body size associations with rectal tumor mutations and epigenetic changes. Cancer Causes & Control 2010;21(8):1237–45.

Owen WE, Rawlins ML, Roberts WL. Selected Performance Characteristics of the Roche Elecsys® Testosterone II Assay on the Modular Analytics E 170 Analyzer. Clinica Chimica Acta 2010;411(15–16):1073–9.

McMillin GA, Melis R, Wilson A, Strong MB, Wanner NA, Vinik RG, Peters CL, Pendleton RC. Gene-based warfarin dosing compared with standard of care practices in an orthopedic surgery population: a prospective, parallel cohort study. Therapeutic Drug Monitoring 2010;32(3):338–45.

McMillin GA, Juenke JM, Tso G, Dasgupta A. Estimation of carbamazepine and carbamazepine-10,11-epoxide concentrations in plasma using mathematical equations generated with two carbamazepine immunoassays. American Journal of Clinical Pathology 2010;133(5):728–36.

La'ulu SL, Roberts WL. Performance Characteristics of Five Cardiac Troponin I Assays. Clinica Chimica Acta 2010;411(15–16):1095–101.

Wooderchak W, Gedge F, McDonald M, Krautscheid P, Wang X, Malkiewicz J, Bukjiok CJ, Lewis T, Bayrak-Toydemir P. Hereditary hemorrhagic telangiectasia: two distinct ENG deletions in one family. Journal of Medical Genetics 2010;78(5):484–9.

Bentley MJ, Lehman CM, Blaylock RC, Wilson AR, Rodgers GM. The utility of patient characteristics in predicting severe ADAMTS13 deficiency and response to plasma exchange. Transfusion 2010;50(8):1654–64.

Lyon E, Laver T, Yu P, Jama M, Young K, Zoccoli M, Marlowe N. A simple, high-throughput assay for Fragile X expanded alleles using triple repeat primed PCR and capillary electrophoresis. Journal of Molecular Diagnostics 2010;12(4):505–11.

Slattery ML, Wolff RK, Herrick JS, Caan BJ, Samowitz W. Calcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors. Nutrition and Cancer 2010;62(4):436–42.

Roberts WL, Rockwood AL, Bunker AM, Kushnir MM, Meikle AW. Limitations of the Hoffman approach to determine pediatric reference intervals for two steroids. Clinical Biochemistry 2010;43(10–11):933–4; author reply 935.

Smith GD, Riding M, Bentz JS. Integrating a FISH Imaging System into the cytology laboratory: A new role for cytology professionals. CytoJournal 2010;0.29375.

Li M, Petteys BJ, McClure JM, Valsakumar V, Bekiranov S, Frank EL, Smith JS. Thiamine biosynthesis in Saccharomyces cerevisiae is regulated by the NAD+-dependent histone deacetylase Hst1. Molecular and Cellular Biology 2010;30(13):3329–41.

Jaskowski TD, Donaldson MR, Hull CM, Wilson AR, Hill HR, Zone JJ, Book LS. Novel screening assay performance in pediatric celiac disease and adult dermatitis herpetiformis. Journal of Pediatric Gastroenterology and Nutrition 2010;51(1):19–23.

Sandrock RW, Wheatley W, Levinthal C, Lawson J, Hashimoto B, Rao M, Campanelli JT. Isolation, characterization and preclinical development of human glial-restricted progenitor cells for treatment of neurological disorders. Regenerative Medicine 2010;5(3):381–94.

Miller DT, Adam MP, Aradhya S, Biesecker LG, Brothman AR, Carter NP, Church DM, Crolla JA, Eichler EE, Epstein CJ, Faucett WA, Feuk L, Friedman JM, Ha. Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. American Journal of Human Genetics 2010;86(5):749–64.

Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R. Genetic Evidence for High-Altitude Adaptation in Tibet. Science 2010;329(5987):72–5.

Chen R, Crispin DA, Pan S, Hawley S, McIntosh MW, May D, Anton-Culver H, Ziogas A, Bronner MP, Brentnall TA. Pilot study of blood biomarker candidates for detection of pancreatic cancer. Pancreas 2010;39(7):981–8.

