The Institute for Clinical and Experimental Research® is focused on the development of new diagnostic assays in a wide range of disciplines. Researchers at the institute regularly publish in respected, peer-reviewed journals, give presentations at national and international organizations, author books and book chapters, and develop new tests.

There are 71 total entries for the year 2002.

Layfield LJ, Jones C, Rowe L, Gopez EV. Institutional review of outside cytology materials: a retrospective analysis of two institutions' experiences. Diagn Cytopathol 2002;26(1):45–8.
Byington CL, Spencer LY, Johnson TA, Pavia AT, Allen D, Mason EO, Kaplan S, Carroll KC, Daly JA, Christenson JC, Samore MH. An epidemiological investigation of a sustained high rate of pediatric parapneumonic empyema: risk factors and microbiological associations. Clin Infect Dis 2002;34(4):434–40.
Kushnir MM, Urry FM, Frank EL, Roberts WL, Shushan B. Analysis of catecholamines in urine by positive-ion electrospray tandem mass spectrometry. Clin Chem 2002;48(2):323–31.
Crockett DK, Frank EL, Roberts WL. Rapid analysis of metanephrine and normetanephrine in urine by gas chromatography-mass spectrometry. Clin Chem 2002;48(2):332–7.
Roberts WL, De BK, Brown D, Hanbury CM, Hoyer JD, John WG, Lambert TL, Lundell RB, Rohlfing C, Little RR. Effects of hemoglobin C and S traits on eight glycohemoglobin methods. Clin Chem 2002;48(2):383–5.
Perkins SL, Kim JE, Pollack JS, Merrill PT. Clinical characteristics of central serous chorioretinopathy in women. Ophthalmology 2002;109(2):262–6.
Cloud JL, Neal H, Rosenberry R, Turenne CY, Jama M, Hillyard DR, Carroll KC. Identification of Mycobacterium spp. by using a commercial 16S ribosomal DNA sequencing kit and additional sequencing libraries. J Clin Microbiol 2002;40(2):400–6.
Liu T, Raetz E, Moos PJ, Perkins SL, Bruggers CS, Smith F, Carroll WL. Diversity of the apoptotic response to chemotherapy in childhood leukemia. Leukemia 2002;16(2):223–32.
Konnick EQ, Erali M, Ashwood ER, Hillyard DR. Performance characteristics of the COBAS Amplicor Hepatitis C Virus (HCV) Monitor, Version 2.0, International Unit assay and the National Genetics Institute HCV Superquant assay. J Clin Microbiol 2002;40(3):768–73.
Bentz JS, Rowe LR, Gopez EV, Marshall CJ. The unsatisfactory ThinPrep Pap Test: missed opportunity for disease detection? Am J Clin Pathol 2002;117(3):457–63.
Bentz JS, Knoblock RJ. FNA contamination. Diagn Cytopathol 2002;26(3):199–200.
Liew MA, Coffin CM, Fletcher JA, Hang MT, Tanito K, Niimura M, Viskochil D. Peripheral nerve sheath tumors from patients with neurofibromatosis type 1 do not have the chromosomal translocation t(X;18). Pediatr Dev Pathol 2002;5(2):165–9.
Rubin MA, Carroll KC, Cahill BC. Caspofungin in combination with itraconazole for the treatment of invasive aspergillosis in humans. Clin Infect Dis 2002;34(8):1160–1.
Pickering JW, Martins TB, Greer RW, Schroder MC, Astill ME, Litwin CM, Hildreth SW, Hill HR. A multiplexed fluorescent microsphere immunoassay for antibodies to pneumococcal capsular polysaccharides. Am J Clin Pathol 2002;117(4):589–96.
Chang CC, Cleveland RP, Perkins SL. CD10 expression and survival. Am J Clin Pathol 2002;117(4):660–1; author reply 661–2.
Jones C, Liu K, Hirschowitz S, Klipfel N, Layfield LJ. Concordance of histopathologic and cytologic grading in musculoskeletal sarcomas: can grades obtained from analysis of the fine-needle aspirates serve as the basis for therapeutic decisions? Cancer 2002;96(2):83–91.
