Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
Consultation, Muscle/Nerve Pathology Special Study
2003589 CD56 (NCAM) by Immunohistochemistry Brain Tumors, Sarcoma , Rhabdomyosarcomas, T/NK-Cell Lymphomas, Plasma Cell Dyscrasias, Tumor Markers, Lung Cancer Neural cell adhesion molecule (NCAM):
  • Expressed on natural killer cells and most neuroectodermal tissues
  • Retinoblastoma, medulloblastoma, astrocytoma, neuroblastoma, and rhabdomyosarcoma
2013261 Comprehensive Nerve Biopsy Workup
2003899 Glial Fibrillary Acidic Protein (GFAP) by Immunohistochemistry Gastrointestinal Stromal Tumors (GIST), Brain Tumors Glial fibrillary acidic protein:
  • Expressed in astrocytes and some CNS ependymal cells
  • Identifies astrocytomas and ependymomas
  • Many neural tumors, such as neuroblastomas, schwannomas, and extra-CNS tumors, do not stain
2004049 Neurofilament by Immunohistochemistry Tumor Markers
  • Cytoskeletal element in nerve axons/dendrites
  • Reacts with neurons, neuronal processes, peripheral nerves, sympathetic ganglion cells, and adrenal medulla
  • Identifies neuroblastoma and gangliomas
2004046 Neuronal Nuclei (NeuN) by Immunohistochemistry
  • Aids in the definitive identification of neuronal elements in ganglion cell tumors or hamartomas, in which a distinction between atypical glial cells and neurons may be difficult.
  • May be used, similarly, for the study of neuronal loss in epilepsy, neurodegenerative diseases, or other conditions
2004094 Paired Helical Filament -Tau (PHF-Tau) by Immunohistochemistry
  • Tau is abnormally phosphorlated in Alzheimer´s disease
  • Main component in paired helical filaments (PHFs) and neurofibrillary tangles
2004091 Protein Gene Product (PGP) 9.5 by Immunohistochemistry Glucagonoma, Somatostatinoma, VIPoma, Ewing Sarcoma, Gastrinoma, Pancreatic Neuroendocrine Tumors (NET), Carcinoid Tumors, Pancreatic Cancer, Pheochromocytoma, Tumor Markers, neuronal neoplasis Protein gene product 9.5:
  • Expressed in neurons, neuroendocrine cells, and melanocytes
  • Present in neuronal neoplasias (carcinoid tumors)
2004127 S-100 Protein by Immunohistochemistry Melanoma, Tumor Markers
  • Brain protein composed of S-100a and S-100b
  • Expressed in neural crest (Schwann cells, melanocytes, glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, and dendritic cells
  • Present in 95% of melanomas (including desmoplastic and spindle cell tumors), 50% of malignant peripheral nerve sheath tumors, clear cell sarcomas, and occasional breast and undifferentiated carcinomas
2004169 Ubiquitin by Immunohistochemistry
  • Detects intracellular ubiquinated filamentous inclusions in the periphery of senile plaques and neurofibrillary tangles in Alzheimer disease and Lewy bodies in Parkinson disease