The Institute for Clinical and Experimental Research® is focused on the development of new diagnostic assays in a wide range of disciplines. Researchers at the institute regularly publish in respected, peer-reviewed journals, give presentations at national and international organizations, author books and book chapters, and develop new tests.

There are 76 total entries for the year 2003.

Chang CP, Chia RH, Wu TL, Tsao KC, Sun CF, Wu JT. Elevated cell-free serum DNA detected in patients with myocardial infarction. Clin Chim Acta 2003;327(1–2):95–101.
Flanders MM, Crist R, Rodgers GM. Comparison of five thrombin time reagents. Clin Chem 2003;49(1):169–72.
Layfield LJ, Gopez EV. Percutaneous image-guided fine-needle aspiration of peritoneal lesions. Diagn Cytopathol 2003;28(1):6–12.
Zhou H, Randall RL, Brothman AR, Maxwell T, Coffin CM, Goldsby RE. Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification. J Pediatr Hematol Oncol 2003;25(1):27–32.
Terry AH, Orrock J, Meikle AW. Comparison of two third-generation parathyroid hormone assays. Clin Chem 2003;49(2):336–7.
Chang CC, Kampalath B, Schultz C, Bunyi-Teopengco E, Logan B, Eshoa C, Dincer AP, Perkins SL. Expression of p53, c-Myc, or Bcl-6 suggests a poor prognosis in primary central nervous system diffuse large B-cell lymphoma among immunocompetent individuals. Arch Pathol Lab Med 2003;127(2):208–12.
Raetz E, Perkins S, Davenport V, Cairo MS. B large-cell lymphoma in children and adolescents. Cancer Treat Rev 2003;29(2):91–8.
Sabesan V, Cairo MS, Lones MA, Perkins SL, Morris E, Sposto R, Van De Ven C, Shiramizu B. Assessment of minimal residual disease in childhood non-hodgkin lymphoma by polymerase chain reaction using patient-specific primers. J Pediatr Hematol Oncol 2003;25(2):109–13.
Carroll KC, Adamson K, Korgenski K, Croft A, Hankemeier R, Daly J, Park CH. Comparison of a commercial reversed passive latex agglutination assay to an enzyme immunoassay for the detection of Shiga toxin-producing Escherichia coli. Eur J Clin Microbiol Infect Dis 2003;22(11):689–92.
Putnam A, Yandow S, Coffin CM. Classic adamantinoma with osteofibrous dysplasia-like foci and secondary aneurysmal bone cyst. Pediatr Dev Pathol 2003;6(2):173–8.
Matsumoto SS, Biggs J, Copp BR, Holden JA, Barrows LR. Mechanism of ascididemin-induced cytotoxicity. Chem Res Toxicol 2003;16(2):113–22.
Cairo MS, Sposto R, Perkins SL, Meadows AT, Hoover-Regan ML, Anderson JR, Siegel SE, Lones MA, Tedeschi-Blok N, Kadin ME, Kjeldsberg CR, Wilson JF, Sa. Burkitt's and Burkitt-like lymphoma in children and adolescents: a review of the Children's Cancer Group experience. Br J Haematol 2003;120(4):660–70.
Newell JO, Cessna MH, Greenwood J, Hartung L, Bahler DW. Importance of CD117 in the evaluation of acute leukemias by flow cytometry. Cytometry B Clin Cytom 2003;52(1):40–3.
Gundry CN, Vandersteen JG, Reed GH, Pryor RJ, Chen J, Wittwer CT. Amplicon melting analysis with labeled primers: a closed-tube method for differentiating homozygotes and heterozygotes. Clin Chem 2003;49(3):396–406.
Judd AM, Best KB, Christensen K, Rodgers GM, Bell JD. Alterations in sensitivity to calcium and enzymatic hydrolysis of membranes from sickle cell disease and trait erythrocytes. Am J Hematol 2003;72(3):162–9.
Schussler JM, Juenke JM, Schussler I. Quetiapine and falsely elevated nortriptyline level. Am J Psychiatry 2003;160(3):589.
Yu Y, Eriksson P, Bhoite LT, Stillman DJ. Regulation of TATA-binding protein binding by the SAGA complex and the Nhp6 high-mobility group protein. Mol Cell Biol 2003;23(6):1910–21.
Hong B, Chen Z, Coffin CM, Lemons R, Issa B, Brothman A, Zhou H. Molecular cytogenetic analysis of a pleuropulmonary blastoma. Cancer Genet Cytogenet 2003;142(1):65–9.
Dunn JJ, Billetdeaux E, Skodack-Jones L, Carroll KC. Evaluation of three Copan viral transport systems for the recovery of cultivatable, clinical virus isolates. Diagn Microbiol Infect Dis 2003;45(3):191–7.