Knoblock RJ, Lehman CM, Smith RA, Apple FS, Roberts WL. False-positive AxSYM cardiac troponin I results in a 53-year-old woman. Arch Pathol Lab Med 2002;126(5):606–9.
Jaskowski TD, Martins TB, Litwin CM, Hill HR. Comparison of four enzyme immunoassays for the detection of immunoglobulin G antibody against glomerular basement membrane. J Clin Lab Anal 2002;16(3):143–5.
Lones MA, Perkins SL, Sposto R, Tedeschi N, Kadin ME, Kjeldsberg CR, Wilson JF, Zwick DL, Cairo MS. Non-Hodgkin's lymphoma arising in bone in children and adolescents is associated with an excellent outcome: a Children's Cancer Group report. J Clin Oncol 2002;20(9):2293–301.
Smith LM, Anderson JR, Coffin CM. Cytodifferentiation and clinical outcome after chemotherapy and radiation therapy for rhabdomyosarcoma (RMS). Med Pediatr Oncol 2002;38(6):398–404.
Elenitoba-Johnson KS, Bohling SD, Jenson SD, Lin Z, Monnin KA, Lim MS. Fluorescence PCR quantification of cyclin D1 expression. J Mol Diagn 2002;4(2):90–6.
Layfield LJ, Gopez EV. Histologic and fine-needle aspiration cytologic features of polycystic disease of the parotid glands: case report and review of the literature. Diagn Cytopathol 2002;26(5):324–8.
Yu MK, Rodgers GM. Immune-mediated thrombocytopenia associated with valley fever. Am J Hematol 2002;70(1):81–2.
Herron MD, Coffin CM, Vanderhooft SL. Annular elastolytic giant cell granuloma. Pediatr Dev Pathol 2002;5(3):305–9.
Bunch TJ, Abraham D, Wang S, Meikle AW. Pituitary radiographic abnormalities and clinical correlates of hypogonadism in elderly males presenting with erectile dysfunction. Aging Male 2002;5(1):38–46.
Kelly KM, Hutchinson RJ, Sposto R, Weiner MA, Lones MA, Perkins SL, Massey V. Feasibility of upfront dose-intensive chemotherapy in children with advanced-stage Hodgkin's lymphoma: preliminary results from the Children's Cancer Group Study CCG-59704. Ann Oncol 2002;13 Suppl 1:107–11.
Gelman SS, Gundlapalli AV, Hale D, Croft A, Hindiyeh M, Carroll KC. Spotting the spirochete: rapid diagnosis of leptospirosis in two returned travelers. J Travel Med 2002;9(3):165–7.
Kushnir MM, Shushan B, Roberts WL, Pasquali M. Serum acylcarnitines and vitamin B12 deficiency. Clin Chem 2002;48(7):1126–8.
Dunn JJ, Columbus ST, Aldeen WE, Davis M, Carroll KC. Trichuris vulpis recovered from a patient with chronic diarrhea and five dogs. J Clin Microbiol 2002;40(7):2703–4.
Coffin CM, Hamilton MS, Pysher TJ, Bach P, Ashwood E, Schweiger J, Monahan D, Perry D, Rogers BB, Brugnara C, Rutledge J, Weiss R, Ash O, Hill H, Meik. Pediatric laboratory medicine: current challenges and future opportunities. Am J Clin Pathol 2002;117(5):683–90.
Weiss RL, Sundwall D, Matsen JM. Estimating the budgetary impact of setting the medicare clinical laboratory fee schedule at the national limitation amount. Am J Clin Pathol 2002;117(5):691–5.
Pickering JW, Martins TB, Schroder MC, Hill HR. Comparison of a multiplex flow cytometric assay with enzyme-linked immunosorbent assay for auantitation of antibodies to tetanus, diphtheria, and Haemophilus influenzae Type b. Clin Diagn Lab Immunol 2002;9(4):872–6.
Fillmore GC, Lin Z, Bohling SD, Robetorye RS, Kim CH, Jenson SD, Elenitoba-Johnson KS, Lim MS. Gene expression profiling of cell lines derived from T-cell malignancies. FEBS Lett 2002;522(1–3):183–8.
