The Institute for Clinical and Experimental Research® is focused on the development of new diagnostic assays in a wide range of disciplines. Researchers at the institute regularly publish in respected, peer-reviewed journals, give presentations at national and international organizations, author books and book chapters, and develop new tests.

There are 77 total entries for the year 2001.

Peng H, Cheung AK, Reimer LG, Kamerath CD, Leypoldt JK. Effect of indomethacin on peritoneal protein loss in a rabbit model of peritonitis. Kidney Int 2001;59(1):44–51.
Hindiyeh M, Acevedo V, Carroll KC. Comparison of three transport systems (Starplex StarSwab II, the new Copan Vi-Pak Amies Agar Gel collection and transport swabs, and BBL Port-A-Cul) for maintenance of anaerobic and fastidious aerobic organisms. J Clin Microbiol 2001;39(1):377–80.
McDonald LC, Weinstein MP, Fune J, Mirrett S, Reimer LG, Reller LB. Controlled comparison of BacT/ALERT FAN aerobic medium and BATEC fungal blood culture medium for detection of fungemia. J Clin Microbiol 2001;39(2):622–4.
Neerhof MG, Haney EI, Silver RK, Ashwood ER, Lee IS, Piazze JJ. Lamellar body counts compared with traditional phospholipid analysis as an assay for evaluating fetal lung maturity. Obstet Gynecol 2001;97(2):305–9.
Neerhof MG, Dohnal JC, Ashwood ER, Lee IS, Anceschi MM. Lamellar body counts: a consensus on protocol. Obstet Gynecol 2001;97(2):318–20.
Rowe LR, Marshall CJ, Bentz JS. Cell block preparation as an adjunctive diagnostic technique in ThinPrep monolayer preparations: a case report. Diagn Cytopathol 2001;24(2):142–4.
Elenitoba-Johnson KS, Bohling SD, Wittwer CT, King TC. Multiplex PCR by multicolor fluorimetry and fluorescence melting curve analysis. Nat Med 2001;7(2):249–53.
Merli G, Spiro TE, Olsson CG, Abildgaard U, Davidson BL, Eldor A, Elias D, Grigg A, Musset D, Rodgers GM, Trowbridge AA, Yusen RD, Zawilska K. Subcutaneous enoxaparin once or twice daily compared with intravenous unfractionated heparin for treatment of venous thromboembolic disease. Ann Intern Med 2001;134(3):191–202.
Crockett AO, Wittwer CT. Fluorescein-labeled oligonucleotides for real-time pcr: using the inherent quenching of deoxyguanosine nucleotides. Anal Biochem 2001;290(1):89–97.
Borges CR, Roberts JC, Wilkins DG, Rollins DE. Relationship of melanin degradation products to actual melanin content: application to human hair. Anal Biochem 2001;290(1):116–25.
Willman JH, White K, Coffin CM. Pediatric core needle biopsy: strengths and limitations in evaluation of masses. Pediatr Dev Pathol 2001;4(1):46–52.
Mojica MP, Perry SS, Searles AE, Elenitoba-Johnson KS, Pierce LJ, Wiesmann A, Slayton WB, Spangrude GJ. Phenotypic distinction and functional characterization of pro-B cells in adult mouse bone marrow. J Immunol 2001;166(5):3042–51.
Lehman CM, Rodgers GM. To IRB or not to IRB? That is no longer the question. Am J Clin Pathol 2001;115(2):187–91.
Martins TB, Woolstenhulme RD, Jaskowski TD, Hill HR, Litwin CM. Comparison of four enzyme immunoassays with a western blot assay for the determination of type-specific antibodies to herpes simplex virus. Am J Clin Pathol 2001;115(2):272–7.
Perkins SL, Yang CH, Ashton PA, Jaffe GJ. Pharmacokinetics of the ganciclovir implant in the silicone-filled eye. Retina 2001;21(1):10–4.
Chandramouli NB, Rodgers GM. Management of thrombosis in women with antiphospholipid syndrome. Clin Obstet Gynecol 2001;44(1):36–47.
Florell SR, Coffin CM, Holden JA, Zimmermann JW, Gerwels JW, Summers BK, Jones DA, Leachman SA. Preservation of RNA for functional genomic studies: a multidisciplinary tumor bank protocol. Mod Pathol 2001;14(2):116–28.
