Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
Consultation, Muscle/Nerve Pathology Special Study
2003484 Caldesmon by Immunohistochemistry Gastrointestinal Stromal Tumors, GIST, endometrial, stromal, smooth muscle tumors, Tumor Markers
  • High molecular weight isoform is H-caldesmon
  • Calcium-, calmodulin-, tropomyosin-, and actin-binding protein
  • Regulates smooth muscle contraction
  • Aids in identifying angioleiomyomas, glomus tumors, GIST, some endometrial stromal tumors, and uterine smooth muscle tumors (benign or malignant)
  • Differentiates uterine smooth muscle (usually positive) and endometrial stromal differentiation (usually negative)
2013260 Comprehensive Muscle Biopsy Workup
2003863 Desmin by Immunohistochemistry Smooth Muscle, Reactive Mesothelial cells, leiomyosarcomas, myogenic sarcomas, rhabdomyosarcoma, PNET, neuroblastoma, GIST, gastrointestinal stromal tumor, Tumor Markers
  • Intermediate filament present in smooth and striated muscle
  • Expressed in reactive mesothelial cells, myoblasts, myofibroblasts (variable), endometrial stroma, and smooth muscle cells
  • Aids in idenitifying smooth muscle tumors (leiomyosarcomas), myogenic sarcomas, striated muscle tumors (rhabdomyosarcoma), PNET, neuroblastomas, and intra-abdominal desmoplastic small round cell tumors
2004011 Muscle-Specific Actin (MSA) by Immunohistochemistry Sarcoma, leiomyomas, leiomyosarcomas, rhabdomyosarcomas, some pleomorphic liposarcomas, glomus tumors, desmoid tumors
  • Present in skeletal, cardiac, smooth muscle, and myoepithelial cells
  • Identifies soft tissue tumors with muscle differentiation (leiomyomas, leiomyosarcomas, and rhabdomyosarcomas), some pleomorphic liposarcomas, the majority of glomus tumors, occasional desmoid tumors, and myofibroblasts in some lesions
2004031 Myoglobin by Immunohistochemistry Sarcoma, Tumor Markers, rhabdomyosarcomas
  • Oxygen binding protein
  • Expressed by striated muscle (cardiac, skeletal)
  • Present in rhabdomyosarcoma and other tumors with skeletal muscle differentiation
2004034 Myosin by Immunohistochemistry Sarcoma, Tumor Markers, rhabdomyosarcomas
  • Contractile protein
  • Expressed in smooth muscle (non-sarcomeric) and skeletal muscle (sarcomeric) forms
  • Aids in muscle differentiation
2004130 Smooth Muscle Actin (SMA) by Immunohistochemistry Smooth Muscle Marker
  • Reacts with the alpha-smooth muscle isoform
  • Present in smooth muscle cells of vessels, parenchymes, myoepithelial cells, pericytes, and some stromal cells in the intestine, testis, and ovary
  • Aids in differentiating leiomyosarcoma from rhabdomyosarcoma