Fluorescent In Situ Hybridization (FISH)

Fluorescent in situ hybridization (FISH) is a sensitive and accurate technique that allows the detection of chromosome aberrations. In this method, a single-stranded fluorescent-labeled nucleic acid sequence (probe) complementary to a target genomic sequence is hybridized to detect the presence or absence of a given abnormality. FISH is a method of choice for diagnosis, prognosis, and treatment response in hematopoietic neoplasms (leukemia, lymphomas, multiple myeloma, and myelodysplasia) and solid tumors (breast cancer, non-small cell lung cancer, colorectal cancer, and cervical cancer).Testing of oncology specimens, whether the sample is blood, bone marrow, fresh tissue, or paraffin block, is available.

Test # Test Name Test Keywords Additional Information
2008604 1p/19q Deletion by FISH 1p19q, Oncology, Paraffin, Brain Tumors, Tumor Additional Technical Information
2002647 Acute Lymphocytic Leukemia (ALL) Panel by FISH, Adult FISH A ALL, B-Cell Lymphoma, MYC BCR-ABL1, MLL, IGH@, TCF3, E2A
2002719 Acute Lymphocytic Leukemia (ALL) Panel by FISH, Pediatric FISH P ALL, Oncology, Bone Marrow , B-Cell Lymphoma, childhood, child, children, CEP4, CEP10, BCR-ABL1 MLL, ETV6-RUNX1, TEL-AML1
2002653 Acute Myelogenous Leukemia (AML) with Myelodysplastic Syndrome (MDS), or Therapy-Related AML, by FISH F TAML MDS, Myelodysplastic syndrome, Acute Myeloid Leukemia, EGR1, D7S486, MLL
2011132 Acute Myelogenous Leukemia Panel by FISH FISH AML P, Acute Myeloid Leukemia, AML, Myeloproliferative, MPD, PML-RARA, RUNX1T1-RUNX1, ETO-AML1, CBFB, MLL, RPN1/MECOM, EVI1, EGR1, D7S486, KMT2A
2012710 Aggressive B-Cell Lymphoma FISH Reflex, Tissue
2011431 ALK (D5F3) by Immunohistochemistry with Reflex to ALK Gene Rearrangements by FISH
2006102 ALK Gene Rearrangements in NSCLC for Crizotinib Eligibility by FISH ALK GENE, Lung cancer, pharmcogenetics, pulmonary cancer
2010107 BCL6 (3q27) Gene Rearrangement by FISH Additional Technical Information
2002295 Chromosome FISH, CLL Panel FISH CLLP, Chronic Lymphocytic Leukemia, CLL, Lymphoma Phenotyping, B-Cell Lymphomas, Tumor Markers, ATM, D12Z3, D13S319, TP53, p53
2002298 Chromosome FISH, Interphase Oncology, Bone Marrow, Ewing Sarcoma, Neuroblastoma, Myelodysplastic, MDS, Chronic Lymphocytic Leukemia (CLL), Sarcoma, Acute Lymphoblastic Leukemia (ALL), Chronic Myelogenous Leukemia (CML), Tumor Markers, Acute Myeloid Leukemia (AML), Myeloproliferative Neoplasms (MPN), Plasma Cell Dyscrasias, Lymphoma Phenotyping, B-Cell Lymphomas Please specify which FISH probe you wish to order.