Roberts WL, Moulton L, Law TC, Farrow G, Cooper-Anderson M, Savory J, Rifai N. Evaluation of nine automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Part 2. Clin Chem 2001;47(3):418–25.
Florell SR, Layfield LJ, Gerwels JW. A comparison of touch imprint cytology and Mohs frozen-section histology in the evaluation of Mohs micrographic surgical margins. J Am Acad Dermatol 2001;44(4):660–4.
Dunphy CH, Perkins SL. Large cell variants of CD5+, CD23- B-cell lymphoma/leukemia. Arch Pathol Lab Med 2001;125(4):513–8.
Gupta D, Holden J, Layfield L. Topoisomerase alpha II, retinoblastoma gene product, and p53: potential relationships with aggressive behavior and malignant transformation in recurrent respiratory papillomatosis. Appl Immunohistochem Mol Morphol 2001;9(1):86–91.
Busby LT, Weyman A, Rodgers GM. Excessive anticoagulation in patients with mild renal insufficiency receiving long-term therapeutic enoxaparin. Am J Hematol 2001;67(1):54–6.
Stern RC, Liu K, Dodge RK, Elenitoba-Johnson KS, Layfield LJ. Significance of lymphoglandular bodies in bone marrow aspiration smears. Diagn Cytopathol 2001;24(4):240–3.
Valencerina Gopez E, Dauterman J, Layfield LJ. Fine-needle aspiration biopsy of alveolar rhabdomyosarcoma of the parotid: a case report and review of the literature. Diagn Cytopathol 2001;24(4):249–52.
Goldstein NS, Bassi D, Watts JC, Layfield LJ, Yaziji H, Gown AM. E-cadherin reactivity of 95 noninvasive ductal and lobular lesions of the breast. Implications for the interpretation of problematic lesions. Am J Clin Pathol 2001;115(4):534–42.
Roberts WL, Annesley TM, De BK, Moulton L, Juenke JM, Moyer TP. Performance characteristics of four free phenytoin immunoassays. Ther Drug Monit 2001;23(2):148–54.
Marshall CJ, Thrasher AJ. The embryonic origins of human haematopoiesis. Br J Haematol 2001;112(4):838–50.
Kushnir MM, Urry FM. Use of a statistically designed experimental approach to optimize the propylketal derivatization of barbiturates. J Chromatogr Sci 2001;39(4):129–36.
Lyon E, Millson A, Lowery MC, Woods R, Wittwer CT. Quantification of HER2/neu gene amplification by competitive pcr using fluorescent melting curve analysis. Clin Chem 2001;47(5):844–51.
Annesley TM, Kurzyniec S, Nordblom GD, Buchanan N, Pool W, Reily M, Talaat R, Roberts WL. Glucuronidation of prodrug reactive site: isolation and characterization of oxymethylglucuronide metabolite of fosphenytoin. Clin Chem 2001;47(5):910–8.
Wehrli BM, Weiss SW, Yandow S, Coffin CM. Gardner-associated fibromas (GAF) in young patients: a distinct fibrous lesion that identifies unsuspected Gardner syndrome and risk for fibromatosis. Am J Surg Pathol 2001;25(5):645–51.
Wehrli BM, Weiss SW, Coffin CM. Gardner syndrome. Am J Surg Pathol 2001;25(5):694–6.
Jaskowski TD, Schroder C, Martins TB, Litwin CM, Hill HR. IgA antibodies against endomysium and transglutaminase: a comparison of methods. J Clin Lab Anal 2001;15(3):108–11.
Rohr LR, Layfield LJ, Wallin D, Hardy D. A comparison of routine and rapid microwave tissue processing in a surgical pathology laboratory. Quality of histologic sections and advantages of microwave processing. Am J Clin Pathol 2001;115(5):703–8.
Willman JH, Hill HR, Martins TB, Jaskowski TD, Ashwood ER, Litwin CM. Multiplex analysis of heterophil antibodies in patients with indeterminate HIV immunoassay results. Am J Clin Pathol 2001;115(5):764–9.
Frank EL, Hughes MP, Bankson DD, Roberts WL. Effects of anticoagulants and contemporary blood collection containers on aluminum, copper, and zinc results. Clin Chem 2001;47(6):1109–12.