Botkin JR, Smith KR, Croyle RT, Baty BJ, Wylie JE, Dutson D, Chan A, Hamann HA, Lerman C, McDonald J, Venne V, Ward JH, Lyon E. Genetic testing for a BRCA1 mutation: prophylactic surgery and screening behavior in women 2 years post testing. Am J Med Genet A 2003;118(3):201–9.
Rockwood AL, Kushnir MM, Nelson GJ. Dissociation of individual isotopic peaks: predicting isotopic distributions of product ions in MSn. J Am Soc Mass Spectrom 2003;14(4):311–22.
Tsao KC, Chang PY, Li CC, Wu TL, Sun CF, Wu JT. Development of a microplate ELISA for circulating E-selectin: assay characterization, comparison with a commercial kit, wand establishment of normal reference values. J Clin Lab Anal 2003;17(3):97–101.
Reading NS, Jenson SD, Smith JK, Lim MS, Elenitoba-Johnson KS. 5'-(RACE) identification of rare ALK fusion partner in anaplastic large cell lymphoma. J Mol Diagn 2003;5(2):136–40.
Erali M, Schmidt B, Lyon E, Wittwer C. Evaluation of electronic microarrays for genotyping factor V, factor II, and MTHFR. Clin Chem 2003;49(5):732–9.
Malan AK, Stipanovich PJ, Martins TB, Hill HR, Litwin CM. Detection of IgG and IgM to West Nile virus. Development of an immunofluorescence assay. Am J Clin Pathol 2003;119(4):508–15.
Dunn JJ, Gordon C, Kelley C, Carroll KC. Comparison of the Denka-Seiken INFLU A.B-Quick and BD Directigen Flu A+B kits with direct fluorescent-antibody staining and shell vial culture methods for rapid detection of influenza viruses. J Clin Microbiol 2003;41(5):2180–3.
La Pine TR, Joyner JL, Augustine NH, Kwak SD, Hill HR. Defective production of IL-18 and IL-12 by cord blood mononuclear cells influences the T helper-1 interferon gamma response to group B Streptococci. Pediatr Res 2003;54(2):276–81.
Hendrickson BC, Pruss D, Lyon E, Scholl T. Application of haplotype pair analysis for the identification of hemizygous loci. J Med Genet 2003;40(5):346–7.
Elenitoba-Johnson KS, Jenson SD, Abbott RT, Palais RA, Bohling SD, Lin Z, Tripp S, Shami PJ, Wang LY, Coupland RW, Buckstein R, Perez-Ordonez B, Perki. Involvement of multiple signaling pathways in follicular lymphoma transformation: p38-mitogen-activated protein kinase as a target for therapy. Proc Natl Acad Sci U S A 2003;100(12):7259–64.
Owen WE, Roberts WL. Performance characteristics of four immunonephelometric assays for the quantitative determination of IgA and IgM in cerebrospinal fluid. Am J Clin Pathol 2003;119(5):689–93.
Wittwer CT, Reed GH, Gundry CN, Vandersteen JG, Pryor RJ. High-resolution genotyping by amplicon melting analysis using LCGreen. Clin Chem 2003;49(6 Pt 1):853–60.
Kushnir MM, Rockwood AL, Nelson GJ, Terry AH, Meikle AW. Liquid chromatography-tandem mass spectrometry analysis of urinary free cortisol. Clin Chem 2003;49(6 Pt 1):965–7.
Erickson JA, Cousin R, Wu JT, Ashwood ER. Quantitative spectrophotometric microplate assay for angiotensin-converting enzyme in cerebrospinal fluid. Clin Chem 2003;49(6 Pt 1):970–2.
Mirrett S, Reller LB, Petti CA, Woods CW, Vazirani B, Sivadas R, Weinstein MP. Controlled clinical comparison of BacT/ALERT standard aerobic medium with BACTEC standard aerobic medium for culturing blood. J Clin Microbiol 2003;41(6):2391–4.
Abbott RT, Tripp S, Perkins SL, Elenitoba-Johnson KS, Lim MS. Analysis of the PI-3-Kinase-PTEN-AKT pathway in human lymphoma and leukemia using a cell line microarray. Mod Pathol 2003;16(6):607–12.
Lin Z, Fillmore GC, Um TH, Elenitoba-Johnson KS, Lim MS. Comparative microarray analysis of gene expression during activation of human peripheral blood T cells and leukemic Jurkat T cells. Lab Invest 2003;83(6):765–76.
De BK, Roberts WL. Performance characteristics of the Dimension RxL iron and total iron-binding capacity methods. Clin Chim Acta 2003;333(1):51–7.