Mao R, Chou LS. Methylation analysis by restriction endonuclease digestion and real-time PCR. Clinical Chemistry 2010;56(7):1050–2.

Folkins AK, Nevadunsky NS, Saleemuddin A, Jarboe EA, Muto MG, Feltmate CM, Crum CP, Hirsch MS. Evaluation of vascular space involvement in endometrial adenocarcinomas: laparoscopic vs abdominal hysterectomies. Modern Pathology 2010;23(8):1073–9.

Slev PR, Bunker AM, Owen WE, Roberts WL. Pediatric reference intervals for random urine calcium, phosphorus and total protein. Pediatric Nephrology 2010;25(9):1707–10.

Miles RR, Afify Z, Yaish H, Perkins SL. CD56-negative extranodal nasal type NK/T-cell lymphoma. Pediatric Blood & Cancer 2010;55(1):186–9.

Welch RJ, Litwin CM. A comparison of Brucella IgG and IgM ELISA assays with agglutination methodology. Journal of Clinical Laboratory Analysis 2010;24(3):160–2.

Kushnir MM, Blamires T, Rockwood AL, Roberts WL, Yue B, Erdogan E, Bunker AM, Meikle AW. Liquid chromatography-tandem mass spectrometry assay for androstenedione, dehydroepiandrosterone, and testosterone with pediatric and adult reference intervals. Clinical Chemistry 2010;56(7):1138–47.

Nouraie M, Reading NS, Campbell A, Minniti CP, Rana SR, Luchtman-Jones L, Kato GJ, Gladwin MT, Castro OL, Prchal JT, Gordeuk VR. Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia. British Journal of Haematology 2010;150(2):218–25.

Kelley TW, Parker CJ. CD4 (+)CD25 (+)Foxp3 (+) regulatory T cells and hematologic malignancies. Frontiers in Bioscience 2010;2:980–92.

Jaskowski TD, Hill HR, Russo KL, Lakos G, Szekanecz Z, Teodorescu M. Relationship between rheumatoid factor isotypes and IgG anti-cyclic citrullinated peptide antibodies. Journal of Rheumatology 2010;37(8):1582–8.

Ray JA, Meikle AW. D-light: vitamin D and good health. Medical Laboratory Observer 2010;42(5):32, 34–8.

Neklason DW, Tuohy TM, Stevens J, Otterud B, Baird L, Kerber RA, Samowitz WS, Kuwada SK, Leppert MF, Burt RW. Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer. Journal of Molecular Genetics 2010;47(10):692–9.

Hussong JW, Arber DA, Bradley KT, Brown MS, Chang CC, de Baca ME, Ellis DW, Foucar K, Hsi ED, Jaffe ES, Lill M, McClure SP, Medeiros LJ, Perkins SL; M. Protocol for the examination of specimens from patients with non-Hodgkin lymphoma/lymphoid neoplasms. Archives of Pathology & Laboratory Medicine 2010;134(6):e40–7.

Whittington JE, La’ulu SL, Hunsaker JJH, Roberts WL. The Osmolal Gap: What has changed? Clinical Chemistry 2010;56(8):1353–5.

Borowitz MJ, Craig FE, Digiuseppe JA, Illingworth AJ, Rosse W, Sutherland DR, Wittwer CT, Richards SJ; Clinical Cytometry Society. Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry. Cytometry, Part B 2010;78(4):211–30.

She RC, Polage CR, Caram LB, Taggart EW, Hymas WC, Woods CW, Schmader K, Petti CA. Performance of diagnostic tests to detect respiratory viruses in older adults. Diagnostic Microbiology and Infectious Diseases 2010;67(3):246–50.

Kushnir M, Ray JA, Rockwood AL, Roberts WL, La'ulu SL, Whittington J, Meikle AW. Rapid Analysis of 25OH Vitamins D2 and D3 by LC-MS/MS and Association of Vitamin D and Parathyroid Hormone Concentrations in Healthy Adults. American Journal of Clinical Pathology 2010;134(1):148–56.

Pavlov IY, Wilson AR, Delgado JC. Resampling approach for determination of the method for reference interval calculation in clinical laboratory practice. Clinical and Vaccine Immunology 2010;17(8):1217–22.

