Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2003589 CD56 (NCAM) by Immunohistochemistry Brain Tumors, Sarcoma , Rhabdomyosarcomas, T/NK-Cell Lymphomas, Plasma Cell Dyscrasias, Tumor Markers, Lung Cancer Neural cell adhesion molecule (NCAM):
  • Expressed on natural killer cells and most neuroectodermal tissues
  • Retinoblastoma, medulloblastoma, astrocytoma, neuroblastoma, and rhabdomyosarcoma
2003592 CD57 by Immunohistochemistry T/NK-Cell Lymphomas, Tumor Markers Leu-7, HNK1:
  • Expressed by a subset of natural killer cells and some T-lymphocytes
  • Reacts with myelin-associated glycoprotein in neuroectodermal tissue
  • Aids in identifying small cell lung carcinoma, NK lymphocyte-mediated cytotoxicity, AIDS and AIDS-related complex (ARC), NK and T-cell subset tumors and neural tissue neoplasms
2003830 Chromogranin A by Immunohistochemistry Neuroendocrine Tumors (NET), Carcinoid Tumors, Medullary Thyroid Cancer, Tumor Markers, Paraganglioma, Carotid body tumor, Olfactory neuroblastoma, pituitary adenomas, islet cell tumors, phaeochromocytomas, medullary thyroid carcinomas, Merkel cell tumors, and carcinoids
  • Expressed in neuronal cells and in secretory granules of endocrine cells: parathyroid gland, adrenal medulla, anterior pituitary gland, islet cells of the pancreas, and C-cells of the thyroid
  • Aids in identifying neuroendocrine tumors: pituitary adenomas, islet cell tumors, phaeochromocytomas, medullary thyroid carcinomas, Merkel cell tumors, and carcinoids
2013261 Comprehensive Nerve Biopsy Workup
2005857 IDH1R132H Mutation by Immunohistochemistry Glial tumors, astrocytomas , oligodendrogliomas, glioblastomas
  • Distinguishes primary from secondary Glioblastoma multiform (GBM)
  • IDH1 mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors
  • Allows the highly sensitive and specific discrimination of various tumors, such as astrocytoma from primary glioblastomas or diffuse astrocytoma grade II from pilocytic astrocytoma or ependymoma
2004052 Neuron Specific Enolase, Polyclonal (NSE P) by Immunohistochemistry Neuroendocrine Marker, neuronal or neuroendocrine cells and their tumors: neuroblastomas and retinoblastomas Neuron-specific enolase:
  • Expressed by neuronal or neuroendocrine cells and their tumors: neuroblastomas and retinoblastomas
  • May label non-neuronal tumors: meningiomas, medulloblastomas, astrocytomas, glioblastomas, oligoastrocytomas, oligodendrogliomas, pituitary adenomas, schwannomas, ependymomas, meningosarcomas, gliosarcomas, small cell lung cancer, melanomas, and germ cell tumors
2004091 Protein Gene Product (PGP) 9.5 by Immunohistochemistry Glucagonoma, Somatostatinoma, VIPoma, Ewing Sarcoma, Gastrinoma, Pancreatic Neuroendocrine Tumors (NET), Carcinoid Tumors, Pancreatic Cancer, Pheochromocytoma, Tumor Markers, neuronal neoplasis Protein gene product 9.5:
  • Expressed in neurons, neuroendocrine cells, and melanocytes
  • Present in neuronal neoplasias (carcinoid tumors)
2004139 Synaptophysin by Immunohistochemistry Neuroendocrine Marker, Glucagonoma, Somatostatinoma, VIPoma, Insulinoma, Ewing Sarcoma, Gastrinoma, Pancreatic Neuroendocrine Tumors (NET), Carcinoid Tumors, Brain Tumors, Pancreatic Cancer, Pheochromocytoma, Lung Cancer, Tumor Markers
  • Labels neuroendocrine cells and neurons in the brain, spinal cord, and retina
  • Present in neuroendocrine tumors and neuroendocrine tumors of epithelial type