Erali M, Page S, Reimer LG, Hillyard DR. Human immunodeficiency virus type 1 drug resistance testing: a comparison of three sequence-based methods. J Clin Microbiol 2001;39(6):2157–65.
Dunphy CH, Perkins SL. Mantle cell leukemia, prolymphocytoid type: a rarely described form. Leuk Lymphoma 2001;41(5–6):683–7.
Coffin CM, Patel A, Perkins S, Elenitoba-Johnson KS, Perlman E, Griffin CA. ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol 2001;14(6):569–76.
Prasher JM, Elenitoba-Johnson KS, Kelley LL. Loss of p53 tumor suppressor function is required for in vivo progression of Friend erythroleukemia. Oncogene 2001;20(23):2946–55.
Lyon E, Frank EL. Hereditary hemochromatosis since discovery of the HFE gene. Clin Chem 2001;47(7):1147–56.
Lehman CM, Blaylock RC, Alexander DP, Rodgers GM. Discontinuation of the bleeding time test without detectable adverse clinical impact. Clin Chem 2001;47(7):1204–11.
Reading NS, Aust SD. Role of disulfide bonds in the stability of recombinant manganese peroxidase. Biochemistry 2001;40(27):8161–8.
Perkins SL, Keller AK. Phylogeny of nuclear small subunit rRNA genes of hemogregarines amplified with specific primers. J Parasitol 2001;87(4):870–6.
Hess JR, Hill HR, Oliver CK, Lippert LE, Greenwalt TJ. The effect of two additive solutions on the postthaw storage of RBCs. Transfusion 2001;41(7):923–7.
Layfield LJ, Cramer H, Madden J, Gopez EV, Liu K. Atypical squamous epithelium in cytologic specimens from the pancreas: cytological differential diagnosis and clinical implications. Diagn Cytopathol 2001;25(1):38–42.
Maguire PD, Samulski TV, Prosnitz LR, Jones EL, Rosner GL, Powers B, Layfield LW, Brizel DM, Scully SP, Harrelson JM, Dewhirst MW. A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy. Int J Hyperthermia 2001;17(4):283–90.
Gardner LJ, Polski JM, Evans HL, Perkins SL, Dunphy CH. CD30 expression in follicular lymphoma. Arch Pathol Lab Med 2001;125(8):1036–41.
Fausett MB, Vogtlander M, Lee RM, Esplin MS, Branch DW, Rodgers GM, Silver RM. Heparin-induced thrombocytopenia is rare in pregnancy. Am J Obstet Gynecol 2001;185(1):148–52.
Elenitoba-Johnson KS. Complex regulation of telomerase activity: implications for cancer therapy. Am J Pathol 2001;159(2):405–10.
Hindiyeh M, Hillyard DR, Carroll KC. Evaluation of the Prodesse Hexaplex multiplex PCR assay for direct detection of seven respiratory viruses in clinical specimens. Am J Clin Pathol 2001;116(2):218–24.
Hess JR, Rugg N, Knapp AD, Gormas JF, Hill HR, Oliver CK, Lippert LE, Greenwalt TJ. The role of electrolytes and pH in RBC ASs. Transfusion 2001;41(8):1045–51.
Mirrett S, Weinstein MP, Reimer LG, Wilson ML, Reller LB. Relevance of the number of positive bottles in determining clinical significance of coagulase-negative staphylococci in blood cultures. J Clin Microbiol 2001;39(9):3279–81.
Rodgers GM. Identity of the tissue factor-inducing activity in human plasma. Br J Haematol 2001;114(2):485.
Elenitoba-Johnson KS, Bohling SD. Solution-based scanning for single-base alterations using a double-stranded DNA binding dye and fluorescence-melting profiles. Am J Pathol 2001;159(3):845–53.
Freye HB, King J, Litwin CM. Variations of pollen and mold concentrations in 1998 during the strong El Nino event of 1997-1998 and their impact on clinical exacerbations of allergic rhinitis, asthma, and sinusitis. Allergy Asthma Proc 2001;22(4):239–47.
Gupta D, Shidham V, Holden J, Layfield L. Value of topoisomerase II alpha, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu immunohistochemical expression for the prediction of biologic behavior in adrenocortical neoplasms. Appl Immunohistochem Mol Morphol 2001;9(3):215–21.