Carlson JW, Jarboe EA, Kindelberger D, Nucci MR, Hirsch MS, Crum CP. Serous tubal intraepithelial carcinoma: diagnostic reproducibility and its implications. International Journal of Gynecological Pathology 2010;29(4):310–4.

Pyne MT, Brown KL, Hillyard DR. Evaluation of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 test and identification of rare polymorphisms potentially affecting assay performance. Journal of Clinical Microbiology 2010;48(8):2852–8.

Hussain S, Foreman O, Perkins SL, Witzig TE, Miles RR, van Deursen J, Galardy PJ. The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling. Leukemia 2010;24(9):1641–55.

Crockett DK, Pont-Kingdon G, Gedge F, Sumner K, Seamons R, Lyon E. The Alport syndrome COL4A5 variant database. Human Mutation 2010;31(8):E1652–7.

Tefferi A, Smock KJ, Divgi AB. Polycythemia vera-associated acquired von Willebrand syndrome despite near-normal platelet count. American Journal of Hematology 2010;85(7):545.

Wittwer CT. Making DNA Melting Useful. Clinical Chemistry 2010;56(9):1500–1.

Johnson-Davis KL, McMillin GA, Juenke JM, Ford CD, Petersen FB. Which dose of busulfan is best? Clinical Chemistry 2010;56(7):1061–4.

Jarboe EA, Venkat P, Hirsch MS, Cibas ES, Crum CP, Garner EI. A weakly positive human papillomavirus Hybrid Capture II result correlates with a significantly lower risk of cervical intraepithelial neoplasia 2,3 after atypical squamous cells of undetermined significance cytology. Journal of Lower Genital Tract Disease 2010;14(3):174–8.

Dames S, Durtschi J, Geiersbach K, Stephens J, Voelkerding KV. Comparison of the Illumina Genome Analyzer and Roche 454 GS FLX for resequencing of hypertrophic cardiomyopathy-associated genes. Journal of Biomolecular Techniques 2010;21(2):73–80.

Swensen JJ, Agarwal AM, Esquilin JM, Swierczek S, Perumbeti A, Hussey D, Joiner CH, Pont-Kingdon G, Lyon E, Prchal JT. Sickle cell disease due to uniparental disomy in a child who inherited sickle cell trait. Blood 2010;116(15):2822–5.

South ST, Rector L, Aston E, Rowe L, Yang SP. Large clinically consequential imbalances detected at the breakpoints of apparently balanced and inherited chromosome rearrangements. Journal of Molecular Diagnostics 2010;12(5):725–9.

Erdogan E, Nelson GJ, Rockwood AL, Frank EL. Evaluation of reference intervals for methylmalonic acid in plasma/serum and urine. Clinica Chimica Acta 2010;411(21–22):1827–9.

Best DH, Coleman WB. Liver regeneration by small hepatocyte-like progenitor cells after necrotic injury by carbon tetrachloride in retrorsine-exposed rats. Experimental and Molecular Pathology 2010;89(2):92–8.

Erickson JA, Lu J, Smith JJ, Bornhorst JA, Grenache DG, Ashwood ER. Immunoassay for quantifying squamous cell carcinoma antigen in serum. Clinica Chimica Acta 2010;56(9):1496–9.

Muram-Zborovski TM, Vaughn CP, Viskochil DH, Hanson H, Mao R, Stevenson DA. NF1 exon 22 analysis of individuals with the clinical diagnosis of neurofibromatosis type 1. American Journal of Medical Genetics 2010;152A(8):1973–8.

Ardon O, Amat di San Filippo C, Salomons GS, Longo N. Creatine transporter deficiency in two half-brothers. American Journal of Medical Genetics 2010;152A(8):1979–83.

Albashir S, Bronner MP, Parsi MA, Walsh RM, Stevens T. Endoscopic ultrasound, secretin endoscopic pancreatic function test, and histology: correlation in chronic pancreatitis. American Journal of Gastroenterology 2010;105(11):2498–503.

She RC, Thurber A, Hymas WC, Stevenson J, Langer J, Litwin CM, Petti CA. Limited Utility of Culture for Mycoplasma pneumoniae and Chlamydophila pneumoniae for the Diagnosis of Respiratory Tract Infections. Journal of Clinical Microbiology 2010;48(9):3380–2.

