The Institute for Clinical and Experimental Research® is focused on the development of new diagnostic assays in a wide range of disciplines. Researchers at the institute regularly publish in respected, peer-reviewed journals, give presentations at national and international organizations, author books and book chapters, and develop new tests.

There are 92 total entries for the year 2004.

Lo SF, Doumas BT, Ashwood ER. Performance of bilirubin determinations in US laboratories--revisited. Clin Chem 2004;50(1):190–4.

Amat di San Filippo C, Longo N. Tyrosine residues affecting sodium stimulation of carnitine transport in the OCTN2 carnitine/organic cation transporter. J Biol Chem 2004;279(8):7247–53.

Rockwood AL, Van Orman JR, Dearden DV. Isotopic compositions and accurate masses of single isotopic peaks. J Am Soc Mass Spectrom 2004;15(1):12–21.

Santos AD, McIntosh JM, Hillyard DR, Cruz LJ, Olivera BM. The A-superfamily of conotoxins: structural and functional divergence. J Biol Chem 2004;279(17):17596–606.

Sebastian S, Spitzer SG, Grosso LE, Amos J, Schaefer FV, Lyon E, Wolff DJ, Hajianpour A, Taylor AK, Millson A, Stenzel TT. Multicenter characterization and validation of the intron-8 poly(T) tract (IVS8-T) status in 25 Coriell cell repository cystic fibrosis reference cell lines for cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation assays. Clin Chem 2004;50(1):251–4.

Owen WE, Roberts WL. Cross-reactivity of three recombinant insulin analogs with five commercial insulin immunoassays. Clin Chem 2004;50(1):257–9.

Liew M, Erali M, Page S, Hillyard D, Wittwer C. Hepatitis C genotyping by denaturing high-performance liquid chromatography. J Clin Microbiol 2004;42(1):158–63.

Chapman JF, Ashwood ER, Feld R, Wu AH. Evaluation of two-dimensional cytometric lamellar body counts on the ADVIA 120 hematology system for estimation of fetal lung maturation. Clin Chim Acta 2004;340(1–2):85–92.

Owen WE, Roberts WL. Performance characteristics of the IMMUNLITE 2000 erythropoietin assay. Clin Chim Acta 2004;340(1–2):213–7.

Chen Z, Hong B, Drozd-Borysiuk E, Coffin C, Albritton K. Molecular cytogenetic characterization of a case of Mullerian adenosarcoma. Cancer Genet Cytogenet 2004;148(2):129–32.

Schumacher JA, Jenson SD, Elenitoba-Johnson KS, Lim MS. Utility of linearly amplified RNA for RT-PCR detection of chromosomal translocations: validation using the t(2;5)(p23;q35) NPM-ALK chromosomal translocation. J Mol Diagn 2004;6(1):16–21.

Dent KM, Kenneson A, Palumbos JC, Maxwell S, Eichwald J, White K, Mao R, Bale JF Jr, Carey JC. Methodology of a multistate study of congenital hearing loss: preliminary data from Utah newborn screening. Am J Med Genet C Semin Med Genet 2004;125(1):28–34.

Cloud JL, Conville PS, Croft A, Harmsen D, Witebsky FG, Carroll KC. Evaluation of partial 16S ribosomal DNA sequencing for identification of nocardia species by using the MicroSeq 500 system with an expanded database. J Clin Microbiol 2004;42(2):578–84.

Malan AK, Martins TB, Hill HR, Litwin CM. Evaluations of commercial West Nile virus immunoglobulin G (IgG) and IgM enzyme immunoassays show the value of continuous validation. J Clin Microbiol 2004;42(2):727–33.

Keller C, Gibbs CN, Kelly SM, Haller JR, White KS, Coffin CM, Lemons RS. Low-grade myofibrosarcoma of the head and neck: importance of surgical therapy. J Pediatr Hematol Oncol 2004;26(2):119–20.

Crockett DK, Lin Z, Elenitoba-Johnson KS, Lim MS. Identification of NPM-ALK interacting proteins by tandem mass spectrometry. Oncogene 2004;23(15):2617–29.

Proctor KA, Rao LV, Roberts WL. Gadolinium magnetic resonance contrast agents produce analytic interference in multiple serum assays. Am J Clin Pathol 2004;121(2):282–92.