Bennett CD, Campbell MN, Cook CJ, Eyre DJ, Nay LM, Nielsen DR, Rasmussen RP, Bernard PS. The LightTyper: high-throughput genotyping using fluorescent melting curve analysis. Biotechniques 2003;34(6):1288–92, 1294–5.
Pont-Kingdon G, Lyon E. Rapid detection of aneuploidy (trisomy 21) by allele quantification combined with melting curves analysis of single-nucleotide polymorphism loci. Clin Chem 2003;49(7):1087–94.
Juenke JM, Brown PI, McMillin GA, Urry FM. Procedure for the monitoring of gabapentin with 2,4,6-trinitrobenzene sulfonic acid derivatization followed by HPLC with ultraviolet detection. Clin Chem 2003;49(7):1198–201.
Vaughn CP, Elenitoba-Johnson KS. Hybridization-induced dequenching of fluorescein-labeled oligonucleotides: a novel strategy for PCR detection and genotyping. Am J Pathol 2003;163(1):29–35.
Meda BA, Frost M, Newell J, Bohling SD, Huebner-Chan DR, Perkins SL, Lim MS, Medeiros LJ, Elenitoba-Johnson KS. BCL-2 is consistently expressed in hyperplastic marginal zones of the spleen, abdominal lymph nodes, and ileal lymphoid tissue. Am J Surg Pathol 2003;27(7):888–94.
Malan AK, Martins TB, Jaskowski TD, Hill HR, Litwin CM. Comparison of two commercial enzyme-linked immunosorbent assays with an immunofluorescence assay for detection of Legionella pneumophila types 1 to 6. J Clin Microbiol 2003;41(7):3060–3.
Owen WE, Roberts WL. Comparison of five automated serum and whole blood folate assays. Am J Clin Pathol 2003;120(1):121–6.
Cloud JL, Hymas WC, Turlak A, Croft A, Reischl U, Daly JA, Carroll KC. Description of a multiplex Bordetella pertussis and Bordetella parapertussis LightCycler PCR assay with inhibition control. Diagn Microbiol Infect Dis 2003;46(3):189–95.
Rao G, Pedone CA, Coffin CM, Holland EC, Fults DW. c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice. Neoplasia 2003;5(3):198–204.
Petti CA, Fowler VG Jr. Staphylococcus aureus bacteremia and endocarditis. Cardiol Clin 2003;21(2):219–33, vii.
Millson A, Suli A, Hartung L, Kunitake S, Bennett A, Nordberg MC, Hanna W, Wittwer CT, Seth A, Lyon E. Comparison of two quantitative polymerase chain reaction methods for detecting HER2/neu amplification. J Mol Diagn 2003;5(3):184–90.
Melis R, Pruett PB, Wang Y, Longo N. Gene expression in human cells with mutant insulin receptors. Biochem Biophys Res Commun 2003;307(4):1013–20.
Layfield LJ, Bernard PS, Goldstein NS. Color multiplex polymerase chain reaction for quantitative analysis of epidermal growth factor receptor genes in colorectal adenocarcinoma. J Surg Oncol 2003;83(4):227–31.
Voth WP, Jiang YW, Stillman DJ. New 'marker swap' plasmids for converting selectable markers on budding yeast gene disruptions and plasmids. Yeast 2003;20(11):985–93.
Meikle AW, Findling J, Kushnir MM, Rockwood AL, Nelson GJ, Terry AH. Pseudo-Cushing syndrome caused by fenofibrate interference with urinary cortisol assayed by high-performance liquid chromatography. J Clin Endocrinol Metab 2003;88(8):3521–4.
Rowe LR, Marshall CJ, Berry M, Larson MA, Bentz JS. Accuracy of a slide profiler for endocervical cell detection in no-further-review conventional Pap smears. Acta Cytol 2003;47(4):602–4.
Layfield LJ. Cytologic differential diagnosis of myxoid and mucinous neoplasms of the sacrum and parasacral soft tissues. Diagn Cytopathol 2003;99(4):217–22.
Layfield LJ, Wax T, Jones C. Cytologic distinction of goiterous nodules from morphologically normal thyroid: analyses of cytomorphologic features. Cancer 2003;99(4):217–22.
Jasionowski TM, Hartung L, Greenwood JH, Perkins SL, Bahler DW. Analysis of CD10+ hairy cell leukemia. Am J Clin Pathol 2003;120(2):228–35.
House P, Dunn J, Carroll K, MacDonald J. Seeding of a cavernous angioma with Mycoplasma hominis: case report. Neurosurgery 2003;53(3):749–52; discussion 752–3.
