ARUP Genetic Counseling—Guideline Alerts

A new version (1.2017) of the NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal was released on June 5, 2017. The update includes a revised format and three new actionable genes (AXIN2, NTHL1, and MSH3). Recommended management for these new genes includes beginning colonoscopy at age 25-30 years, and repeat every 2-3 years if negative. If polyps are found, repeat every 1-2 years with surgical consideration if unmanageable polyp burden. NCCN Guidelines can be found at