AACC Annual Meeting & Clinical Lab Expo

July 29–August 2, 2018
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Medical and Economic Benefits of Monitoring Plasma Imatinib Concentrations

Tuesday, July 31, 10 a.m., booth #2448

Guiding imatinib therapy by monitoring plasma drug concentrations can improve the likelihood of response. Monitoring is useful when imatinib therapy is initiated, a change is made to a patient’s drug therapy, variable pharmacokinetics are suspected, or therapeutic failure is evaluated. This presentation will show how assuring adherence and evaluating dosage can minimize therapy costs and may prevent medical expenses associated with disease progression or relapse.

With imatinib the only TKI (tyrosine kinase) inhibitor available generically, there’s a real economic benefit if patients can be optimized on this drug.

Gwendolyn McMillin, PhD, is a professor of pathology at the University of Utah School of Medicine. She received her PhD in pharmacology and toxicology from the University of Utah, is ABCC board-certified in clinical and toxicological chemistry, and is actively involved in associations such as IATDMCT, AACC, and CAP.

Hepatitis B: Update in Guidelines for Laboratory Testing and Patient Management

Tuesday, July 31, 2 p.m., booth #2448

While screening, vaccination, and prevention measures have significantly reduced the incidence of hepatitis B (HBV) infection, it is estimated that as many as 2.2 million individuals are living with chronic HBV infection in the U.S. Reducing morbidity and mortality due to chronic HBV infection and associated complications, including liver failure and hepatocellular carcinoma, remains a priority. Updated 2018 guidelines address screening and prevention, use of specialized virologic and serologic tests, and treatment in a variety of special populations—including individuals with acute HBV infection and recipients of immunosuppressive therapy. This presentation will focus on diagnostic challenges and new tools in laboratory testing and HBV patient management.

This update in guidelines reinforces the continued need for improved diagnostic tools and therapy options.

Patricia Slev, PhD, is the section chief of Immunology at ARUP and an associate professor of pathology at the University of Utah School of Medicine. She earned her PhD in immunology and laboratory medicine from the University of Florida, Gainesville and completed a fellowship in clinical chemistry at the University of Utah.

Creating a Reference Lab Formulary: Where to Start

Wednesday, August 1, 10 a.m., booth #2448

Reference laboratory tests used appropriately provide information critical to the delivery of quality healthcare to patients. As test menus expand and reference-test costs increase, health systems are searching for ways to ensure this appropriate use for highquality, cost-efficient care. This presentation explores how to develop a physician-centric reference laboratory formulary as one strategy to maintain quality while also achieving direct and downstream cost efficiencies.

In creating a laboratory formulary, the process is more important than the list of tests itself. Each hospital’s formulary should be unique based on patient populations and medical staff.

Andrew Fletcher, MD, CPE, is a board-certified anatomic/clinical pathologist and certified physician executive with significant experience in reducing clinical variation to effectively promote safety and value. He earned his MD from Mercer University School of Medicine in Georgia and is pursuing an MBA from the University of Massachusetts at Amherst.

Lab at the Center of Care Delivery in 2020 (The Future)

Wednesday, August 1, 2 p.m., booth #2448

In an era of financial pressure and declining reimbursements, with hospitals striving to improve patient care, quality, access, and outcomes while increasing outpatient service delivery, balance is a struggle. This discussion will explore the true value and contributions an effective, efficient laboratory and outreach program can have at the center of a financially stable health system in 2020. Together, we will examine the danger of not routinely collaborating with those in strategic planning and operational positions within our health systems.

If you’re not continually discussing the systemwide, downstream clinical and financial ROI of your laboratory— who is? Are others telling the same story, sharing the same financial value model?

Jerri Turner-Jacyno is vice president of strategic relationships at ARUP, where she has worked for more than 25 years. Her 30-plus years of experience in healthcare includes work as a senior account representative, business development manager, and regional VP of sales. She earned her bachelor’s in business management and marketing from University of Central Florida.


Kushnir MM, Straseski JA—Poster
Kushnir MM, Straseski JA. A novel method for free 25 hydroxy (25OHD) vitamin D measurement by LC-MS/MS: free 25OHD associated with PTH and calcium better than total 25OHD.

La'ulu SL, Genzen JR—Poster
La'ulu SL, Warner K, Fisher KC, Genzen JR. Comparison of results from paired specimens collected in BD Vacutainer barricor plasma collection tubes and BD Vacutainer PST tubes.