Paulsen RB, Wilkins DG, Slawson MH, Shaw K, Rollins DE. Effect of four laboratory decontamination procedures on the quantitative determination of cocaine and metabolites in hair by HPLC-MS. J Anal Toxicol 2001;25(7):490–6.
Layfield LJ, Bentz JS, Gopez EV. Immediate on-site interpretation of fine-needle aspiration smears: a cost and compensation analysis. Cancer 2001;93(5):319–22.
von Ahsen N, Wittwer CT, Schutz E. Oligonucleotide melting temperatures under PCR conditions: nearest-neighbor corrections for Mg(2+), deoxynucleotide triphosphate, and dimethyl sulfoxide concentrations with comparison to alternative empirical formulas. Clin Chem 2001;47(11):1956–61.
Kushnir MM, Komaromy-Hiller G, Shushan B, Urry FM, Roberts WL. Analysis of dicarboxylic acids by tandem mass spectrometry. High-throughput quantitative measurement of methylmalonic acid in serum, plasma, and urine. Clin Chem 2001;47(11):1993–2002.
Cook JR, Dehner LP, Collins MH, Ma Z, Morris SW, Coffin CM, Hill DA. Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. Am J Surg Pathol 2001;25(11):1364–71.
Argani P, Fritsch MK, Shuster AE, Perlman EJ, Coffin CM. Reduced sensitivity of paraffin-based RT-PCR assays for ETV6-NTRK3 fusion transcripts in morphologically defined infantile fibrosarcoma. Am J Surg Pathol 2001;25(11):1461–4.
Cessna MH, Zhou H, Perkins SL, Tripp SR, Layfield L, Daines C, Coffin CM. Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics. Am J Surg Pathol 2001;25(9):1150–7.
Hill HR, Oliver CK, Lippert LE, Greenwalt TJ, Hess JR. The effects of polyvinyl chloride and polyolefin blood bags on red blood cells stored in a new additive solution. Vox Sang 2001;81(3):161–6.
Vaughn CP, Elenitoba-Johnson KS. Intrinsic deoxyguanosine quenching of fluorescein-labeled hybridization probes: a simple method for real-time PCR detection and genotyping. Lab Invest 2001;81(11):1575–7.
Emerson L, Layfield LJ, Reiss R, Mulvihill S, Holden J. Malignant islet cell tumor with sarcomatous differentiation. Mod Pathol 2001;14(11):1187–91.
Coleman ML, Marshall CJ. A family outing: small GTPases cyclin' through G1. Nat Cell Biol 2001;3(11):E250–1.
Roberts WL, Schwarz EL, Ayanian S, Rifai N. Performance characteristics of a point of care C-reactive protein assay. Clin Chim Acta 2001;314(1–2):255–9.
Lei B, DeLeo FR, Hoe NP, Graham MR, Mackie SM, Cole RL, Liu M, Hill HR, Low DE, Federle MJ, Scott JR, Musser JM. Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis. Nat Med 2001;7(12):1298–305.
Chen Z, Coffin CM, Smith LM, Issa B, Arndt S, Shepard R, Brothman L, Stratton J, Brothman AR, Zhou H. Cytogenetic-clinicopathologic correlations in rhabdomyosarcoma: a report of five cases. Cancer Genet Cytogenet 2001;131(1):31–6.
Litwin CM, Quackenbush J. Characterization of a Vibrio vulnificus LysR homologue, HupR, which regulates expression of the haem uptake outer membrane protein, HupA. Microb Pathog 2001;31(6):295–307.
Robetorye RS, Rodgers GM. Update on selected inherited venous thrombotic disorders. Am J Hematol 2001;68(4):256–68.
Wittwer CT, Herrmann MG, Gundry CN, Elenitoba-Johnson KS. Real-time multiplex PCR assays. Methods 2001;25(4):430–42.
Lyon E. Mutation detection using fluorescent hybridization probes and melting curve analysis. Expert Rev Mol Diagn 2001;1(1):92–101.
Kim JE, Perkins SL, Schwiesow T, Connor TBJr, Han DP. Transpupillary thermotherapy of occult choroidal neovascularization in age-related macular degeneration. Semin Ophthalmol 2001;16(2):86–9.