Juenke JM, Brown PI, McMillin GA, Urry FM. A rapid procedure for the monitoring of amiodarone and N-desethylamiodarone by HPLC-UV detection. J Anal Toxicol 2004;28(1):63–6.

Shutt CK, Samore M, Carroll KC. Comparison of the Denka Seiken slide agglutination method to the quellung test for serogrouping of Streptococcus pneumoniae isolates. J Clin Microbiol 2004;42(3):1274–6.

Martins TB, Pasi BM, Litwin CM, Hill HR. Heterophile antibody interference in a multiplexed fluorescent microsphere immunoassay for quantitation of cytokines in human serum. Clin Diagn Lab Immunol 2004;11(2):325–9.

Weisz JL, McMahon WM, Moore JC, Augustine NH, Bohnsack JF, Bale JF, Johnson MB, Morgan JF, Jensen J, Tani LY, Veasy LG, Hill HR. D8/17 and CD19 expression on lymphocytes of patients with acute rheumatic fever and Tourette's disorder. Clin Diagn Lab Immunol 2004;11(2):330–6.

Singh RH, Kruger WD, Wang L, Pasquali M, Elsas LJ 2nd. Cystathionine beta-synthase deficiency: effects of betaine supplementation after methionine restriction in B6-nonresponsive homocystinuria. Genet Med 2004;6(2):90–5.

Frost M, Newell J, Lones MA, Tripp SR, Cairo MS, Perkins SL. Comparative immunohistochemical analysis of pediatric Burkitt lymphoma and diffuse large B-cell lymphoma. Am J Clin Pathol 2004;121(3):384–92.

Gunawardena K, Campbell LD, Meikle AW. Combination therapy with vitamins C plus E inhibits survivin and human prostate cancer cell growth. Prostate 2004;59(3):319–27.

Erickson JA, Ashwood ER, Gin CA. Evaluation of a dimeric inhibin-A assay for assessing fetal Down syndrome: establishment, comparison, and monitoring of median concentrations for normal pregnancies. Arch Pathol Lab Med 2004;128(4):415–20.

Meikle AW, Matthias D, Hoffman AR. Transdermal testosterone gel: pharmacokinetics, efficacy of dosing and application site in hypogonadal men. BJU Int 2004;93(6):789–95.

Iacobazzi V, Pasquali M, Singh R, Matern D, Rinaldo P, Amat di San Filippo C, Palmieri F, Longo N. Response to therapy in carnitine/acylcarnitine translocase (CACT) deficiency due to a novel missense mutation. Am J Med Genet A 2004;126(2):150–5.

Kushnir MM, Neilson R, Roberts WL, Rockwood AL. Cortisol and cortisone analysis in serum and plasma by atmospheric pressure photoionization tandem mass spectrometry. Clin Biochem 2004;37(5):357–62.

Chang CC, McClintock S, Cleveland RP, Trzpuc T, Vesole DH, Logan B, Kajdacsy-Balla A, Perkins SL. Immunohistochemical expression patterns of germinal center and activation B-cell markers correlate with prognosis in diffuse large B-cell lymphoma. Am J Surg Pathol 2004;28(4):464–70.

Lim MS, Elenitoba-Johnson KS. The molecular pathology of primary immunodeficiencies. J Mol Diagn 2004;6(2):59–83.

Lin Z, Jenson SD, Lim MS, Elenitoba-Johnson KS. Application of SELDI-TOF mass spectrometry for the identification of differentially expressed proteins in transformed follicular lymphoma. Mod Pathol 2004;17(6):670–8.

Bentz JS, Rowe LR, Anderson SR, Gupta PK, McGrath CM. Rapid detection of the t(11;14) translocation in mantle cell lymphoma by interphase fluorescence in situ hybridization on archival cytopathologic material. Cancer 2004;102(2):124–31.

Dunn JJ, Malan AK, Evans J, Litwin CM. Rapid detection of Mycoplasma pneumoniae IgM antibodies in pediatric patients using ImmunoCard Mycoplasma compared to conventional enzyme immunoassays. Eur J Clin Microbiol Infect Dis 2004;23(5):412–4.

Lones MA, Sanger WG, Le Beau MM, Heerema NA, Sposto R, Perkins SL, Buckley J, Kadin ME, Kjeldsberg CR, Meadows A, Siegel S, Finlay J, Bergeron S, Cair. Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas of children and adolescents: a report from Children's Cancer Group Study CCG-E08. J Pediatr Hematol Oncol 2004;26(3):169–78.