Gunawardena K, Murray DK, Meikle AW. Testosterone is a potential augmentor of antioxidant-induced apoptosis in human prostate cancer cells. Cancer Detect Prev 2002;26(2):105–13.
Bahler DW, Pindzola JA, Swerdlow SH. Splenic marginal zone lymphomas appear to originate from different B cell types. Am J Pathol 2002;161(1):81–8.
Frank EL, Schwarz EL, Juenke J, Annesley TM, Roberts WL. Performance characteristics of four immunoassays for antiepileptic drugs on the IMMULITE 2000 automated analyzer. Am J Clin Pathol 2002;118(1):124–31.
Layfield LJ, Gopez EV. Fine-needle aspiration cytology of giant cell fibroblastoma: case report and review of the literature. Diagn Cytopathol 2002;26(6):398–403.
De BK, Smith LG, Owen WE, Roberts WL. Performance characteristics of an automated high-sensitivity C-reactive protein assay on the Dimension RXL analyzer. Clin Chim Acta 2002;323(1–2):151–5.
Bernard PS, Wittwer CT. Real-time PCR technology for cancer diagnostics. Clin Chem 2002;48(8):1178–85.
Millward H, Samowitz W, Wittwer CT, Bernard PS. Homogeneous amplification and mutation scanning of the p53 gene using fluorescent melting curves. Clin Chem 2002;48(8):1321–8.
Hess JR, Hill HR, Oliver CK, Lippert LE, Greenwalt TJ. Alkaline CPD and the preservation of RBC 2,3-DPG. Transfusion 2002;42(6):747–52.
Robetorye RS, Bohling SD, Morgan JW, Fillmore GC, Lim MS, Elenitoba-Johnson KS. Microarray analysis of B-cell lymphoma cell lines with the t(14;18). J Mol Diagn 2002;4(3):123–36.
Taggart EW, Carroll KC, Byington CL, Crist GA, Hillyard DR. Use of heat labile UNG in an RT-PCR assay for enterovirus detection. J Virol Methods 2002;105(1):57–65.
McMillin GA, Owen WE, Lambert TL, De BK, Frank EL, Bach PR, Annesley TM, Roberts WL. Comparable effects of DIGIBIND and DigiFab in thirteen digoxin immunoassays. Clin Chem 2002;48(9):1580–4.
Flanders MM, Crist R, Safapour S, Rodgers GM. Evaluation and performance characteristics of the STA-R coagulation analyzer. Clin Chem 2002;48(9):1622–4.
Williams SM, Meadows CA, Lyon E. Automated DNA extraction for real-time PCR. Clin Chem 2002;48(9):1629–30.
Carroll KC. Laboratory diagnosis of lower respiratory tract infections: controversy and conundrums. J Clin Microbiol 2002;40(9):3115–20.
Zhou H, Perkins SL, Tripp S, Hussong JW, Coffin CM. Expression of apoptosis-related antigens, Fas, bcl-2, and p53, and Mib-1 proliferation index in the hypoplastic thymus of DiGeorge syndrome. Pediatr Dev Pathol 2002;5(5):465–71.
Raetz EA, Perkins SL, Carlson MA, Schooler KP, Carroll WL, Virshup DM. The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas. Am J Pathol 2002;161(3):875–83.
Cessna MH, Zhou H, Sanger WG, Perkins SL, Tripp S, Pickering D, Daines C, Coffin CM. Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases. Mod Pathol 2002;15(9):931–8.
Martins TB, Pasi BM, Pickering JW, Jaskowski TD, Litwin CM, Hill HR. Determination of cytokine responses using a multiplexed fluorescent microsphere immunoassay. Am J Clin Pathol 2002;118(3):346–53.
Smith LM, Hu P, Meyer LJ, Coffin CM. Complex karyotypic abnormality in ovarian fibroma associated with Gorlin syndrome. Am J Med Genet 2002;112(1):61–4.
Gunawardena K, Murray DK, Swope RE, Meikle AW. Inhibition of nuclear factor kappaB induces apoptosis following treatment with tumor necrosis factor alpha and an antioxidant in human prostate cancer cells. Cancer Detect Prev 2002;26(3):229–37.