Lu J, Genzen JR—Poster
Lu J, Genzen JR, Grenache DG. Development of an enzymatic assay to measure lactate in perchloric acid-precipitated cerebrospinal fluid.

Hunsaker JJH, Wyness SP, Genzen JR—Poster
Hunsaker JJH, Wyness SP, Genzen JR. Evaluation of L-Index interference limits on Roche cobas c502 and c702 Immunoturbidimetric assays using endogenously lipemic specimens.

Kushnir MM, La'ulu SL, Straseski JA—Poster
Kushnir MM, La'ulu SL, Straseski JA. Free 25 hydroxy vitamin D by LC-MS/MS: reference intervals in healthy adults and observations in pre-/post-menopausal women.

Erickson JA—Poster
Erickson JA, Jung TI, Choi MA, Grenache DG. Lipoprotein particle stability in serum for nuclear magnetic resonance analysis.

Taylor L, Johnson-Davis KL—Poster
Maharjan AS, Taylor L, Johnson-Davis KL. Multiple drug classes and metabolites: qualitative analysis in serum/plasma by LC-MS/MS.

Lozier B, Yuzyuk T, Pasquali M, De Biase I—Poster
Lozier B, Yuzyuk T, Chong J, Pasquali M, De Biase I. Quantitative analysis of organic acids in plasma using acidified methanol extraction and detection by gas chromatography-mass spectrometry.

McMillin GA—Poster
Smy L, McMillin GA. Urine buprenorphine and metabolite patterns in a large cohort of patients.

Melis R, Donahue WL, McMillin GA—Poster
Gherasim C, Melis R, Donahue WL, McMillin GA. Genotyping of selected alleles involved in tramadol metabolism provide evidence for additional factors beyond CYP2D6-inffered phonotype that may contribute to observed metabolite patterns.


Monday, July 30

Going Beyond LDL Cholesterol: Clinical Indications and Methodologies for Advanced Lipid Testing.
Valentinas Gruzdys, PhD
7:30–8:30 a.m. & 12:30–1:30 p.m. | brown bag
Session a.m. #42113; p.m. #52213
Viral Hepatitis: Advances and Current Challenges
Patricia Slev, PhD
7:30–8:30 a.m. & 12:30–1:30 p.m. | brown bag
Session a.m. #42131; p.m. #52231
Update on Thyroid Disease in Pregnancy
Joely Straseski, PhD
10:30 a.m.–12:00 p.m. | scientific session
Session #32102

Tuesday, July 31

Heterophile Antibodies: An Interference You Can’t Afford to Miss
Anu Maharjan, PhD
7:30–8:30 a.m. & 12:30–1:30 p.m. | brown bag
Session a.m. #43123; p.m. #53223
Gaps in Knowledge and Controversies Surrounding Thyroglobulin Measurement and Interpretation
Joely Straseski, PhD
10:30 a.m.–12:00 p.m. | scientific session
Session #33103
Emerging Strategies for Value-based Laboratory Stewardship Aimed at Improving Outcomes and Reducing Diagnostic Errors
Robert Schmidt, MD, PhD, MBA
10:30 a.m.–12:00 p.m. | scientific session
Session #33104
Leadership Strategies: Cultivating Engagement Through Leadership
Cherie Petersen, BA
2:30–5:00 p.m. | scientific session
Session # 33213
Solving Laboratory Diagnostic Challenges with Technology, Automation, and Innovation - Closing the “Brain-to-Brain” Loop
Jonathan Genzen, MD, PhD
2:30–5:00 p.m. | scientific session
Session #33214
The Good, the Bad, and the Ugly: Opportunities and Challenges for Harmonization of Autoantibody Testing
Anne Tebo, PhD
2:30–5:00 p.m. | scientific session
Session #33220

Wednesday, August 1

Therapeutic Drug Monitoring: Immunoassays vs LC-MS/MS
Kamisha Johnson-Davis, PhD
7:30–8:30 a.m. & 12:30–1:30 p.m. | brown bag
Session a.m. #44131; p.m. #54231

Thursday, August 2

Jumping the Pediatric Reference Interval Hurdles
Joely Straseski, PhD
10:30 a.m.–12:00 p.m. | scientific session
Session #35109
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