Meikle AW. The interrelationships between thyroid dysfunction and hypogonadism in men and boys. Thyroid 2004;14 Suppl 1:S17–25.

Roberts RF, Roberts WL. Performance characteristics of a recombinant enzymatic cycling assay for quantification of total homocysteine in serum or plasma. Clin Chim Acta 2004;344(1–2):95–9.

Lin Z, Crockett DK, Jenson SD, Lim MS, Elenitoba-Johnson KS. Quantitative proteomic and transcriptional analysis of the response to the p38 mitogen-activated protein kinase inhibitor SB203580 in transformed follicular lymphoma cells. Mol Cell Proteomics 2004;3(8):820–33.

Kushnir MM, Rockwood AL, Nelson GJ. Simultaneous quantitative analysis of isobars by tandem mass spectrometry from unresolved chromatographic peaks. J Mass Spectrom 2004;39(5):532–40.

Liu A, Kushnir MM, Roberts WL, Pasquali M. Solid phase extraction procedure for urinary organic acid analysis by gas chromatography mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2004;806(2):283–7.

McKinney JT, Longo N, Hahn SH, Matern D, Rinaldo P, Strauss AW, Dobrowolski SF. Rapid, comprehensive screening of the human medium chain acyl-CoA dehydrogenase gene. Mol Genet Metab 2004;82(2):112–20.

Byington CL, Enriquez FR, Hoff C, Tuohy R, Taggart EW, Hillyard DR, Carroll KC, Christenson JC. Serious bacterial infections in febrile infants 1 to 90 days old with and without viral infections. Pediatrics 2004;113(6):1662–6.

Pickering JW, McMillin GA, Gedge F, Hill HR, Lyon E. Flow cytometric assay for genotyping cytochrome p450 2C9 and 2C19: comparison with a microelectronic DNA array. Am J Pharmacogenomics 2004;4(3):199–207.

Rowe LR, Aldeen W, Bentz JS. Prevalence and typing of HPV DNA by hybrid capture II in women with ASCUS, ASC-H, LSIL, and AGC on ThinPrep Pap tests. Diagn Cytopathol 2004;30(6):426–32.

Roberts RF, Roberts WL. Performance characteristics of five automated serum cortisol immunoassays. Clin Biochem 2004;37(6):489–93.

Elgort MG, Herrmann MG, Erali M, Durtschi JD, Voelkerding KV, Smith RE. Extraction and amplification of genomic DNA from human blood on nanoporous aluminum oxide membranes. Clin Chem 2004;50(10):1817–9.

Jaskowski TD, Martins TB, Litwin CM, Hill HR. Immunoglobulin (Ig) M antibody against myelin associated glycoprotein (MAG): A comparison of methods. J Clin Lab Anal 2004;18(4):247–50.

Lundell R, Elenitoba-Johnson KS, Lim MS. T-cell posttransplant lymphoproliferative disorder occurring in a pediatric solid-organ transplant patient. Am J Surg Pathol 2004;28(7):967–73.

Liew M, Pryor R, Palais R, Meadows C, Erali M, Lyon E, Wittwer C. Genotyping of single-nucleotide polymorphisms by high-resolution melting of small amplicons. Clin Chem 2004;50(7):1156–64.

Robison JE, Perreard L, Bernard PS. State of the science: molecular classifications of breast cancer for clinical diagnostics. Clin Biochem 2004;37(7):572–8.

Zhou L, Vandersteen J, Wang L, Fuller T, Taylor M, Palais B, Wittwer CT. High-resolution DNA melting curve analysis to establish HLA genotypic identity. Tissue Antigens 2004;64(2):156–64.

Crist GA, Langer JM, Woods GL, Procter M, Hillyard DR. Evaluation of the ELVIS plate method for the detection and typing of herpes simplex virus in clinical specimens. Diagn Microbiol Infect Dis 2004;49(3):173–7.

Bayrak-Toydemir P, Mao R, Lewin S, McDonald J. Hereditary hemorrhagic telangiectasia: an overview of diagnosis and management in the molecular era for clinicians. Genet Med 2004;6(4):175–91.

Vaughn CP, Elenitoba-Johnson KS. High-resolution melting analysis for detection of internal tandem duplications. J Mol Diagn 2004;6(3):211–6.