Iroh Tam PY, Fisher MA, Miller NS. Corynebacterium falsenii bacteremia occurring in an infant on vancomycin therapy. Journal of Clinical Microbiology 2010;48(9):3440–2.

Simmon KE, Kommedal Ø, Saebo Ø, Karlsen B, Petti CA. Simultaneous sequence analysis of the 16S rRNA and rpoB genes by use of RipSeq software to identify Mycobacterium species. Journal of Clinical Microbiology 2010;48(9):3231–5.

Slattery ML, Wolff RK, Herrick JS, Curtin K, Caan BJ, Samowitz W. Alcohol consumption and rectal tumor mutations and epigenetic changes. Diseases of the Colon and Rectum 2010;53(8):1182–9.

Wilkerson MD, Yin X, Hoadley KA, Liu Y, Hayward MC, Cabanski CR, Muldrew K, Miller CR, Randell SH, Socinski MA, Parsons AM, Funkhouser WK, Lee CB, Rob. Lung Squamous Cell Carcinoma mRNA Expression Subtypes Are Reproducible, Clinically Important, and Correspond to Normal Cell Types. Clinical Cancer Research 2010;16(19):4864–75.

Allred AF, Wu G, Wulan T, Fischer KF, Holbrook MR, Tesh RB, Wang D. VIPR: A probabilistic algorithm for analysis of microbial detection microarrays. BMC Bioinformatics 2010;11:384.

Drakos SG, Kfoury AG, Hammond EH, Reid BB, Revelo MP, Rasmusson BY, Whitehead KJ, Salama ME, Selzman CH, Stehlik J, Clayson SE, Bristow MR, Renlund DG. Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart. Journal of the American College of Cardiology 2010;56(5):382–91.

Lu J, Snider JV, Grenache DG. Establishment of reference intervals for soluble ST2 from a United States population. Clinica Chimica Acta 2010;411:21–22.

Harlan R, Clarke W, Di Bussolo JM, Kozak M, Straseski J, Meany DL. An automated turbulent flow liquid chromatography-isotope dilution mass spectrometry (LC-IDMS) method for quantitation of serum creatinine. Clinica Chimica Acta 2010;411(21–22):1728–34.

Straseski JA, Stolbach A, Clarke W. Opiate-positive immunoassay screen in a pediatric patient. Clinical Chemistry 2010;56(8):1220–3.

Clayton AC, Bentz JS, Wasserman PG, Schwartz MR, Souers RJ, Chmara BA, Laucirica R, Clary KM, Moriarty AT; College of American Pathologists Cytopathol. Comparison of ThinPrep preparations to other preparation types in gastrointestinal cytology: observations from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Archives of Pathology & Laboratory Medicine 2010;134(8):1116–20.

She RC, Taggart EW, Petti CA. Comparison of 10 indirect fluorescent antibodies to detect and type influenza A specimens. Archives of Pathology & Laboratory Medicine 2010;134(8):1177–80.

Grenache DG, Wilson AR, Gross GA, Gronowski AM. Clinical and laboratory trends in fetal lung maturity testing. Clinica Chimica Acta 2010;411(21–22):1746–9.

Toydemir R, Rowe L, Hibbard M, Salama M, Shetty S. Cytogenetic and molecular characterization of double inversion 3 associated with a cryptic BCR-ABL1 rearrangement and additional genetic changes. Cancer Genetics and Cytogenetics 2010;201(2):81–87.

Perou CM, Parker JS, Prat A, Ellis MJ, Bernard PS. Clinical implementation of the intrinsic subtypes of breast cancer. The Lancet Oncology 2010;11(8):718–9.

Perrotta S, Cucciolla V, Ferraro M, Ronzoni L, Tramontano A, Rossi F, Scudieri AC, Borriello A, Roberti D, Nobili B, Cappellini MD, Oliva A, Amendola . EPO Receptor Gain-of-Function Causes Hereditary Polycythemia, Alters CD34 Cell Differentiation and Increases Circulating Endothelial Precursors. PLoS ONE 2010;5(8). pii: e12015.

