Pediatric Reference Range Study

ARUP Pediatric Reference Intervals

ARUP is committed to establishing pediatric reference intervals. Jointly sponsored by ARUP Laboratories and the University of Utah Department of Pathology, the Children’s Health Improvement through Laboratory Diagnostics (CHILDx®) program was formed in 1999 and included a National Advisory Committee.

CHILDx focused on the unique challenges of pediatric laboratory medicine. Working in partnership with pediatric healthcare professionals across the country, the program aspired to improve the healthcare of children through service, education, and research in pediatric laboratory testing.

To validate a method for use in the diagnosis of clinical disorders, the hormones or chemical substances must be measured in large normal populations of various ages and both genders. In 2002, the pediatric reference interval study was initiated at ARUP for the purpose of determining pediatric reference intervals for a number of clinical laboratory assays. Demographic and health histories were obtained on each subject, with specimens collected at ARUP and Primary Children’s Medical Center in Salt Lake City, Utah.

Children 6 months through 6 years:
  • Fasting serum collected
  • Collection goal: 240 males and 240 females from each year of life (85 percent complete)
  • 35 reference intervals established toward the 66 proposed
Children 7 years through 17 years:
  • Full physical exam
  • Tanner staging
  • Serum, citrated plasma, and urine collected
  • Goal: 120 males and 120 females from each year of life (completed)
  • 58 reference intervals established toward the 144 proposed
  • Specimen collection expanded to include: 40 fasting specimens from males and females for each year of life (30 percent completed)

92 percent of the collection goal has been completed. Several relevant publications are related to these collections. ARUP continues to test different analytes as clinical utility dictates. References ranges are established for many of our tests and can be found on our Laboratory Test Directory (LTD) by specific test.