Pont-Kingdon G, Jama M, Miller C, Millson A, Lyon E. Long-range (17.7 kb) allele-specific polymerase chain reaction method for direct haplotyping of R117H and IVS-8 mutations of the cystic fibrosis transmembrane regulator gene. J Mol Diagn 2004;6(3):264–70.

Flanders MM, Rodgers GM. Evaluation of a Russell's viper venom-based protein C assay. Thromb Haemost 2004;92(2):430–1.

Juenke JM, Brown PI, Urry FM, McMillin GA. Specimen dilution for C2 monitoring with the Abbott TDxFLx cyclosporine monoclonal whole blood assay. Clin Chem 2004;50(8):1430–3.

Szabo A, Perou CM, Karaca M, Perreard L, Quackenbush JF, Bernard PS. Statistical modeling for selecting housekeeper genes. Genome Biol 2004;5(8):R59.

Burt RW, Leppert MF, Slattery ML, Samowitz WS, Spirio LN, Kerber RA, Kuwada SK, Neklason DW, Disario JA, Lyon E, Hughes JP, Chey WY, White RL. Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis. Gastroenterology 2004;127(2):444–51.

Reed GH, Wittwer CT. Sensitivity and specificity of single-nucleotide polymorphism scanning by high-resolution melting analysis. Clin Chem 2004;50(10):1748–54.

Erali M, Durtschi JD, Voelkerding KV, Smith RE. Localization and imaging of nucleic acids on nanoporous aluminum oxide membranes. Clin Chem 2004;50(10):1819–21.

Margraf RL, Page S, Erali M, Wittwer CT. Single-tube method for nucleic acid extraction, amplification, purification, and sequencing. Clin Chem 2004;50(10):1755–61.

Lim MS, Elenitoba-Johnson KS. Proteomics in pathology research. Lab Invest 2004;84(10):1227–44.

Aldous WK, Gerber K, Taggart EW, Thomas J, Tidwell D, Daly JA. A comparison of Binax NOW to viral culture and direct fluorescent assay testing for respiratory syncytial virus. Diagn Microbiol Infect Dis 2004;49(4):265–8.

Dai T, Abou-Rjaily GA, Al-Share QY, Yang Y, Fernstrom MA, Deangelis AM, Lee AD, Sweetman L, Amato A, Pasquali M, Lopaschuk GD, Erickson SK, Najjar SM. Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice. J Biol Chem 2004;279(43):45155–61.

Lehman CM, Wilson LW, Rodgers GM. Analytic validation and clinical evaluation of the STA LIATEST immunoturbidimetric D-dimer assay for the diagnosis of disseminated intravascular coagulation. Am J Clin Pathol 2004;122(2):178–84.

Willmore C, Holden JA, Zhou L, Tripp S, Wittwer CT, Layfield LJ. Detection of c-kit-activating mutations in gastrointestinal stromal tumors by high-resolution amplicon melting analysis. Am J Clin Pathol 2004;122(2):206–16.

Chittamma A, Roberts WL, Sritara P, Cheepudomwit S, Suriyawongpaisal P, Lolekha PH. Comparison of two homogeneous HDL cholesterol methods in a large population study. Clin Biochem 2004;37(9):745–9.

Miles RR, Roberts RF, Putnam AR, Roberts WL. Comparison of serum and heparinized plasma samples for measurement of chemistry analytes. Clin Chem 2004;50(9):1704–6.

Lim MS, Elenitoba-Johnson KS. Ubiquitin ligases in malignant lymphoma. Leuk Lymphoma 2004;45(7):1329–39.

Yang DT, Owen WE, Ramsay CS, Xie H, Roberts WL. Performance characteristics of eight estradiol immunoassays. Am J Clin Pathol 2004;122(3):332–7.

Stevenson DA, Brothman AR, Chen Z, Bayrak-Toydemir P, Longo N. Paternal uniparental disomy of chromosome 14: confirmation of a clinically-recognizable phenotype. Am J Med Genet A 2004;130(1):88–91.

Bornhorst JA, Roberts RF, Roberts WL. Assay-specific differences in lipemic interference in native and intralipid-supplemented samples. Clin Chem 2004;50(11):2197–201.

Hartung L, Bahler DW. Flow cytometric analysis of BCL-2 can distinguish small numbers of acute lymphoblastic leukaemia cells from B-cell precursors. Br J Haematol 2004;127(1):50–8.

