ARUP Genetic Counseling—Guideline Alerts

NCCN Guidelines (most recent guidelines available at www.NCCN.org)

  • The latest version (1.2019) of the NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast and Ovarian was released on July 11, 2018. Updates to the BRCA1 and BRCA2 testing criteria include individuals with a personal history of pancreatic cancer or metastatic prostate cancer without additional family history. In addition, individuals with a BRCA-related cancer may benefit from genetic testing as related to targeted treatment. NCCN Guidelines can be found at www.NCCN.org.

  • The latest version (1.2018) of the NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal was released on July 12, 2018. Updates to the Lynch syndrome criteria include consideration of a lower threshold on the PREMM5 predictive model (>2.5%) in conjunction with clinical judgement. In addition, Lynch syndrome evaluation may be considered in individual with a colorectal tumor diagnosed by age 60 with MSI-high histology, which includes presence of tumor-infiltrating lymphocytes, Crohn’s-like lymphocytic reaction, mucinous/signet ring differentiation, or medullary growth pattern. NCCN Guidelines can be found at www.NCCN.org.