Hawker CD, Garr SB, Hamilton LT, Penrose JR, Ashwood ER, Weiss RL. Automated transport and sorting system in a large reference laboratory: part 1. Evaluation of needs and alternatives and development of a plan. Clin Chem 2002;48(10):1751–60.
Hawker CD, Roberts WL, Garr SB, Hamilton LT, Penrose JR, Ashwood ER, Weiss RL. Automated transport and sorting system in a large reference laboratory: part 2. Implementation of the system and performance measures over three years. Clin Chem 2002;48(10):1761–7.
Lim MS, Adamson A, Lin Z, Perez-Ordonez B, Jordan RC, Tripp S, Perkins SL, Elenitoba-Johnson KS. Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: correlation with p27(Kip1) and proliferation index. Blood 2002;100(8):2950–6.
Cloud JL, Hymas W, Carroll KC. Impact of nasopharyngeal swab types on detection of Bordetella pertussis by PCR and culture. J Clin Microbiol 2002;40(10):3838–40.
Layfield LJ, Gopez EV. Cystic lesions of the salivary glands: cytologic features in fine-needle aspiration biopsies. Diagn Cytopathol 2002;27(4):197–204.
Ford CD, Greenwood J, Strupp A, Lehman CM. Change in CD34+ cell concentration during peripheral blood progenitor cell collection: effects on collection efficiency and efficacy. Transfusion 2002;42(7):904–11.
Herron MD, Coffin CM, Vanderhooft SL. Tufted angiomas: variability of the clinical morphology. Pediatr Dermatol 2002;19(5):394–401.
Slayton WB, Georgelas A, Pierce LJ, Elenitoba-Johnson KS, Perry SS, Marx M, Spangrude GJ. The spleen is a major site of megakaryopoiesis following transplantation of murine hematopoietic stem cells. Blood 2002;100(12):3975–82.
Reid SD, Green NM, Sylva GL, Voyich JM, Stenseth ET, DeLeo FR, Palzkill T, Low DE, Hill HR, Musser JM. Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response. J Bacteriol 2002;184(22):6316–24.
e-rich large B-cell lymphoma: a heterogeneous entity with derivation from germinal center B cells. Am J Surg Pathol 2002;26(11):1458–66.
Rowe LR, Marshall CJ, Bentz JS. PREPmate automated processor: comparison of automated and manual methods of liquid-based gynecologic sample preparation. Diagn Cytopathol 2002;27(5):312–5.
Elenitoba-Johnson KS. Assessment of clonal relationships in malignant lymphomas. Methods Enzymol 2002;356:224–40.
Chandler WL, Rodgers GM, Sprouse JT, Thompson AR. Elevated hemostatic factor levels as potential risk factors for thrombosis. Arch Pathol Lab Med 2002;126(11):1405–14.
Smoot LM, McCormick JK, Smoot JC, Hoe NP, Strickland I, Cole RL, Barbian KD, Earhart CA, Ohlendorf DH, Veasy LG, Hill HR, Leung DY, Schlievert PM, Mus. Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks. Infect Immun 2002;70(12):7095–104.
Byington CL, Zerr DM, Taggart EW, Nguy L, Hillyard DR, Carroll KC, Corey L. Human herpesvirus 6 infection in febrile infants ninety days of age and younger. Pediatr Infect Dis J 2002;21(11):996–9.
Chung CH, Bernard PS, Perou CM. Molecular portraits and the family tree of cancer. Nat Genet 2002;32 Suppl:533–40.
Monk BJ, Cogan M, Felix JC, Lonky NM, Bentz JS, Marshall CJ, Cestero RM, Rowe LR, Lonky SA. A stiff bristled, spiral-shaped ectocervical brush: a device for transepithelial tissue biopsy. Obstet Gynecol 2002;100(6):1276–84.
Rowe LR, Marshall CJ, Bentz JS. One hundred percent thorough quality control rescreening of liquid-based monolayers in cervicovaginal cytopathology. Cancer 2002;96(6):325–9.