Zhou L, Collins DC, Lee ED, Rockwood AL, Lee ML. Erratum to: Mechanical ion gate for electrospray-ionization ion-mobility spectrometry. Analytical and Bioanalytical Chemistry 2010;398(4):1833.

Webber NP, Sharma S, Grossmann AH, Shaaban A, Jones KB, Layfield LJ, Randall RL. Metastatic Pancreatic Adenocarcinoma Presenting as a Large Pelvic Mass Mimicking Primary Osteogenic Sarcoma: A Series of Two Patient Cases. Journal of Clinical Oncology 2010;28(29):e545–9.

Fakhouri TH, Stevenson J, Chisholm AD, Mango SE. Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA. PLoS Genetics 2010;6(8).

Lockwood CM, Crompton JC, Riley JK, Landeros K, Dietzen DJ, Grenache DG, Gronowski AM. Validation of lamellar body counts using three hematology analyzers. American Journal of Clinical Pathology 2010;134(3):420–8.

Layfield LJ, Anderson GM. Specimen labeling errors in surgical pathology: an 18-month experience. American Journal of Clinical Pathology 2010;134(3):466–70.

Roos D, Kuhns DB, Maddalena A, Roesler J, Lopez JA, Ariga T, Avcin T, de Boer M, Bustamante J, Condino-Neto A, Di Matteo G, He J, Hill HR, Holland SM,. Hematologically important mutations: X-linked chronic granulomatous disease (third update). Blood Cells, Molecules & Diseases 2010;45(3):246–65.

Syed SS, Aderinboye O, Hanson KE, Spitzer ED. Acute cervical lymphadenitis caused by Mycobacterium florentinum. Emerging Infectious Diseases 2010;16(9):1486–7.

Ellis NM, Kurahara DK, Vohra H, Mascaro-Blanco A, Erdem G, Adderson EE, Veasy LG, Stoner JA, Tam E, Hill HR, Yamaga K, Cunningham MW. Priming the immune system for heart disease: a perspective on group A streptococci. Journal of Infectious Diseases 2010;202(7):1059–67.

Bronner MP, Skacel M, Crispin DA, Hoff PD, Emond MJ, Lai LA, Tubbs RR, O'Sullivan JN, Rabinovitch PS, Brentnall TA.. Array-based comparative genomic hybridization in ulcerative colitis neoplasia: single non-dysplastic biopsies distinguish progressors from non-progressors. Modern Pathology 2010;23(12):1624–33.

Voelkerding KV, Dames S, Durtschi JD. Next generation sequencing for clinical diagnostics-principles and application to targeted resequencing for hypertrophic cardiomyopathy: a paper from the 2009 William Beaumont Hospital Symposium on Molecular Pathology. Journal of Molecular Diagnostics 2010;12(5):539–51.

Margraf RL, Durtschi JD, Dames S, Pattison DC, Stephens JE, Mao R, Voelkerding KV. Multi-sample pooling and illumina genome analyzer sequencing methods to determine gene sequence variation for database development. Human Mutation 2010;21(3):126–40.

Schimke LF, Sawalle-Belohradsky J, Roesler J, Wollenberg A, Rack A, Borte M, Rieber N, Cremer R, Maass E, Dopfer R, Reichenbach J, Wahn V, Hoenig M, J. Diagnostic approach to the hyper-IgE syndromes: Immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis. Journal of Allergy and Clinical Immunology 2010;126(3):611–7.e1.

Salek J, Byrne J, Box T, Longo N, Sussman N. Recurrent liver failure in a 25-year-old female. Liver Transplantation 2010;16(9):1049–53.

Zhang J, Juedes N, Narayan VM, Yue B, Rockwood AL, Palma NL, Patel JM. A cellular model to mimic exhaled cigarette smokeinduced lung microvascular endothelial cell injury and death. International Journal of Clinical and Experimental Medicine 2010;3(3):223–32.

Dufek EJ, Ehlert B, Granger MC, Sandrock TM, Legge SL, Herrmann MG, Meikle AW, Porter MD. Competitive surface-enhanced Raman scattering assay for the 1,25-dihydroxy metabolite of vitamin D(3). Analyst 2010;135(11):2811–7.