Rowe LR, Bentz JS. A simple method to determine the need for glacial acetic acid treatment of bloody ThinPrep Pap tests before slide processing. Diagn Cytopathol 2004;31(5):321–5.

Rawlins ML, Roberts WL. Performance characteristics of six third-generation assays for thyroid-stimulating hormone. Clin Chem 2004;50(12):2338–44.

Margraf RL, Erali M, Liew M, Wittwer CT. Genotyping hepatitis C virus by heteroduplex mobility analysis using temperature gradient capillary electrophoresis. J Clin Microbiol 2004;42(10):4545–51.

Mirrett S, Petti CA, Woods CW, Magadia R, Weinstein MP, Reller LB. Controlled clinical comparison of the BacT/ALERT FN and the standard anaerobic SN blood culture medium. J Clin Microbiol 2004;42(10):4581–5.

Lo SF, Doumas BT, Ashwood ER. Bilirubin proficiency testing using specimens containing unconjugated bilirubin and human serum: results of a College of American Pathologists study. Arch Pathol Lab Med 2004;128(11):1219–23.

Bryant KG, Horns KM, Longo N, Schiefelbein J. A primer on newborn screening. Adv Neonatal Care 2004;4(5):306–17.

Keller C, Hansen MS, Coffin CM, Capecchi MR. Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. Genes Dev 2004;18(21):2608–13.

Cloud JL, Shutt C, Aldous W, Woods G. Evaluation of a modified gen-probe amplified direct test for detection of Mycobacterium tuberculosis complex organisms in cerebrospinal fluid. J Clin Microbiol 2004;42(11):5341–4.

Polage C, Little RR, Rohlfing CL, Cole TG, Roberts WL. Effects of beta thalassemia minor on results of six glycated hemoglobin methods. Clin Chim Acta 2004;350(1–2):123–8.

Curtin K, Slattery ML, Holubkov R, Edwards S, Holden JA, Samowitz WS. p53 alterations in colon tumors: a comparison of SSCP/sequencing and immunohistochemistry. Appl Immunohistochem Mol Morphol 2004;12(4):380–6.

Martins TB, Burlingame R, von Muhlen CA, Jaskowski TD, Litwin CM, Hill HR. Evaluation of multiplexed fluorescent microsphere immunoassay for detection of autoantibodies to nuclear antigens. Clin Diagn Lab Immunol 2004;11(6):1054–9.

Taggart EW, Hill HR, Ruegner RG, Martins TB, Litwin CM. Evaluation of an in vitro assay for gamma interferon production in response to Mycobacterium tuberculosis infections. Clin Diagn Lab Immunol 2004;11(6):1089–93.

Dunin-Borkowski RE, Kasama T, Wei A, Tripp SL, Hytch MJ, Snoeck E, Harrison RJ, Putnis A. Off-axis electron holography of magnetic nanowires and chains, rings, and planar arrays of magnetic nanoparticles. Microsc Res Tech 2004;64(5–6):390–402.

Heider EC, Davis BG, Frank EL. Nonparametric determination of reference intervals for plasma metanephrine and normetanephrine. Clin Chem 2004;50(12):2381–4.

Stevenson DA, Carey JC, Cowley BC, Bayrak-Toydemir P, Mao R, Brothman AR. 4p terminal deletion and 11p subtelomeric duplication detected by genomic microarray in a patient with Wolf-Hirschhorn syndrome and an atypical phenotype. J Pediatr 2004;145(6):840–2.

Litwin CM, Johnson JM, Martins TB. The Bartonella henselae sucB gene encodes a dihydrolipoamide succinyltransferase protein reactive with sera from patients with cat-scratch disease. J Med Microbiol 2004;53(Pt 12):1221–7.

Roberts WL. CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: laboratory tests available to assess inflammation--performance and standardization: a background paper. Circulation 2004;110(25):e572–6.

Makhseed N, Vallance HD, Potter M, Waters PJ, Wong LT, Lillquist Y, Pasquali M, Amat di San Filippo C, Longo N. Carnitine transporter defect due to a novel mutation in the SLC22A5 gene presenting with peripheral neuropathy. J Inherit Metab Dis 2004;27(6):778–80.

Longo N, Fukao T, Singh R, Pasquali M, Barrios RG, Kondo N, Gibson KM. Succinyl-CoA:3-ketoacid transferase (SCOT) deficiency in a new patient homozygous for an R217X mutation. J Inherit Metab Dis 2004;27(5):691–2.