Lyon E, Miller C. Current challenges in cystic fibrosis screening. Arch Pathol Lab Med 2003;127(9):1133–9.
Pont-Kingdon G. Creation of chimeric junctions, deletions, and insertions by PCR. Methods Mol Biol 2003;226:511–6.
Garcia-Villalba P, Denkers ND, Wittwer CT, Hoff C, Nelson RD, Mauch TJ. Real-time PCR quantification of AT1 and AT2 angiotensin receptor mRNA expression in the developing rat kidney. Nephron Exp Nephrol 2003;94(4):e154–9.
Voth WP, Stillman DJ. Changes in developmental state: demolish the old to construct the new. Genes Dev 2003;17(18):2201–4.
Chang CC, Osipov V, Wheaton S, Tripp S, Perkins SL. Follicular hyperplasia, follicular lysis, and progressive transformation of germinal centers. A sequential spectrum of morphologic evolution in lymphoid hyperplasia. Am J Clin Pathol 2003;120(3):322–6.
Imperial JS, Watkins M, Chen P, Hillyard DR, Cruz LJ, Olivera BM. The augertoxins: biochemical characterization of venom components from the toxoglossate gastropod Terebra subulata. Toxicon 2003;42(4):391–8.
Amat di San Filippo C, Wang Y, Longo N. Functional domains in the carnitine transporter OCTN2, defective in primary carnitine deficiency. J Biol Chem 2003;278(48):47776–84.
Litwin CM. Pet-transmitted infections: diagnosis by microbiologic and immunologic methods. Pediatr Infect Dis J 2003;22(9):768–77.
Zhou H, Coffin CM, Perkins SL, Tripp SR, Liew M, Viskochil DH. Malignant peripheral nerve sheath tumor: a comparison of grade, immunophenotype, and cell cycle/growth activation marker expression in sporadic and neurofibromatosis 1-related lesions. Am J Surg Pathol 2003;27(10):1337–45.
Makitie AA, Chau M, Lim S, Viani MA, Gilbert R, Lim MS, Jordan RC. Selective inhibition of cyclooxygenase 2 induces p27kip1 and skp2 in oral squamous cell carcinoma. J Otolaryngol 2003;32(4):226–9.
Zhou L, Yue B, Dearden DV, Lee ED, Rockwood AL, Lee ML. Incorporation of a venturi device in electrospray ionization. Anal Chem 2003;75(21):5978–83.
Nodit L, Bahler DW, Jacobs SA, Locker J, Swerdlow SH. Indolent mantle cell lymphoma with nodal involvement and mutated immunoglobulin heavy chain genes. Hum Pathol 2003;34(10):1030–4.
Jenson SD, Robetorye RS, Bohling SD, Schumacher JA, Morgan JW, Lim MS, Elenitoba-Johnson KS. Validation of cDNA microarray gene expression data obtained from linearly amplified RNA. Mol Pathol 2003;56(6):307–12.
Layfield LJ, Jones C, Hirschowitz S. Statistical analysis of cytologic features useful in separation of metastatic urothelial carcinoma from other metastatic epithelial malignancies. Diagn Cytopathol 2003;29(6):334–8.
Garrison S, Hojgaard A, Margraf R, Weis JJ, Weis JH. Surface translocation of pactolus is induced by cell activation and death, but is not required for neutrophil migration and function. J Immunol 2003;171(12):6795–806.
Dunn JJ, Wolfe MJ, Trachtenberg J, Kriesel JD, Orlandi RR, Carroll KC. Invasive fungal sinusitis caused by Scytalidium dimidiatum in a lung transplant recipient. J Clin Microbiol 2003;41(12):5817–9.
Lin Z, Crockett DK, Lim MS, Elenitoba-Johnson KS. High-throughput analysis of protein/peptide complexes by immunoprecipitation and automated LC-MS/MS. J Biomol Tech 2003;14(2):149–55.
Mellmann A, Cloud JL, Andrees S, Blackwood K, Carroll KC, Kabani A, Roth A, Harmsen D. Evaluation of RIDOM, MicroSeq, and Genbank services in the molecular identification of Nocardia species. Int J Med Microbiol 2003;293(5):359–70.
Lowichik A, Jackson WD, Coffin CM. Gastrointestinal polyposis in childhood: clinicopathologic and genetic features. Pediatr Dev Pathol 2003;6(5):371–91.
Perkins SL, Lones MA, Davenport V, Cairo MS. B-Cell non-Hodgkin's lymphoma in children and adolescents: surface antigen expression and clinical implications for future targeted bioimmune therapy: a children's cancer group report. Clin Adv Hematol Oncol 2003;1(5):314–7.