Couturier BA, Bender JM, Schwarz MA, Pavia AT, Hanson KE, She RC. Oseltamivir-resistant influenza A 2009 H1N1 virus in immunocompromised patients. Influenza and Other Respiratory Viruses 2010;4(4):199–204.

Nielsen TO, Parker JS, Leung S, Voduc KD, Ebbert M, Vickery TL, Davies SR, Snider JE, Stijleman IJ, Reed J, Cheang MC, Mardis ER, Perou CM, Bernard PS. A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor positive breast cancer. Clinical Cancer Research 2010;16(21):5222–5232.

Jahn JE, Best DH, Coleman WB. Exogenous expression of synaptotagmin XIII suppresses the neoplastic phenotype of a rat liver tumor cell line through molecular pathways related to mesenchymal to epithelial transition. Experimental and Molecular Pathology 2010;89(3):209–16.

Liew M, Wittwer CT, Voelkerding KV. Nucleotide extension genotyping by high resolution melting. Journal of Molecular Diagnostics 2010;12(6):731–8.

Kumánovics A, Perkins SL, Gilbert H, Cessna MH, Augustine NH, Hill HR. Diffuse Large B Cell Lymphoma in Hyper-IgE Syndrome Due To STAT3 Mutation. Journal of Clinical Immunology 2010;30(6):886–93.

Patel JL, Erickson JA, Roberts WL, Grenache DG. Performance characteristics of an automated assay for the quantitation of CYFRA 21-1 in human serum. Clinical Biochemistry 2010;43(18):1449–52.

Greene DN, Hall BJ, Grenache DG. An unlikely pregnancy. Clinical Chemistry 2010;56(10):1645–6.

She RC, Taggart EW, Ruegner R, Hymas WC, Bender JM, Weir P, Petti CA. Identifying respiratory viruses in nasal mucus from children. Pediatric Infectious Disease Journal 2010;29(10):970–2.

Hammoud AO, Griffin J, Meikle AW, Gibson M, Peterson CM, Carrell DT. Association of aromatase (TTTAn) repeat polymorphism length and the relationship between obesity and decreased sperm concentration. Human Reproduction 2010;25(12):3146–51.

Brown-Elliott BA, Wallace RJ Jr., Petti CA, Mann L, McGlasson M, Chihara S, Smith, GL, Painter P, Hail D, Wilson R, Simmon KE. Mycobacterium neoaurum and Mycobacterium bacteremicum sp. nov. as Causes of Mycobacteremia. Journal of Clinical Microbiology 2010;48(12):4377–85.

Shaheen NJ, Peery AF, Hawes RH, Rothstein RI, Spechler SJ, Galanko JA, Campbell M, Carr C, Fowler B, Walsh J, Siddiqui AA, Infantolino A, Wolfsen HCM. Quality of life following radiofrequency ablation of dysplastic Barrett's esophagus. Endoscopy 2010;42(10):790–9.

Pratt VM, Zehnbauer B, Wilson JA, Baak R, Babic N, Bettinotti M, Buller A, Butz K, Campbell M, Civalier C, El-Badry A, Farkas DH, Lyon E, Mandal S, Mc. Characterization of 107 genomic DNA reference materials for CYP2D6, CYP2C19, CYP2C9, VKORC1, and UGT1A1: a GeT-RM and Association for Molecular Pathology collaborative project. Journal of Molecular Diagnostics 2010;12(6):835–46.

Wagar EA, Mitchell MJ, Carroll KC, Beavis KG, Petti CA, Schlaberg R, Yasin B. A review of sentinel laboratory performance: identification and notification of bioterrorism agents. Archives of Pathology and Laboratory Medicine 2010;134(10):1490–503.

Sireci A, Schlaberg R, Kratz A. A method for optimizing and validating institution-specific flagging criteria for automated cell counters. Archives of Pathology and Laboratory Medicine 2010;134(10):1528–33.

Grenache DG, Greene DN, Dighe AS, Fantz CR, Hoefner D, McCudden C, Sokoll L, Wiley CL, Gronowski AM. Falsely Decreased Human Chorionic Gonadotropin (hCG) Results Due to Increased Concentrations of the Free {beta} Subunit and the {beta} Core Fragment in Quantitative hCG Assays. Clinical Chemistry 2010;56(12):1839–44.