2006270 Chromosome FISH, Multiple Myeloma Panel Process and Hold MMF PR &HLD
2007223 DDIT3 (CHOP) (12q13) Gene Rearrangement by FISH CHOPFISH, Sarcoma, myxoid liposarcoma, round cell liposarcoma Additional Technical Information
2008605 EGFR by FISH EGFRFISH, Head and Neck Cancer, Lung Cancer, Brain Tumors Additional Technical Information
2002378 Eosinophilia Panel by FISH FISH EOS P, Mast Cell Disease, Eosinophilic Diseases, Acute Myeloid Leukemia (AML), Myeloproliferative Neoplasms (MPN), PDGFRA-CHIC2-FIP1L1, PDGFRB, FGFR1, CBFB
2002902 Epstein-Barr Virus (EBV) by in situ Hybridization, Paraffin Epstein-Barr Virus (EBV), Nasopharyngeal carcinoma, NK/ T-cell lymphomas, B-cell lymphomas, Post transplant lymphoproliferative disorders, Tumor Markers, ISH, Nasopharyngeal nonkeratinizing undifferentiated carcinoma, Nasal type NK/T-cell lymphoma
2008603 ERBB2 (HER-2/neu) Gene Amplification by FISH, Tissue HER2FISH, Breast Cancer, Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu, pathvision, pathvysion
2007225 EWSR1 (22q12) Gene Rearrangement by FISH EWSR1, Ewing Sarcoma, Sarcoma, Tumor Markers Additional Technical Information
2001497 FOXO1 (FKHR) (13q14) Gene Rearrangement by FISH FKHRFISH, Sarcoma, FOX, FOXO1, 13q14, alveolar rhabdomyosarcoma Additional Technical Information
2002899 Human Papillomavirus (HPV) High Risk In Situ Hybridization, Paraffin Gynecologic Cancer, ISH
2002896 Human Papillomavirus (HPV) Low Risk by In Situ Hybridization, Paraffin Gynecologic Cancer, ISH
2001536 IGH-BCL2 Fusion, t(14;18) by FISH for Detection in Follicular Lymphoma B-Cell Lymphomas, Follicular lymphoma, Diffuse large B-cell lymphoma, FISH Additional Technical Information
2007226 IGH-CCND1 Fusion, t(11;14) by FISH Mantle cell lymphoma, B-Cell Lymphomas, Plasma cell dyscrasias, Tumor Markers Additional Technical Information
2001538 IGH-MYC Fusion t(8;14) by FISH for Detection in Burkitt Lymphoma Burkitt lymphoma, B-Cell Lymphomas Additional Technical Information
2002888 Kappa/Lambda Light Chain Panel by in situ Hybridization, Paraffin Plasma cell dyscrasias, B-cell lymphomas, ISH More ISH testing
2008894 Lung Cancer Panel Panel consist of EFGR, ALK, ROS1, if ROS1 equivocal reflex to ROS1 FISH
Additional Technical Information
2008895 Lung Cancer Panel with KRAS Panel consist of EFGR, KRAS, ALK, ROS1, if ROS1 equivocal reflex to ROS1 FISH
Additional Technical Information
2002650 Lymphoma (Aggressive) Panel by FISH FISH ALYMP, Lymphoma Phenotyping, B-Cell Lymphomas, Lymphoproliferative Disorders (LPD), BCL6, MYC, IGH@/BCL2 Additional Technical Information
2003016 MDM2 Gene Amplification by FISH MDM2 FISH, Sarcoma, Tumor Markers, MDM2, Murine Double Minute 2 Additional Technical Information
2013082 MET Gene Amplification by FISH
2002294 Multiple Myeloma Panel by FISH FISH MMP, Plasma Cell Dyscrasias, CKS1B, ASS1, CCND1-IGH@, IGH@, PML, TP53, FGFR3-IGH@, IGH@-MAF
2002345 MYC (8q24) Gene Rearrangement by FISH Burkitt lymphomas, B-Cell Lymphomas, Double Hit lymphomas, Tumor Markers Additional Technical Information
2007227 MYCN (N-MYC) Gene Amplification by FISH NMYC, Neuroblastoma, Tumor Markers Additional Technical Information
2002709 Myelodysplastic Syndrome (MDS) Panel by FISH FISH MDS P, Myelodysplastic Syndrome (MDS), EGR1, D7S486, CEP8, D20S108
2002360 Myeloproliferative Disorders Panel by FISH FISH MPD P, Chronic Myelogenous Leukemia (CML), Myeloproliferative Neoplasms (MPN), PDGFRα-CHIC2-FIP1L1, PDGFRa-CHIC2-FIP1L1, PDGFRβ, FGFR1, ABL1-BCR
2002528 Pancreatobiliary FISH PF, Pancreatic Cancer, Tumor Markers
2002363 PML/RARα Translocation by FISH FISH PML, Acute Myeloid Leukemia (AML), Acute Promyelocytic Leukemia (APL), Tumor Markers
2012654 RET Gene Rearrangements by FISH
2008418 ROS1 by FISH Additional Technical Information
2008414 ROS1 with Interpretation by Immunohistochemistry with Reflex to FISH if Equivocal or Positive Additional Technical Information
2007222 SS18 (SYT) (18q11) Gene Rearrangement by FISH Additional Technical Information
2001181 UroVysion FISH UF, Bladder Cancer, Tumor Markers, urine