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Carl T. Wittwer, MD, PhD
Medical Director: Immunologic Flow Cytometry
Professor, University of Utah
- Rapid-cycle and extreme PCR
- High resolution DNA melting analysis
- Doctorate Degree—Biochemistry, Utah State University
- Medical Degree—University of Michigan
- Residency—University of Utah School of Medicine
- American Board of Pathology
- Instrument prototyping
- Fluorescent analysis of DNA amplification and melting
- Reducing molecular testing turnaround time
- Utah Genius: Life Time Achievement Honoree, 2015
- Pioneers of Progress Award, Science and Technology Development, 2015
- Excellence in Innovation and Commercialization, University of Utah, 2017
- Lifetime Achievement in Resident Education, University of Utah, 2019
- Cotlove Award, Academy of Clinical Laboratory Physicians and Scientists (ACLPS), 2019
- Millington AL, et al. The kinetic requirements of extreme qPCR. Biomol Detect Quantif. 2019 Mar 13;17:100081.
- Myrick JT, et al. Integrated extreme real-time PCR and high-speed melting analysis in 52-87 seconds. Clin Chem. 2019 Feb;65(2):263–71.
- Andini N, et al. A “culture shift”: broad bacterial detection, identification, and antimicrobial susceptibility testing directly from whole blood. Clin Chem. 2018 Oct;64(10):1453–62.
- Rejali NA, Moric E, Wittwer CT. The effect of single mismatches on primer extension. Clin Chem. 2018 May;64(5):801–9.
- Li M, et al. Quantifying variant differences in DNA melting curves: effects of length, melting rate, and curve overlay. Anal Biochem. 2017 Dec 15;539:90–5.
- Pryor R, et al. High-speed melting analysis: the effect of melting rate on microfluidic genotyping. Clin Chem. 2017 Oct;63(10):1624–32.
- Tashi T, et al. Gain-of-function ELGN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders. J Mol Med. 2017 Jun;95(6):665–70.
- Geiersbach KB, et al. Genomic copy number analysis of HER2-equivocal breast cancers. Am J Clin Path. 2016 Oct;146(4):439–47.
- Rifai N, et al. Disruptive innovation in laboratory medicine. Clin Chem. 2015 Sep;61(9):1129–32.
- Liew M, et al. Detection of chromosomal translocations in formalin-fixed paraffin embedded (FFPE) leukemic specimens by digital expression profiling. Int J Lab Hematol. 2015 Oct;37(5): 690–8.
- Zhou L, et al. Copy number assessment by competitive PCR with limiting dNTPs and high resolution melting. Clin Chem. 2015 May;61(5):724–33.
- Liew M, et al. Rare event counting of CD59- red cells in normal human blood: a 47 month experience using PNH consensus guidelines for WBC and RBC testing in a reference lab. Cytometry B Clin Cytom. 2015 Jul-Aug;88(4):261–9.
- Farrar JS, Wittwer CT. Extreme PCR: efficient and specific DNA amplification in 15–60 seconds. Clin Chem. 2015 Jan;6(1):145–53.
- Chiu RW, Lo YM, Wittwer CT. Molecular diagnostics: a revolution in progress. Clin Chem. 2015 Jan;61(1):1–3.
- Sundberg SO, et al. Microfluidic genotyping by rapid serial PCR and high-speed melting analysis. Clin Chem. 2014 Oct;60(10):1306–13.
- Sundberg S, Wittwer CT, Gale, BK. (2014). Quasi-digital PCR: enrichment and quantification of rare DNA variants. Biomedical Microdevices. 2014 Aug;16(4):639–44.
- Li M, et al. Genotyping accuracy of high-resolution DNA melting instruments. Clin Chem. 2014 Jun;60(6):864–72.
- Montgomery JL, Rejali N, Wittwer CT. The influence of nucleotide sequence and temperature on the activity of thermostable DNA polymerases. J Mol. Diag. 2014 May;16(3):305–13.
- Dwight ZL, et al. Heterozygote PCR product melting curve prediction. Hum Mutat. 2014 Mar;35(3):278–82.
- Sanford LN, Wittwer CT. Fluorescence-based temperature control for polymerase chain reaction. Anal Biochem. 2014 Mar 1;448:75–81.