Shi L, Wang S, Zangari M, Xu H, Cao TM, Xu C, Wu Y, Xiao F, Liu Y, Yang Y, Salama M, Li G, Tricot G, Zhan F. Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug -resistance. Oncotarget 2010;1(1):22–33.

Furtado LV, Bayrak-Toydemir P, Hulinsky B, Damjanovich K, Carey JC, Rope AF. A novel X-linked multiple congenital anomaly syndrome associated with an EBP mutation. American Journal of Medical Genetics 2010;152A(11):2838–44.

Uddin N, Williams MS, South ST. Constitutional trisomy 8 mosaicism in a healthy bone marrow donor: Confirmation of first reported donor origin trisomy 8. American Journal of Hematology 2010;85(12):974–6.

Jarboe E, Layfield LJ, Collins B. Fibromatosislike metaplastic carcinoma of the breast as a diagnostic pitfall for fine needle aspiration cytology: a case report. Acta Cytologica 2010;54(5):712–6.

Pendleton RC, Rodgers GM, Hull RD. Established venous thromboembolism therapies: heparin, low molecular weight heparins, and vitamin k antagonists, with a discussion of heparin-induced thrombocytopenia. Clinics in Chest Medicine 2010;31(4):691–706.

Layfield LJ, Cibas ES, Baloch Z. Thyroid fine needle aspiration cytology: a review of the National Cancer Institute state of the science symposium. Cytopathology 2010;21(2):75–85.

Moreno-De-Luca D; SGENE Consortium, Mulle JG; Simons Simplex Collection Genetics Consortium, Kaminsky EB, Sanders SJ; GeneSTAR, Myers SM, Adam MP, Pak. Deletion 17q12 Is a Recurrent Copy Number Variant that Confers High Risk of Autism and Schizophrenia. American Journal of Human Genetics 2010;87(5):618–30.

Johnson-Davis KL, Thompson CD, Clark CJ, McMillin GA, Lehman CM. High amphetamine/methamphetamine concentrations in urine can cause error codes on the Ortho Vitros® Fusion 5,1 FS automated chemistry analyzer. Journal of Analytical Toxicology 2010;34(9):607–8.

La'ulu SL, Roberts WL. Performance Characteristics of Six Intact Parathyroid Hormone Assays. American Journal of Clinical Pathology 2010;134(6):930–938.

Smith GD, Chadwick BE, Adler DG, Bentz JS. Comparison of ThinPrep UroCyte and cytospin slide preparations for gastrointestinal specimens: Evaluation and retrospective performance review. Diagnostic Cytopathology 2010;38(12):902–12.

Seipp MT, Herrmann M, Wittwer CT. Automated DNA extraction, quantification, dilution, and PCR preparation for genotyping by high-resolution melting. Journal of Biomolecular Techniques 2010;21(4):163–6.

Irvin WJ Jr, Orlowski RZ, Chiu WK, Carey LA, Collichio FA, Bernard PS, Stijleman IJ, Perou C, Ivanova A, Dees EC. Phase II study of bortezomib and pegylated liposomal doxorubicin in the treatment of metastatic breast cancer. Clinical Breast Cancer 2010;10(6):465–70.

Wright EL, Van Hove JL, Thomas J, Pasquali M, Mountain States Metabolic Consortium.. Mountain States Genetics Regional Collaborative Center's Metabolic Newborn Screening Long-term Follow-up Study: a collaborative multi-site approach to newborn screening outcomes research. Genetics in Medicine 2010;12(12 Suppl):S228–41.

Kronn D, Mofidi S, Braverman N, Harris K; Pasquali M, Diagnostics Guidelines Work Group. Diagnostic guidelines for newborns who screen positive in newborn screening. Genetics in Medicine 2010;12(12 Suppl):S251–5.

Shirts BH, Jackson BR. Informatics methods for laboratory evaluation of HPV ordering patterns with an example from a nationwide sample in the United States, 2003-2009. Journal of Pathology Informatics 2010;0.05972.

Jarboe EA, Mutter GL. Endometrial intraepithelial neoplasia. Seminars in Diagnostic Pathology 2010;27(4):215–25.