Echosens Fibrometer (Liver Fibrosis, Chronic Viral Hepatitis)

General Questions

Does it matter which instrument is used to generate the platelet count?

  • No. Many hematology analyzers are available and are suitable for the FibroMeter test. Please contact us at fibrometer@aruplab.com if you have questions regarding a specific analyzer.

Why is urea used in FibroMeter?

  • Each of the individual analytes in the algorithm have been shown to be a marker for liver function. This includes urea, which decreases with impaired liver function and advanced liver disease. However, the accuracy of using the FibroMeter test to assess fibrosis is based on a proprietary algorithm that evaluates and weighs the concentration of each analyte along with demographic data to provide a score.

Test Interpretation and Strategy

The result states that "FibroMeter and CirrhoMeter scores are modified by the rules-based algorithm." What does this mean?

  • To reduce misclassification, test scores are evaluated by a rule-based algorithm to detect anomalous profile results, which may modify test scores as needed.

Can this test be used if a patient has a co-infection of HCV/HIV or HBV/HIV?

  • Yes.

Performance and Limitations

Can this test be used on patients receiving ribavirin therapy?

  • Yes.

What is the clinical performance of this test?
Metavir
Classification
FibroMeter
≥F2 F4
AUROC 0.85–0.89 0.91
Sensitivity % 80.5–89.0 94.1
Specificity % 84.1–89.9 87.6
PPV % 82.0–86.3 68.0
NPV % 77.6–82.5 94.7
Can this test be run without the platelet count?

  • No. The platelet count is necessary for the score calculation. If necessary, platelet count values from an earlier or later draw can be used. However, the date of platelet count must be within three days from the collection of the other blood samples submitted to ARUP for the FibroMeter test.

Can this test be used on a pediatric patient?

  • The FibroMeter test was validated on patients age 18 or older. Pediatric specimens will not be rejected, but results should be interpreted with caution.