Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2003935 Melanoma Antibody, HMB45 by Immunohistochemistry Melanoma, Tumor Markers, HMB45 Melanoma-specific antigen:
  • Expressed in junctional cells, blue nevus cells, and fetal and neonatal melanocytes
  • Reacts with the majority of melanomas and other tumors with melanoma/melanocytic differentiation, including melanotic schwannoma clear cell sarcoma
2003996 Melan A by Immunohistochemistry Melanoma, Tumor Markers
  • MART-1 antigen
  • Expressed in melanocytes, steroid-producing cells of the adrenal cortex, ovary, and testis
  • Identifies melanomas, adrenocortical tumors, Leydig tumors of the testis, and Sertoli-Leydig ovarian tumors
2011998 MITF by Immunohistochemistry
  • Used in the identification of melanotic lesions, such as malignant melanoma and melanotic neurofibroma
2004017 Myogenin (Myf4) by Immunohistochemistry Sarcoma, Tumor Markers, leiomyosarcomas, rhabdomyosarcomas
  • Expressed early in skeletal muscle differentiation.
  • Is a sensitive and specific marker for rhabdomyosarcoma.
  • Is more specific than desmin and muscle-specific actin and more sensitive than myoglobin.
2004127 S-100 Protein by Immunohistochemistry Melanoma, Tumor Markers
  • Brain protein composed of S-100a and S-100b
  • Expressed in neural crest (Schwann cells, melanocytes, glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, and dendritic cells
  • Present in 95% of melanomas (including desmoplastic and spindle cell tumors), 50% of malignant peripheral nerve sheath tumors, clear cell sarcomas, and occasional breast and undifferentiated carcinomas